Resting state functional connectivity and cognitive task-related activation of the human claustrum

Krimmel, Samuel R.; White, Margaret A.; Panicker, Matthew H.; Barrett, Frederick S.; Mathur, Brian N.; Seminowicz, David A.

doi:10.1016/j.neuroimage.2019.03.075

Cited by 58 publications

(98 citation statements)

References 48 publications

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“…However, this can still be problematic because some evidence suggests that the CLA may be embedded in layer 6 of insular cortex (Mathur et al, 2009; Mathur, 2014). In support of our findings, a recent study using stronger magnetic fields (7T) for rs-MRI in humans found strong functional connections between the CLA and cingulate cortex, though they did not interrogate differences between claustrum and insula connections (Krimmel et al, 2019b). Thus, more work is needed to precisely clarify the structural and functional connectional differences between CLA and insula, particularly in animal models with a well delineated CLA, such as non-human primates.…”

Section: Introductionsupporting

confidence: 88%

A Role for the Claustrum in Salience Processing?

et al. 2019

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The claustrum (CLA) is a subcortical structure, present only in mammals, whose function remains uncertain. Previously, using resting-state functional magnetic resonance imaging (rs-fMRI) in awake head-fixed rats, we found evidence that the CLA is part of the rodent homolog of the default mode network (DMN; Smith et al., 2017 ). This network emerged as strong functional connections between the medial prefrontal cortex (mPFC), mediodorsal (MD) thalamus, and CLA in the awake state, which was not present following administration of isoflurane anesthesia. In the present report, we review evidence indicating that the rodent CLA also has connections with structures identified in the rodent homolog of the salience network (SN), a circuit that directs attention towards the most relevant stimuli among a multitude of sensory inputs (Seeley et al., 2007 ; Menon and Uddin, 2010 ). In humans, this circuit consists of functional connections between the anterior cingulate cortex (ACC) and a region that encompasses both the CLA and insular cortex. We further go on to review the similarities and differences between the functional and anatomical connections of the CLA and insula in rodents using both rs-fMRI and neuroanatomical tracing, respectively. We analyze in detail the connectivity of the CLA with the cingulate cortex, which is a major node in the SN and has been shown to modulate attention. When considered with other recent behavior and physiology studies, the data reveal a role for the CLA in salience-guided orienting. More specifically, we hypothesize that limbic information from mPFC, MD thalamus, and the basolateral amygdala (BLA) are integrated by the CLA to guide modality-related regions of motor and sensory cortex in directing attention towards relevant (i.e., salient) sensory events.

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Section: Introductionsupporting

confidence: 88%

A Role for the Claustrum in Salience Processing?

et al. 2019

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“…This study also reported functional connectivity between the claustrum and posterior cingulate cortex, precuneus, angular gyrus, cuneus, visual cortex, and sensorimotor cortex, as well as with subcortical structures such as thalamus and nucleus accumbens among others (Krimmel et al, 2019).…”

Section: Introductionsupporting

confidence: 59%

“…The claustrum literature -including studies in animal model and in humans -has evidenced the vast anatomical connections between the claustrum and the entire cerebral cortex as well as with the subcortical structures (Eldestein & Denaro, 2004;Fernández-Miranda et al, 2008;Torgerson and Van Horn, 2014;Mathur 2014;Milardi et al, 2015;Goll et al, 2015;Qadir et al, 2018); and more recently Krimmel et al, (2019) contributed to this goal, examining the functional connectivity of the claustrum. Nevertheless, we do not have a clear or complete understanding on the function of the claustrum beyond of the theoretical proposals (Eldestein & Denaro, 2004;Crick & Koch, 2005;Goll et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

The functional connectivity of the human claustrum according to the Human Connectome Project database

Rodríguez-Vidal

Alcauter

Barrios

2019

Preprint

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The claustrum is an irregular and fine sheet of grey matter in the basolateral telencephalon present in almost all mammals. The claustrum has been the object of several studies using animal models and more recently in human beings using neuroimaging. It has been involved in cognition and disease such as fear recognition, suppression of natural urges, multisensory integration, conceptual integration, seizures, multiple sclerosis and Parkinsons disease. Nevertheless, the function of the claustrum still remains unclear. We present a high resolution functional connectivity study of the claustrum in order to identify its main networks. Resting state functional and anatomical MRI data from 40 healthy subjects were analyzed; taken from the Human Connectome Project (HCP, NIH Bleuprint: The Human Connectome Project), with 2x2x2 mm3 voxel resolution, equivalent to the high resolution tractography studies. Positive functional connectivity was found (p<0.05, FDR corrected) between the claustrum and the insula, anterior cingulate cortex, pre-central and postcentral gyrus, superior temporal gyrus and subcortical areas. Our findings coincide with the results previously reported in both animal models and studies with humans. Showing the claustrum as a profusely connected structure not only structurally but also functionally. Evidencing the claustrum as a node participating in a plethora neural networks.

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“…Future application of this novel approach using multiple datasets may shed light on which neural mechanisms, such as increased DMN entropy 40 , disruption of thalamocortical circuits 55 , or disruption of claustrocortical circuits 56 are common among or unique between different hallucinogens. Investigation of the claustrum, a structure thought to contribute to consciousness and delusional states, may especially be a fruitful avenue for future work considering the high expression of 5-HT 2A , NMDA, and κ-opioid receptors in the claustrum [57][58][59] and given recent developments in measuring claustrum function in humans using fMRI 60,61 . One of the most robust effects of salvinorin A was a decrease in sFC within the DMN, and using connectomebased classification, we found within-DMN sFC and eFC to be especially predictive of the effects of SA on brain function compared to other network interactions.…”

Section: Discussionmentioning

confidence: 99%

The Acute Effects of the Atypical Dissociative Hallucinogen Salvinorin A on Functional Connectivity in the Human Brain

Doss

May

Johnson

et al. 2020

Sci Rep

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Salvinorin A (SA) is a κ-opioid receptor agonist and atypical dissociative hallucinogen found in Salvia divinorum. Despite the resurgence of hallucinogen studies, the effects of κ-opioid agonists on human brain function are not well-understood. This placebo-controlled, within-subject study used functional magnetic resonance imaging for the first time to explore the effects of inhaled SA on strength, variability, and entropy of functional connectivity (static, dynamic, and entropic functional connectivity, respectively, or sFC, dFC, and eFC). SA tended to decrease within-network sFC but increase between-network sFC, with the most prominent effect being attenuation of the default mode network (DMN) during the first half of a 20-min scan (i.e., during peak effects). SA reduced brainwide dFC but increased brainwide eFC, though only the former effect survived multiple comparison corrections. Finally, using connectome-based classification, most models trained on dFC network interactions could accurately classify the first half of SA scans. In contrast, few models trained on within- or between-network sFC and eFC performed above chance. Notably, models trained on within-DMN sFC and eFC performed better than models trained on other network interactions. This pattern of SA effects on human brain function is strikingly similar to that of other hallucinogens, necessitating studies of direct comparisons.

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Resting state functional connectivity and cognitive task-related activation of the human claustrum

Cited by 58 publications

References 48 publications

A Role for the Claustrum in Salience Processing?

A Role for the Claustrum in Salience Processing?

The functional connectivity of the human claustrum according to the Human Connectome Project database

The Acute Effects of the Atypical Dissociative Hallucinogen Salvinorin A on Functional Connectivity in the Human Brain

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