Resting-state EEG alpha/theta power ratio discriminates early-onset Alzheimer's disease from healthy controls

Özbek, Yağmur; Fide, Ezgi; Yener, Görsev

doi:10.1016/j.clinph.2021.05.012

Cited by 31 publications

(19 citation statements)

References 125 publications

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“…Other research consortia obtained similar results with rsEEG recordings in standard hospital settings. [41][42][43][44][45][46] A recent largescale clinical study in people diagnosed with subjective cognitive decline (SCD), MCI, and AD, found a significant correlation between increased delta and theta global field power (GFP; a single measure of the generalized EEG amplitude) and reduced global field synchronization (GFS; the global amount of instantaneous phase-locked synchronization of oscillating neuronal networks across the scalp) with lower CSF Aβ42 and higher p-tau and t-tau levels. 47 These findings implicate the usefulness of rsEEG features as early noninvasive biomarkers of AD.…”

Section: Discussionmentioning

confidence: 99%

What a Single Electroencephalographic (EEG) Channel Can Tell us About Alzheimer's Disease Patients With Mild Cognitive Impairment

Percio

Lopez

Noce³

et al. 2022

Clin EEG Neurosci

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Abnormalities in cortical sources of resting-state eyes closed electroencephalographic (rsEEG) rhythms recorded by hospital settings (10-20 montage) with 19 scalp electrodes characterized Alzheimer's disease (AD) from preclinical to dementia stages. An intriguing rsEEG application is the monitoring and evaluation of AD progression in large populations with few electrodes in low-cost devices. Here we evaluated whether the above-mentioned abnormalities can be observed from fewer scalp electrodes in patients with mild cognitive impairment due to AD (ADMCI). Clinical and rsEEG data acquired in hospital settings (10-20 montage) from 75 ADMCI participants and 70 age-, education-, and sex-matched normal elderly controls (Nold) were available in an Italian-Turkish archive (PDWAVES Consortium; www.pdwaves.eu ). Standard spectral fast fourier transform (FFT) analysis of rsEEG data for individual delta, theta, and alpha frequency bands was computed from 6 monopolar scalp electrodes to derive bipolar C3-P3, C4-P4, P3-O1, and P4-O2 markers. The ADMCI group showed increased delta and decreased alpha power density at the C3-P3, C4-P4, P3-O1, and P4-O2 bipolar channels compared to the Nold group. Increased theta power density for ADMCI patients was observed only at the C3-P3 bipolar channel. Best classification accuracy between the ADMCI and Nold individuals reached 81% (area under the receiver operating characteristic curve) using Alpha2/Theta power density computed at the C3-P3 bipolar channel. Standard rsEEG power density computed from six posterior bipolar channels characterized ADMCI status. These results may pave the way toward diffuse clinical applications in health monitoring of dementia using low-cost EEG systems with a strict number of electrodes in lower- and middle-income countries.

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Section: Discussionmentioning

confidence: 99%

What a Single Electroencephalographic (EEG) Channel Can Tell us About Alzheimer's Disease Patients With Mild Cognitive Impairment

Percio

Lopez

Noce³

et al. 2022

Clin EEG Neurosci

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“…A recent study dedicated to the detection of Alzheimer’s disease using EEG ( Özbek et al, 2021 ) showed that alpha and theta powers were higher in young than in the older healthy subject. All these might suggest that the oscillatory power increases observed after the RB session might reflect a positive outcome.…”

Section: Discussionmentioning

confidence: 99%

Effects of Pulsed-Wave Chromotherapy and Guided Relaxation on the Theta-Alpha Oscillation During Arrest Reaction

et al. 2022

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The search for the best wellness practice has promoted the development of devices integrating different technologies and guided meditation. However, the final effects on the electrical activity of the brain remain relatively sparse. Here, we have analyzed of the alpha and theta electroencephalographic oscillations during the realization of the arrest reaction (AR; eyes close/eyes open transition) when a chromotherapy session performed in a dedicated room [Rebalance (RB) device], with an ergonomic bed integrating pulsed-wave light (PWL) stimulation, guided breathing, and body scan exercises. We demonstrated that the PWL induced an evoked-related potential characterized by the N2-P3 components maximally recorded on the fronto-central areas and accompanied by an event-related synchronization (ERS) of the delta–theta–alpha oscillations. The power of the alpha and theta oscillations was analyzed during repeated ARs testing realized along with the whole RB session. We showed that the power of the alpha and theta oscillations was significantly increased during the session in comparison to their values recorded before. Of the 14 participants, 11 and 6 showed a significant power increase of the alpha and theta oscillations, respectively. These increased powers were not observed in two different control groups (n = 28) who stayed passively outside or inside the RB room but without any type of stimulation. These preliminary results suggest that PWL chromotherapy and guided relaxation induce measurable electrical brain changes that could be beneficial under neuropsychiatric perspectives.

