Resting-state functional magnetic resonance imaging in patients with leukoaraiosis-associated subcortical vascular cognitive impairment: a cross-sectional study

Chen, Yu; Wang, Chunxue; Liang, Huazheng; Chen, Hongyan; Bi, Yanchao; Sun, Haixin; Shi, Qingli; Deng, Yongmei; Li, Jia; Wang, Yongjun; Zhang, Yumei

doi:10.1080/01616412.2016.1177929

Cited by 14 publications

(9 citation statements)

References 30 publications

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“…Many studies have shown ( 58 – 61 ) that FC abnormalities in VCI subjects are closely related to CI ( Figure 1 ). DMN is the key brain region for post-stroke CI.…”

Section: Application Of Rs-fmri In the Vci Studymentioning

confidence: 99%

The Application of rs-fMRI in Vascular Cognitive Impairment

et al. 2020

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The incidence of vascular cognitive impairment (VCI) has been increasing for years and has become a major disabling factor in middle-aged and elderly populations. The pathogenesis of VCI is unclear, and there are no standard diagnostic criteria. Resting-state functional magnetic resonance imaging (rs-fMRI) can be used to detect spontaneous brain functional activity in a resting state, which facilitates in-depth investigation of the pathogenesis of VCI and provides an objective reference for early diagnosis, differential diagnosis, and prognostic evaluation. This article mainly reviews the principle and analysis of rs-fMRI data, as well as the progress of its application for VCI diagnosis.

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“…Many studies have shown ( 58 – 61 ) that FC abnormalities in VCI subjects are closely related to CI ( Figure 1 ). DMN is the key brain region for post-stroke CI.…”

Section: Application Of Rs-fmri In the Vci Studymentioning

confidence: 99%

The Application of rs-fMRI in Vascular Cognitive Impairment

et al. 2020

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“…Cognitive impairment, the most common clinical feature associated with ILA, manifests as deficits in thinking ability, memory, executive function, and attention ability (Sultzer et al, 1995 ; Li et al, 2017 ). Previous studies have suggested that normal elderly individuals with ILA are at high-risk of further cognitive decline, and the magnitude of the ILA is positively correlated with the severity of cognitive deficits (Ross et al, 2005 ; Te et al, 2015 ; Chen et al, 2016 ). However, the neurobiological pathway underlying cognitive impairment in ILA has not been well illuminated.…”

Section: Introductionmentioning

confidence: 99%

“…Diffusion tensor imaging studies on ILA have demonstrated white matter (WM) changes, especially in the fronto-subcortical circuits (Viana-Baptista et al, 2008 ; Yuan et al, 2017 ). Additionally, evidence from functional brain connectome studies on ILA has further shown the involvement of the dysfunction of several networks in ILA, including the default mode network, frontoparietal network, dorsal attention network, salience network and corticostriatal network (Chen et al, 2016 , 2019 ; Liu et al, 2019a , b ). These studies have suggested that “brain network dysfunction” may be the best explanatory model for illuminating the neurobiological pathway underlying cognitive impairment in ILA.…”

Section: Introductionmentioning

confidence: 99%

Functional Disorganization of Small-World Brain Networks in Patients With Ischemic Leukoaraiosis

Zhu

Lü

Xie

et al. 2020

Front. Aging Neurosci.

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Cognitive impairment is a key clinical feature of ischemic leukoaraiosis (ILA); however, the underlying neurobiological mechanism is still unclear. ILA has been associated with widespread gray and white matter (WM) damage mainly located in cortical-cortical and cortico-subcortical pathways. A total of 36 patients with ILA (Fazekas rating score ≥2) and 31 healthy controls (HCs) underwent comprehensive neuropsychological assessments (covering four cognitive domains, i.e., information processing speed, episodic memory, executive and visuospatial function) and resting-state functional MRI scans. Graph theory-based analyses were employed to explore the topological organization of the brain connectome in ILA patients, and we further sought to explore the associations of connectome-based metrics and neuropsychological performances. An efficient small-world architecture in the functional brain connectome was observed in the ILA and control groups. Moreover, compared with the HCs, the ILA patients showed increased path length and decreased network efficiency (i.e., global and local efficiency) in their functional brain networks. Further network-based statistic (NBS) analysis revealed a functional-disconnected network in ILA, which is comprised of functional connections linking different brain modules (i.e., default mode, frontoparietal, ventral attention and limbic systems) and connections within single modules (i.e., ventral attention and limbic systems). Intriguingly, the abnormal network metrics correlated with cognitive deficits in ILA patients. Therefore, our findings provide further evidence to support the concept that ILA pathologies could disrupt brain connections, impairing network functioning, and cognition via a "disconnection syndrome."

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“…The default-mode network (DMN) is closely related to selective extraction and classification of episodic memory and self-cognition, and it plays an important role in cognitive function [17]. Patients with LA-associated subcortical vascular cognitive impairment (SVCI) exhibited significant differences in the functional alterations of the DMN, which might be a feature distinguishing between SVCI and amnestic mild cognitive impairment (aMCI) patients [18]. As for the sensorimotor network (SMN), patients with LA also have impaired sensorimotor integration caused by interfering with the communication or coordination of these aforementioned regions related to the SMN [19].…”

Section: Resting-state Fmri(rs-fmri)mentioning

confidence: 99%

Use of Multimodal Magnetic Resonance Imaging Techniques to Explore Cognitive Impairment in Leukoaraiosis

Yuan

Feng

et al. 2018

Med Sci Monit

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Leukoaraiosis, also referred to as white-matter hyperintensities (WMHs) or age-related white matter changes, is the most frequently seen lesion on brain magnetic resonance images (MRI) in the elderly. LA is a subject of intense research interest, and is correlated with stroke, cognitive impairment or dementia, disturbances, affective disorders, and poor prognoses. Rapid advances in neuroimaging have enabled greater understanding of LA associated with aging-related cognitive decline or dementia. Recently, the techniques of multimodal MRI, such as structural MRI (sMRI), resting-state functional MRI (rs-MRI), cerebrovascular reactivity (CVR), diffusion tensor imaging (DTI), magnetic resonance spectroscopy (MRS), and dynamic contrast-enhanced MRI (DCE-MRI), have been used to explore the underlying mechanism of cognitive impairment in patients with LA. These multimodal MRI techniques may provide further insights into the structural and functional changes of LA with cognitive dysfunction.

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Resting-state functional magnetic resonance imaging in patients with leukoaraiosis-associated subcortical vascular cognitive impairment: a cross-sectional study

Abstract: The present study provides neuroimaging evidence for the recognition of LA-associated SVCI. Moreover, the differences in the functional alterations of the resting-state DMN might be a distinguishing feature between SVCI and amnestic mild cognitive impairment patients.

Cited by 14 publications

References 30 publications

The Application of rs-fMRI in Vascular Cognitive Impairment

The Application of rs-fMRI in Vascular Cognitive Impairment

Functional Disorganization of Small-World Brain Networks in Patients With Ischemic Leukoaraiosis

Use of Multimodal Magnetic Resonance Imaging Techniques to Explore Cognitive Impairment in Leukoaraiosis

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