Resting-State fMRI Associated with Stop-Signal Task Performance in Healthy Middle-Aged and Elderly People

Abstract

Several brain regions and connectivity networks may be altered as aging occurs. We are interested in investigating if resting-state functional magnetic resonance imaging (RS-fMRI) can also be valid as an indicator of individual differences in association with inhibition performance among aged (including middle-aged) people. Seventy-two healthy adults (40–77 years of age) were recruited. Their RS-fMRI images were acquired and analyzed via two cluster-analysis methods: local synchronization of spontaneous brain activity measured by regional homogeneity (ReHo) and fractional amplitude of low-frequency fluctuations (fALFF) of blood oxygenation level-dependent signals. After the RS-fMRI acquisition, participants were instructed to perform a stop-signal task, in which the stop signal reaction time (SSRT) was calculated based on the horse-race model. Among participants, the ReHo/fALFF and SSRT were correlated with and without partialling-out the effect of age. The results of this study showed that, although aging may alter brain networks, the spontaneous activity of the age-related brain networks can still serve as an effective indicator of individual differences in association with inhibitory performance in healthy middle-aged and elderly people. This is the first study to use both ReHo and fALFF on the same dataset for conjunction analyses showing the relationship between stopping performance and RS-fMRI in the elderly population. The relationship may have practical clinical applications. Based on the overall results, the current study demonstrated that the bilateral inferior frontal gyrus and parts of the default mode network activation were negatively correlated with SSRT, suggesting that they have crucial roles in inhibitory function. However, the pre-supplementary motor area (pre-SMA) and SMA played only a small role during the resting state in association with stopping performance.

Central Neural Correlates During Inhibitory Control in Lifelong Premature Ejaculation Patients

“…During the go/no-go task, abnormal activation in the left IFG was also found in smokers and healthy subjects, while patients with a left IFG lesion showed impaired control performance (Fassbender et al, 2004 ; Swick et al, 2008 ; Luijten et al, 2013 ). Even in resting-state, spontaneous activity in the left IFG was significantly correlated with SSRT (Tian et al, 2012 ; Lee and Hsieh, 2017 ). The bilateral IFG activation in response to inhibition process in both control and LPE groups also provides support that the process of control response may require the involvement of the left and right IFG together.…”

Between-module functional connectivity of the salient ventral attention network and dorsal attention network is associated with motor inhibition

“…Utilizing this paradigm, researchers have observed decreased motor inhibition in various clinical disorders, such as attention deficit hyperactivity disorder [5] and substance use disorders [6,7]. The deficiency in motor inhibition can also be found in normal aging [8][9][10][11][12][13].…”

Prediction of the Effect of Sleep Deprivation on Response Inhibition via Machine Learning on Structural Magnetic Resonance Imaging Data

“…Although the right-hemisphere dominance in activation is well-known, some studies have also reported bilateral activation in IFG, MFG, SMA and MTG (Li et al, 2006 ; Cohen et al, 2010 ; Congdon et al, 2014 ). Furthermore, Lee and Hsieh ( 2017 ) have found that the regional homogeneity/fractional amplitude of low-frequency fluctuation and SSRT were significantly negative correlated in the left IFG. The L_MFG and L_IFG_tri contributed the most to the coefficient of determination of the linear regression model in our present study.…”

“…Poor response inhibition may profoundly interfere with the requirements of everyday life. Inhibitory control is also an important function in individual daily activities, such as being able to stop driving upon seeing a pedestrian unexpectedly cross the road (Lee and Hsieh, 2017 ). However, sleep deprivation (SD) for one night can impair the performance of inhibitory control (Chuah et al, 2006 ; Zhao et al, 2018 ).…”