Resting State Functional Connectivity of the Rat Claustrum

Krimmel, Samuel R.; Qadir, Houman; Hesselgrave, Natalie; White, Margaret A.; Reser, David H.; Mathur, Brian N.; Seminowicz, David A.

doi:10.3389/fnana.2019.00022

Cited by 11 publications

(9 citation statements)

References 38 publications

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“…In contrast, shown in Figures 3E–G (see also bottom row of Supplementary Figure S2), a Cg cortex seed shows a strong connection specifically with the CLA in the awake state, but not insular cortex. This result is consistent with a recent rodent rs-fMRI study performed in a stronger magnetic field (7T), which reported that the CLA, but not insula, has functional connections with Cg cortex (Krimmel et al, 2019a).…”

Section: Introductionsupporting

confidence: 92%

“…Because of the close proximity between the CLA and the surrounding insula, results produced by attempts at dissociating the functional connectivity between these two structures, even with higher magnet strengths in rodent studies (4.7–7T), must be interpreted cautiously (see new method by Krimmel et al, 2019a). We attempted to isolate the CLA from the insula in our study through seed-based analysis in an fMRI with a stronger field strength that allows for smaller voxel size.…”

Section: Introductionmentioning

confidence: 99%

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A Role for the Claustrum in Salience Processing?

et al. 2019

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The claustrum (CLA) is a subcortical structure, present only in mammals, whose function remains uncertain. Previously, using resting-state functional magnetic resonance imaging (rs-fMRI) in awake head-fixed rats, we found evidence that the CLA is part of the rodent homolog of the default mode network (DMN; Smith et al., 2017 ). This network emerged as strong functional connections between the medial prefrontal cortex (mPFC), mediodorsal (MD) thalamus, and CLA in the awake state, which was not present following administration of isoflurane anesthesia. In the present report, we review evidence indicating that the rodent CLA also has connections with structures identified in the rodent homolog of the salience network (SN), a circuit that directs attention towards the most relevant stimuli among a multitude of sensory inputs (Seeley et al., 2007 ; Menon and Uddin, 2010 ). In humans, this circuit consists of functional connections between the anterior cingulate cortex (ACC) and a region that encompasses both the CLA and insular cortex. We further go on to review the similarities and differences between the functional and anatomical connections of the CLA and insula in rodents using both rs-fMRI and neuroanatomical tracing, respectively. We analyze in detail the connectivity of the CLA with the cingulate cortex, which is a major node in the SN and has been shown to modulate attention. When considered with other recent behavior and physiology studies, the data reveal a role for the CLA in salience-guided orienting. More specifically, we hypothesize that limbic information from mPFC, MD thalamus, and the basolateral amygdala (BLA) are integrated by the CLA to guide modality-related regions of motor and sensory cortex in directing attention towards relevant (i.e., salient) sensory events.

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Section: Introductionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

A Role for the Claustrum in Salience Processing?

et al. 2019

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“…Recent advances in rodent and human imaging now also enable further isolation of claustral and insular activity. 130 , 131 Notably, the insula has been identified as a potential deep brain stimulation target for treatment of pain 132 , 133 ; it is possible that electrodes inserted for this purpose also have contacts within the claustrum or affect it via downstream activation. Despite the challenges of isolating claustrum activity during MRI, several studies of human brain activity during various modalities of experimentally induced pain report increased activity in the claustrum, among many other regions.…”

Section: Re-evaluating the Function Of The Claustrummentioning

confidence: 99%

Human lesions and animal studies link the claustrum to perception, salience, sleep and pain

Atilgan

Doody

Oliver

et al. 2022

Brain

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The claustrum is the most densely interconnected region in the human brain. Despite the accumulating data from clinical and experimental studies, the functional role of the claustrum remains unknown. Here, we systematically review claustrum lesion studies and discuss their functional implications. Claustral lesions are associated with an array of signs and symptoms, including changes in cognitive, perceptual and motor abilities; electrical activity; mental state; and sleep. The wide range of symptoms observed following claustral lesions do not provide compelling evidence to support prominent current theories of claustrum function such as multisensory integration or salience computation. Conversely, the lesions studies support the hypothesis that the claustrum regulates cortical excitability. We argue that the claustrum is connected to, or part of, multiple brain networks that perform both fundamental and higher cognitive functions. As a multifunctional node in numerous networks, this may explain the manifold effects of claustrum damage on brain and behaviour.

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“…It will be important for future studies to better delineate the precise roles of the claustrum and divisions of the insula, as well as their interactions, in pain. Recent advances in rodent imaging now also enable further isolation of claustral and insular activity (Krimmel, Qadir, et al, 2019;. Notably, the insula has been identified as a potential deep brain stimulation target for treatment of pain (Segerdahl et al, 2015;Galhardoni et al, 2019); it is possible that electrodes inserted for this purpose also have contacts within the claustrum or affect it via downstream activation.…”

Section: Painmentioning

confidence: 99%

Does the claustrum have a function? Lessons from human lesion and animal studies point to divergent multifunctionality

Atilgan¹,

Doody²,

Oliver³

et al. 2021

Preprint

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The claustrum is the most densely interconnected region in the human brain. Despite the accumulating data from clinical and experimental studies, the functional role(s) of the claustrum remain unknown. Here, we systematically review claustrum lesion studies and discuss their functional implications. Claustral lesions are associated with an array of signs and symptoms, including changes in cognitive, perceptual and motor abilities; electrical activity; mental state; and sleep. The wide range of symptoms observed following claustral lesions suggests that the claustrum may either have a number of distinct functions, or a global function that impacts many neural processes. We further discuss the implications of these lesions in the context of recent evidence linking the claustrum to sensory perception, sleep, and salience as well as highlighting an underexplored link between the claustrum and pain. We hypothesize that the claustrum is connected to multiple brain networks, both ancient and advanced, which underly fundamental functions as well as higher cognitive processes. Extensive evidence derived from human lesion studies and animal experiments provides unequivocal evidence for a key function of the claustrum as a multifunctional node in numerous networks.

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Resting State Functional Connectivity of the Rat Claustrum

Cited by 11 publications

References 38 publications

A Role for the Claustrum in Salience Processing?

A Role for the Claustrum in Salience Processing?

Human lesions and animal studies link the claustrum to perception, salience, sleep and pain

Does the claustrum have a function? Lessons from human lesion and animal studies point to divergent multifunctionality

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