Resting State Functional Connectivity between Dorsal Attentional Network and Right Inferior Frontal Gyrus in Concussed and Control Adolescents

Suss, Stephen J.; Manelis, Anna; Santos, João Paulo Lima; Holland, Cynthia L.; Stiffler, Richelle; Bitzer, Hannah B.; Mailliard, Sarrah; Shaffer, Madelyn; Caviston, Kaitlin; Collins, Michael W.; Phillips, Mary L.; Kontos, Anthony P.; Versace, Amelia

doi:10.3390/jcm11092293

Cited by 5 publications

(5 citation statements)

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“…Moreover, the inferior frontal gyrus was found to be of special importance for inhibitory control of motor responses and impaired network integrity of the inferior frontal gyrus was related to vigorous physical activity ( Kullmann et al, 2014 ). Therefore, in study, increased nodal global efficiency in the left inferior frontal gyrus (opercular part), which had been shown to be crucial in the control of body movements ( Kullmann et al, 2014 ; Suss et al, 2022 ), might facilitate more efficient information transfer by greater functional connectivity with brain regions related to motor function in the brain (such as other areas of the frontal lobe, precentral and postcentral gyrus, somatosensory cortex) of male rowing athletes received tDCS.…”

Section: Discussionmentioning

confidence: 98%

Functional whole-brain mechanisms underlying effects of tDCS on athletic performance of male rowing athletes revealed by resting-state fMRI

Xu²,

Xiang³

et al. 2022

Front. Psychol.

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IntroductionTranscranial direct current stimulation (tDCS) is a noninvasive brain stimulation technique that applied to modulate brain activity and enhance motor recovery. However, the neurobiological substrates underlying the effects of tDCS on brain function remain poorly understood. This study aimed to investigate the central mechanisms of tDCS on improving the athletic performance of male rowing athletes.MethodsTwelve right-handed male professional rowing athletes received tDCS over the left primary motor cortex while undergoing regular training. The resting-state functional magnetic resonance imaging (rs-fMRI) data were acquired before and after tDCS. Measures of amplitude of low-frequency fluctuation (ALFF) and regional homogeneity (ReHo) were calculated and compared between baseline and follow-up, as well as topological measures including global and local efficiency of functional brain networks constructed by graph theoretical analysis.ResultsMale rowing athletes showed increased isokinetic muscle strength of the left knee and left shoulder after tDCS. Increased ALFF values were found in the right precentral gyrus of male rowing athletes after tDCS when compared with those before tDCS. In addition, male rowing athletes showed increased ReHo values in the left paracentral lobule following tDCS. Moreover, increased nodal global efficiency was identified in the left inferior frontal gyrus (opercular part) of male rowing athletes after tDCS.ConclusionThe findings suggested that simultaneous tDCS-induced excitation over the primary motor cortex might potentially improve the overall athletic performance in male rowing athletes through the right precentral gyrus and left paracentral lobule, as well as left inferior frontal gyrus.

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Section: Discussionmentioning

confidence: 98%

Functional whole-brain mechanisms underlying effects of tDCS on athletic performance of male rowing athletes revealed by resting-state fMRI

Xu²,

Xiang³

et al. 2022

Front. Psychol.

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“…In our study, the inability to activate the LIFG for the 2-back condition was associated with slower RT and lower accuracy in concussed adolescents in the subacute period. Our previous resting-state functional connectivity study indicated that unlike HC showing connectivity between the IFG and dorsal attention network, concussed adolescents demonstrated no such connectivity [44]. Disconnection of the IFG from the attentional network may serve to avoid a ‘chain reaction’ and, consequently, more massive cognitive impairments when the IFG becomes dysfunctional.…”

