Restless leg syndrome: a risk factor of higher prevalence of anxiety and depression in Parkinson’s disease patients

Rana, Abdul Qayyum; Mosabbir, Abdullah; Qureshi, Abdul Rehman; Abbas, Muhammad Waseem; Rana, M. A. A.

doi:10.1080/01616412.2016.1147682

Cited by 16 publications

(10 citation statements)

References 12 publications

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“…However, an association between pain and RLS in the PD patient population was not explored. 21 Further exploratory analysis by other studies dwell into the link between RLS and sleep disorders within PD without assessing pain. [22][23][24] An interesting investigation probed pain in PD within the context of depression and linked disability from pain with higher ratings on the Beck Depression inventory.…”

Section: Discussionmentioning

confidence: 99%

Cross-Sectional Design: Link Between Parkinson’s Pain and Restless Leg Syndrome

Paul

Qureshi

Jamal

et al. 2021

J Geriatr Psychiatry Neurol

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Objective: Prior research suggests that restless leg syndrome (RLS) is prevalent in Parkinson’s disease (PD) with insufficient evidence to support the relationship between RLS, PD, and pain. This study explored the relationship between pain in PD patients and its association with the prevalence and severity of RLS. Method: 127 PD patients were assessed for PD and RLS using the U.K. Brain bank Criteria and the Restless Leg Syndrome diagnostic criteria, respectively. These patients were also assessed for pain perception and interference using the Brief Pain Inventory. Results: The results demonstrated Parkinson’s disease patients who reported pain scored 23 more Restless Leg Syndrome prevalence points ( p < 0.05), and 8.5 counts higher for Restless Leg Syndrome severity ( p < 0.05) compared to the group of Parkinson’s disease patients denying pain. Discussion: The presence of pain in PD patients indicated a higher RLS prevalence and an increased RLS severity. This finding suggests patients suffering from pain interference may experience more severe RLS symptoms. This demonstrates an inextricable link and association between pain in PD patients and RLS. Further robust investigations are required to elucidate any potential causative links, which can inform more holistic treatment principles.

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Section: Discussionmentioning

confidence: 99%

Cross-Sectional Design: Link Between Parkinson’s Pain and Restless Leg Syndrome

Paul

Qureshi

Jamal

et al. 2021

J Geriatr Psychiatry Neurol

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“…3 Attention deficit hyperactivity disorder, mood disorders, and other sleep disturbances are frequently comorbid with these conditions. [19][20][21][22] Both RLS and PLMS are associated with iron deficiency. [46][47][48][49][50] Most studies show that iron supplementation has been shown to improve symptoms, with goal ferritin levels > 50 µg/L, though no randomized clinical trials have been completed in children.…”

Section: Discussionmentioning

confidence: 99%

“…3,11,18 Indeed, patients with RLS have significant comorbidities in the areas of attention deficit hyperactivity disorder (ADHD), mood disorders, migraine headaches, and other sleep disorders. [19][20][21][22] Periodic Limb Movements in Sleep Periodic leg movements are common in RLS. Periodic leg movements can occur during wakefulness or during sleep, known as periodic limb movements in sleep (PLMS).…”

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confidence: 99%

The Role of Iron in Pediatric Restless Legs Syndrome and Periodic Limb Movements in Sleep

Munzer

Felt

2017

Semin Neurol

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Restless legs syndrome (RLS) is a common and treatable neurologic condition in pediatric patients, with a prevalence as high as 2 to 3%. The diagnosis of RLS is made clinically based on an urge to move the legs accompanied by lower extremity discomfort that occurs during rest usually later in the day and is relieved by movement. Periodic limb movements in sleep (PLMS) can overlap with RLS, although PLMS also exists as a separate entity characterized by stereotyped movements of lower extremities in sleep. Both conditions may be highly debilitating and interfere with daily function notably in the areas of educational attainment and behavioral regulation. Iron deficiency has been implicated in the pathophysiology of both RLS and PLMS. Current evidence suggests that treatment of ferritin levels < 50 µg/L may be beneficial in improving pediatric RLS symptoms and comorbid conditions or daytime dysfunction associated with RLS. Areas for future research include (1) clarifying the ferritin or other iron status measure level which predicts iron treatment will provide symptom improvement in pediatric patients, and (2) randomized clinical trials using iron therapy to determine the degree and duration of treatment.

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“…There are a variety of risk factors for patients with Parkinson's disease to develop depression. They include anxiety (91), premorbid history of depression (92), family history of depression (93), cognitive impairment (94), longer duration of illness (95), motor disability and gait as well as balance impairments (96), younger age (97), sleep disorders and restless leg syndrome (98), and female sex (99).…”

Section: Parkinson's Diseasementioning

confidence: 99%

Depression Comorbid With Stroke, Traumatic Brain Injury, Parkinson’s Disease, and Multiple Sclerosis: Diagnosis and Treatment

Conroy

Brownlowe

McAllister

2020

FOC

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Restless leg syndrome: a risk factor of higher prevalence of anxiety and depression in Parkinson’s disease patients

Abstract: The presence of RLS in PD patients may increase the occurrence of both anxiety and depression, but the severity of the symptoms is not significant in the two groups of the PD patients.

Cited by 16 publications

References 12 publications

Cross-Sectional Design: Link Between Parkinson’s Pain and Restless Leg Syndrome

Cross-Sectional Design: Link Between Parkinson’s Pain and Restless Leg Syndrome

The Role of Iron in Pediatric Restless Legs Syndrome and Periodic Limb Movements in Sleep

Depression Comorbid With Stroke, Traumatic Brain Injury, Parkinson’s Disease, and Multiple Sclerosis: Diagnosis and Treatment

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