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“…This suggests that the α/θ may be the strongest qEEG measure to discriminate patients with PD from healthy controls, as is observed with Alzheimer's disease. 22 The finding that lower AHI and higher min SpO2 during REM sleep were associated with increased risk of PD may seem counterintuitive, given the well-established links between obstructive sleep apnoea (OSA) and dementia, as well as additional evidence suggesting patients diagnosed with OSA may have an increased risk of PD. 23 However, the evidence linking OSA to increased PD risk is inconsistent.…”

Section: Discussionmentioning

confidence: 99%

“…This suggests that the α/θ may be the strongest qEEG measure to discriminate patients with PD from healthy controls, as is observed with Alzheimer’s disease. 22…”

Section: Discussionmentioning

confidence: 99%

“…9 The absolute and relative power of the EEG in different frequency bands throughout the night were computed for REM and non-REM (NREM) separately. In this analysis, the qEEG measures of interest included the mean relative power for the following frequency bands: δ (0.1 -4 Hz), θ (4 -8 Hz), α (8 -12 Hz), β (12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30) and γ (>30 Hz). In addition, using the absolute spectral power for α and θ, the α/θ power ratio (α/θ) -a synoptic index of EEG background slowing down -was calculated.…”

Section: Sleep Microstructure (Qeeg)mentioning

confidence: 99%

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Association of sleep abnormalities in older adults with risk of developing Parkinson’s disease

Otaiku

2022

Preprint

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BackgroundParkinson’s disease (PD) is associated with abnormalities of sleep macro- and microstructure as measured using polysomnography (PSG). Whether sleep abnormalities precede the development of PD is unknown. This study investigated the association between PSG measured sleep abnormalities in older adults and the risk of developing PD.Methods2,770 men aged 67 years or older from the ancillary sleep study of the Osteoporotic Fractures in Men Study (MrOS), a population-based cohort from the USA, who were free from PD at baseline (December 2003 – March 2005) and in whom there was PSG data available, were included in this analysis. Incident PD was based on a clinical diagnosis from a medical professional. Multivariable logistic regression was used to estimate odds ratios (OR) for incident PD by quartiles of PSG measures.FindingsDuring a median follow-up of 10.1 years, 70 (2.5%) cases of incident PD were identified. Longer total sleep time, lower rapid eye movement sleep (REM) percentage, a lower α/θ ratio during non-REM sleep and higher minimum oxygen saturations during REM sleep, were independently associated with an increased risk of developing PD during follow-up. Conversely, a higher awakening index was independently associated with a decreased risk of developing PD. The OR for the highest risk quartiles compared to the lowest risk quartiles, ranged from 2.3 to 4.0 (P < 0.05). The associations remained significant when incident PD cases occurring within the first two years of follow-up were excluded from the analyses.ConclusionsMacro- and microstructural sleep abnormalities precede the development of PD by several years and can identify individuals at high risk of developing PD in the future. Future studies are needed to determine whether sleep abnormalities represent preclinical markers of PD or causal risk factors.

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Resting-state EEG alpha/theta power ratio discriminates early-onset Alzheimer's disease from healthy controls

Cited by 31 publications

References 125 publications

What a Single Electroencephalographic (EEG) Channel Can Tell us About Alzheimer's Disease Patients With Mild Cognitive Impairment

What a Single Electroencephalographic (EEG) Channel Can Tell us About Alzheimer's Disease Patients With Mild Cognitive Impairment

Effects of Pulsed-Wave Chromotherapy and Guided Relaxation on the Theta-Alpha Oscillation During Arrest Reaction

Association of sleep abnormalities in older adults with risk of developing Parkinson’s disease

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