Section: Discussionmentioning

confidence: 99%

Working memory recovery in adolescents with concussion: Longitudinal fMRI study

Manelis,

Lima Santos,

Suss

et al. 2024

Preprint

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Background: Understanding behavioral and neural underpinnings of post-concussion recovery of working memory function is critically important for improving clinical outcomes and adequately planning return-to-activity decisions. Previous studies provided inconsistent results due to small sample sizes and the use of a mixed population of participants who were at different post-injury time points. Methods: To better understand behavioral and neural correlates of working memory recover during the first 6 months post-concussion, we used functional magnetic resonance imaging (fMRI) to scan 45 concussed adolescents [CONC] at baseline (<10 days post-concussion) and again at 6 months post-concussion. Healthy control [HC] adolescents without a history of concussion were scanned once. During the scans, participants performed 1-back (easy) and 2-back (difficult) working memory tasks with the letters as the stimuli and angry, happy, neutral, and sad faces as distractors. Results: By the 6-month follow-up, all affected adolescents were asymptomatic and cleared to return-to-activity. Working memory function recovery was reflected by faster and more accurate performance at 6 months vs. baseline (p-values<0.05). It was also characterized by significant difficulty-related activation increases in the left inferior frontal gyrus (LIFG) and the left orbitofrontal cortex (LOFC) at 6 months vs. baseline. Conclusion: Post-concussion recovery is associated with significant performance improvements in speed and accuracy, as well as normalization of brain responses in the LIFG and LOFC during the n-back task. The observed patterns of LOFC activation might reflect compensatory strategies to distribute neural processing and reduce neural fatigue post-concussion.

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“…In our study, the inability to activate the LIFG for the two-back condition was associated with a slower RT and lower accuracy in concussed adolescents in the subacute period. Our previous resting-state functional connectivity study indicated that unlike HCs showing connectivity between the IFG and dorsal attention network, concussed adolescents demonstrated no such connectivity [ 47 ]. Disconnection of the IFG from the attentional network may serve to avoid a ‘chain reaction’ and, consequently, more massive cognitive impairments when the IFG becomes dysfunctional.…”

Section: Discussionmentioning

confidence: 99%

Working Memory Recovery in Adolescents with Concussion: Longitudinal fMRI Study

Manelis,

Lima Santos,

Suss

et al. 2024

JCM

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Background: Understanding the behavioral and neural underpinnings of the post-concussion recovery of working memory function is critically important for improving clinical outcomes and adequately planning return-to-activity decisions. Previous studies provided inconsistent results due to small sample sizes and the use of a mixed population of participants who were at different post-injury time points. We aimed to examine working memory recovery during the first 6 months post-concussion in adolescents. Methods: We used functional magnetic resonance imaging (fMRI) to scan 45 concussed adolescents [CONCs] at baseline (<10 days post-concussion) and at 6 months post-concussion. Healthy control adolescents [HCs; n = 32] without a history of concussion were scanned once. During the scans, participants performed one-back and two-back working memory tasks with letters as the stimuli and angry, happy, neutral, and sad faces as distractors. Results: All affected adolescents were asymptomatic and cleared to return to activity 6 months after concussion. Working memory recovery was associated with faster and more accurate responses at 6 months vs. baseline (p-values < 0.05). It was also characterized by significant difficulty-related activation increases in the left inferior frontal gyrus (LIFG) and the left orbitofrontal cortex (LOFC) at 6 months vs. baseline. Although the activation differences between one-back and two-back were comparable between HCs and CONCs at 6 months, HCs had more pronounced activation in the LIFG than concussed adolescents. Conclusions: Post-concussion recovery is associated with significant performance improvements in speed and accuracy, as well as the normalization of brain responses in the LIFG and LOFC during the n-back task. The observed patterns of LOFC activation might reflect compensatory strategies to distribute neural processing and reduce neural fatigue post-concussion.

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Resting State Functional Connectivity between Dorsal Attentional Network and Right Inferior Frontal Gyrus in Concussed and Control Adolescents

Cited by 5 publications

References 40 publications

Functional whole-brain mechanisms underlying effects of tDCS on athletic performance of male rowing athletes revealed by resting-state fMRI

Functional whole-brain mechanisms underlying effects of tDCS on athletic performance of male rowing athletes revealed by resting-state fMRI

Working memory recovery in adolescents with concussion: Longitudinal fMRI study

Working Memory Recovery in Adolescents with Concussion: Longitudinal fMRI Study

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