Resting-state connectivity of the amygdala predicts response to cognitive behavioral therapy in obsessive compulsive disorder

Göttlich, Martin; Krämer, Ulrike M.; Kordon, Andreas; Hohagen, Fritz; Zurowski, Bartosz

doi:10.1016/j.biopsycho.2015.09.004

Cited by 60 publications

(53 citation statements)

References 93 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Our finding that BLA-vmPFC functional connectivity is associated with CBT outcome is consistent with previous findings showing associations of BLA degree centrality with CBT outcome in a much smaller sample of patients with OCD 13 and of amygdala-prefrontal functional connectivity with CBT outcome in patients with SAD (although in the opposite direction).…”

Section: Discussionsupporting

confidence: 92%

“…Using rs-fc and an exploratory whole-brain approach, a recent study in patients with OCD found that the degree centrality (a generally accepted marker of functional connectivity) in the right BLA was positively associated with CBT outcome. 13 That study, however, did not assess connectivity at the network level (i.e., it did not provide information about con nectivity between the BLA and frontal regions). Moreover, it used a small sample (n = 17) and studied only inpatients with OCD, thus limiting the generalizability of the findings.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Basolateral amygdala–ventromedial prefrontal cortex connectivity predicts cognitive behavioural therapy outcome in adults with obsessive–compulsive disorder

Fullana

Zhu

Alonso

et al. 2017

JPN

View full text Add to dashboard Cite

Section: Discussionsupporting

confidence: 92%

mentioning

confidence: 99%

Basolateral amygdala–ventromedial prefrontal cortex connectivity predicts cognitive behavioural therapy outcome in adults with obsessive–compulsive disorder

Fullana

Zhu

Alonso

et al. 2017

JPN

View full text Add to dashboard Cite

“…Findings from these studies showed taskFC disruptions in OCD patients, also mainly in striatal and limbic regions (Jhung et al, 2014), with the latter showing connectivity disruptions in OCD also during rest (Anticevic et al, 2014, Beucke et al, 2013, Gottlich et al, 2014, Harrison et al, 2009). Moreover, alterations in limbic (i.e., amygdala) resting state functional connectivity (restFC) were found to be positively associated with response to treatment (i.e., CBT), underlining the potential relevance of limbic/amygdala disturbances for therapy outcome (Gottlich et al, 2015). …”

Section: Introductionmentioning

confidence: 99%

Functional and structural connectivity of the amygdala in obsessive-compulsive disorder

Rus

Reeß

Wagner

et al. 2017

NeuroImage: Clinical

View full text Add to dashboard Cite

BackgroundThe amygdala is known to be involved in anxiety processing, but its role in the psychopathology of obsessive-compulsive disorder (OCD) is still unclear.AimsIn this MRI study we investigated potential alterations in structural and functional connectivity of the amygdala in 42 adult patients with OCD and 37 healthy subjects.MethodPsychophysiological interaction analysis was used to explore amygdala functional connectivity during a negative affective task. Probabilistic tractography was then employed to study structural connectivity and integrity of underlying white matter fiber tracts.ResultsCompared to controls, OCD patients showed a significantly increased functional connectivity of the left amygdala with mostly parieto-occipital regions during task. No structural connectivity differences could be found between the groups. In addition, only patients showed a significant association between functional and structural connectivity of these regions. Moreover, symptom severity was negatively associated with structural integrity of the underlying white matter tracts.ConclusionsPresent results emphasize the relevance of the amygdala for OCD and may reflect that neuronal alterations in structural connectivity could be associated with functional connectivity alterations in broader networks.

show abstract

“…In contrast to traditional seeding approaches that need to select a particular region based on priori hypothesis, this voxel-based whole-brain correlation analysis could provide the opportunity for an unbiased general search of abnormalities within the entire connectivity matrix of full-brain functional connectome [20, 21]. DC calculation has been widely used to uncover mechanisms of other psychosomatic disorders, such as Alzheimer's disease [22], Schizophrenia [23], Parkinson's disease [24], obsessive compulsive disorder [25] and major depressive disorder [26]. In order to provide a new insight for mechanism detection of neurocognitive and emotional impairment in hyperthyroidism, we performed DC analysis to identify voxels that showed altered FC with other voxels.…”

Section: Introductionmentioning

confidence: 99%

Abnormal brain functional connectivity leads to impaired mood and cognition in hyperthyroidism: a resting-state functional MRI study

et al. 2016

View full text Add to dashboard Cite

Patients with hyperthyroidism frequently have neuropsychiatric complaints such as lack of concentration, poor memory, depression, anxiety, nervousness, and irritability, suggesting brain dysfunction. However, the underlying process of these symptoms remains unclear. Using resting-state functional magnetic resonance imaging (rs-fMRI), we depicted the altered graph theoretical metric degree centrality (DC) and seed-based resting-state functional connectivity (FC) in 33 hyperthyroid patients relative to 33 healthy controls. The peak points of significantly altered DC between the two groups were defined as the seed regions to calculate FC to the whole brain. Then, partial correlation analyses were performed between abnormal DC, FC and neuropsychological performances, as well as some clinical indexes. The decreased intrinsic functional connectivity in the posterior lobe of cerebellum (PLC) and medial frontal gyrus (MeFG), as well as the abnormal seed-based FC anchored in default mode network (DMN), attention network, visual network and cognitive network in this study, possibly constitutes the latent mechanism for emotional and cognitive changes in hyperthyroidism, including anxiety and impaired processing speed.

show abstract

Resting-state connectivity of the amygdala predicts response to cognitive behavioral therapy in obsessive compulsive disorder

Cited by 60 publications

References 93 publications

Basolateral amygdala–ventromedial prefrontal cortex connectivity predicts cognitive behavioural therapy outcome in adults with obsessive–compulsive disorder

Basolateral amygdala–ventromedial prefrontal cortex connectivity predicts cognitive behavioural therapy outcome in adults with obsessive–compulsive disorder

Functional and structural connectivity of the amygdala in obsessive-compulsive disorder

Abnormal brain functional connectivity leads to impaired mood and cognition in hyperthyroidism: a resting-state functional MRI study

Contact Info

Product

Resources

About