Resting-state functional MRI language network connectivity differences in patients with brain tumors: exploration of the cerebellum and contralesional hemisphere

Cho, Nicholas S; Peck, Kyung K.; Gene, Madeleine; Jenabi, Mehrnaz; Holodny, Andrei I.

doi:10.1007/s11682-021-00498-5

Cited by 14 publications

(25 citation statements)

References 49 publications

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“…The uncomplete full coverage of the resting-state acquisition prevented us to study also these connections that have been mainly related in recent studies to language dysfunctions in glioma patients. 54 , 62 , 63 …”

Section: Discussionmentioning

confidence: 99%

Widespread cortical functional disconnection in gliomas: an individual network mapping approach

Silvestri

Moretto

Facchini

et al. 2022

Brain Communications

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Assessment of impaired/preserved cortical regions in brain tumours is typically performed via intraoperative direct brain stimulation of eloquent areas or task-based functional MRI. One main limitation is that they overlook distal brain regions or networks that could be functionally impaired by the tumour. This study aims: 1) to investigate the impact of brain tumours on the cortical synchronization of brain networks measured with resting-state functional magnetic resonance imaging (resting-state networks) both near the lesion and remotely; 2) to test whether potential changes in resting state networks correlate with cognitive status. The sample included twenty-four glioma patients (mean age 58.1 ± 16.4y) with different pathological staging. We developed a new method for single subject localization of resting state networks abnormalities. First, we derived the spatial pattern of the main resting state networks by means of the group guided independent component analysis. This was informed by a high-resolution resting state networks template derived from an independent sample of healthy controls. Second, we developed a spatial similarity index to measure differences in network topography and strength between healthy controls and individual brain tumour patients. Next, we investigated the spatial relationship between altered networks and tumour location. Finally, multivariate analyses related cognitive scores across multiple cognitive domains (attention, language, memory, decision making) with patterns of multi-network abnormality. We found that brain gliomas cause broad alterations of resting state networks topography that occurred mainly in structurally normal regions outside the tumour and oedema region. Cortical regions near the tumour often showed normal synchronization. Finally, multi-network abnormalities predicted attention deficits. Overall, we present a novel method for the functional localization of resting state networks abnormalities in individual glioma patients. These abnormalities partially explain cognitive disabilities and shall be carefully navigated during surgery.

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Section: Discussionmentioning

confidence: 99%

Widespread cortical functional disconnection in gliomas: an individual network mapping approach

Silvestri

Moretto

Facchini

et al. 2022

Brain Communications

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show abstract

“…Concerning neuro-oncology, previous studies indicated that cerebellum undergoes structural and functional alterations, especially concerning language function, induced by supratentorial high-grade and low-grade gliomas, confirming the role of cerebellar system in lesion induced plasticity process (177,178).…”

Section: Discussionmentioning

confidence: 74%

Networking of the Human Cerebellum: From Anatomo-Functional Development to Neurosurgical Implications

et al. 2022

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In the past, the cerebellum was considered to be substantially involved in sensory-motor coordination. However, a growing number of neuroanatomical, neuroimaging, clinical and lesion studies have now provided converging evidence on the implication of the cerebellum in a variety of cognitive, affective, social, and behavioral processes as well. These findings suggest a complex anatomo-functional organization of the cerebellum, involving a dense network of cortical territories and reciprocal connections with many supra-tentorial association areas. The final architecture of cerebellar networks results from a complex, highly protracted, and continuous development from childhood to adulthood, leading to integration between short-distance connections and long-range extra-cerebellar circuits. In this review, we summarize the current evidence on the anatomo-functional organization of the cerebellar connectome. We will focus on the maturation process of afferent and efferent neuronal circuitry, and the involvement of these networks in different aspects of neurocognitive processing. The final section will be devoted to identifying possible implications of this knowledge in neurosurgical practice, especially in the case of posterior fossa tumor resection, and to discuss reliable strategies to improve the quality of approaches while reducing postsurgical morbidity.

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“…Even earlier, Ullman and colleagues has inferred the existence of a basal ganglia-thalamocortical loop, in which Broca’s area is a station of information acceptance and feedback ( Ullman, 2006 ). The cerebellum may contribute to the word generation, semantic processing and sentence processing via specific cerebellocortical circuits ( Argyropoulos, 2016 , Moberget et al, 2016 , Schwartze and Kotz, 2016 , Cho et al, 2022 , Geva et al, 2021 ).meta-analyses have demonstrated significant activation of the right posterior cerebellum during a set of language tasks ( Stoodley and Schmahmann, 2009 , E et al, 2014 ).…”

Section: Discussionmentioning

confidence: 99%

The longitudinal neural dynamics changes of whole brain connectome during natural recovery from poststroke aphasia

Fan

Huang

et al. 2022

NeuroImage: Clinical

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Resting-state functional MRI language network connectivity differences in patients with brain tumors: exploration of the cerebellum and contralesional hemisphere

Cited by 14 publications

References 49 publications

Widespread cortical functional disconnection in gliomas: an individual network mapping approach

Widespread cortical functional disconnection in gliomas: an individual network mapping approach

Networking of the Human Cerebellum: From Anatomo-Functional Development to Neurosurgical Implications

The longitudinal neural dynamics changes of whole brain connectome during natural recovery from poststroke aphasia

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