Resting state functional atlas and cerebral networks in mouse lemur primates at 11.7 Tesla

Garin, Clément M.; Nadkarni, Nachiket A.; Landeau, Brigitte; Chételat, Gaël; Picq, Jean‐Luc; Bougacha, Salma; Dhénain, Marc

doi:10.1016/j.neuroimage.2020.117589

Cited by 12 publications

(14 citation statements)

References 77 publications

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“…Thirteen anaesthetized mouse lemurs were scanned using an EPI sequence on an 11.7T scanner ( Garin et al, 2021 ). Four common marmosets were scanned awake and anesthetized on a 9.4T scanner ( Hori et al, 2020a ).…”

Section: Resultsmentioning

confidence: 99%

“…The regional features of the human DMN are now well defined and encompass multiple, typical cerebral structures, such as the inferior parietal lobule (PG), the lateral temporal cortex, as well as two core regions: the posterior cingulate cortex (PCC) and the medial prefrontal cortex (mPFC) ( Buckner et al, 2008 ; Raichle et al, 2001 ). A homologous network to the DMN was proposed in multiple non-human primate species such as chimpanzees ( Barks et al, 2015 ), macaques ( Vincent et al, 2007 ), marmosets ( Belcher et al, 2013 ), and mouse lemurs ( Garin et al, 2021 ). Electrophysiological literature in macaques confirms that PCC firing rates are higher during resting baseline and are suppressed during task performance, consistent with a DMN-like role ( Hayden et al, 2009 ).…”

Section: Introductionmentioning

confidence: 99%

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An evolutionary gap in primate default mode network organization

et al. 2022

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

An evolutionary gap in primate default mode network organization

et al. 2022

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“…In addition, in the present study, the injections were performed into highly connected brain areas, such as the corpus callosum and the posterior cingulate cortex. The former is indeed the major commissural tract connecting both hemispheres and the latter is a functional connectivity hub in mouse lemurs [ 10 ]. Moreover, the cingulate cortex is involved in the default-mode network, which is disrupted and highly vulnerable to Aβ deposition in AD [ 5 ].…”

Section: Discussionmentioning

confidence: 99%

“…In the present study, we inoculated the posterior cingulate cortex and underlying corpus callosum of young adult mouse lemurs with either AD or control brain extracts. The posterior cingulate cortex was chosen as it is a functional cerebral hub in mouse lemurs [ 10 ]. The corpus callosum was chosen based on the assumption that migration of seeds could follow white matter tracts.…”

Section: Introductionmentioning

confidence: 99%

Transmission of amyloid-beta and tau pathologies is associated with cognitive impairments in a primate

Lam

Petit

Hérard

et al. 2021

acta neuropathol commun

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Amyloid-β (Aβ) pathology transmission has been described in patients following iatrogenic exposure to compounds contaminated with Aβ proteins. It can induce cerebral Aβ angiopathy resulting in brain hemorrhages and devastating clinical impacts. Iatrogenic transmission of tau pathology is also suspected but not experimentally proven. In both scenarios, lesions were detected several decades after the putatively triggering medico-surgical act. There is however little information regarding the cognitive repercussions in individuals who do not develop cerebral hemorrhages. In the current study, we inoculated the posterior cingulate cortex and underlying corpus callosum of young adult primates (Microcebus murinus) with either Alzheimer’s disease or control brain extracts. This led to widespread Aβ and tau pathologies in all of the Alzheimer-inoculated animals following a 21-month-long incubation period (n = 12) whereas none of the control brain extract-inoculated animals developed such lesions (n = 6). Aβ deposition affected almost all cortical regions. Tau pathology was also detected in Aβ-deposit-free regions distant from the inoculation sites (e.g. in the entorhinal cortex), while some regions adjacent, but not connected, to the inoculation sites were spared (e.g. the occipital cortex). Alzheimer-inoculated animals developed cognitive deficits and cerebral atrophy compared to controls. These pathologies were induced using two different batches of Alzheimer brain extracts. This is the first experimental demonstration that tau can be transmitted by human brain extracts inoculations in a primate. We also showed for the first time that the transmission of widespread Aβ and tau pathologies can be associated with cognitive decline. Our results thus reinforce the need to organize a systematic monitoring of individuals who underwent procedures associated with a risk of Aβ and tau iatrogenic transmission. They also provide support for Alzheimer brain-inoculated primates as relevant models of Alzheimer pathology.

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“…Previous studies have noted rich-club organization of neural structure centrality and network identification for the human ( van den Heuvel and Sporns, 2011 ; Grayson et al, 2014 ), and mouse brain ( de Reus and van den Heuvel, 2014 ; Coletta et al, 2020 ), as well as for a variety of other animal models: macaque ( Harriger et al, 2012 ); mouse lemurs ( Garin et al, 2021 ); cat ( Zamora-López et al, 2009 , 2010 , 2011 ; de Reus and van den Heuvel, 2013 ); avian ( Shanahan et al, 2013 ); and neural systems of nematodes ( C. elegans ) ( Towlson et al, 2013 ). For example, highly connected areas known as hubs tend to be densely interconnected, forming a “rich club” of brain areas ( Sporns et al, 2007 ; van den Heuvel and Sporns, 2011 ).…”

Section: Time-averaged Features Of Resting-state Functional Magnetic ...mentioning

confidence: 99%

Functional Connectivity of the Brain Across Rodents and Humans

LaGrow

Anumba

et al. 2022

Front. Neurosci.

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Resting-state functional magnetic resonance imaging (rs-fMRI), which measures the spontaneous fluctuations in the blood oxygen level-dependent (BOLD) signal, is increasingly utilized for the investigation of the brain’s physiological and pathological functional activity. Rodents, as a typical animal model in neuroscience, play an important role in the studies that examine the neuronal processes that underpin the spontaneous fluctuations in the BOLD signal and the functional connectivity that results. Translating this knowledge from rodents to humans requires a basic knowledge of the similarities and differences across species in terms of both the BOLD signal fluctuations and the resulting functional connectivity. This review begins by examining similarities and differences in anatomical features, acquisition parameters, and preprocessing techniques, as factors that contribute to functional connectivity. Homologous functional networks are compared across species, and aspects of the BOLD fluctuations such as the topography of the global signal and the relationship between structural and functional connectivity are examined. Time-varying features of functional connectivity, obtained by sliding windowed approaches, quasi-periodic patterns, and coactivation patterns, are compared across species. Applications demonstrating the use of rs-fMRI as a translational tool for cross-species analysis are discussed, with an emphasis on neurological and psychiatric disorders. Finally, open questions are presented to encapsulate the future direction of the field.

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Resting state functional atlas and cerebral networks in mouse lemur primates at 11.7 Tesla

Cited by 12 publications

References 77 publications

An evolutionary gap in primate default mode network organization

An evolutionary gap in primate default mode network organization

Transmission of amyloid-beta and tau pathologies is associated with cognitive impairments in a primate

Functional Connectivity of the Brain Across Rodents and Humans

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