Resting state cerebral blood flow and objective motor activity reveal basal ganglia dysfunction in schizophrenia

Walther, Sebastian; Federspiel, Andrea; Horn, Helge; Razavi, Nadja; Wiest, Roland; Dierks, Thomas; Strik, Werner; Müller, Thomas

doi:10.1016/j.pscychresns.2010.12.002

Cited by 106 publications

(74 citation statements)

References 68 publications

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“…Neurobiological research using actigraphy suggests that the reduced AL found in patients with schizophrenia are linked to basal ganglia dysfunction, which may be compensated by increased involvement of cortical motor areas (i.e. the supplementary motor area and the cingulate cortex) in the control of their voluntary motor behaviour [5,6,7,8]. …”

Section: Introductionmentioning

confidence: 99%

Quantitative Psychomotor Dysfunction in Schizophrenia: A Loss of Drive, Impaired Movement Execution or Both?

et al. 2013

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Aims: The aim of the present study was to investigate the predictive value of qualitative psychomotor performance levels and subaspects of the negative syndrome for quantitative motor activity levels in patients with schizophrenia. Methods: Twenty-seven stabilized patients with schizophrenia and 22 age- and sex-matched healthy controls were included in the study. An extensive battery of psychomotor performance tests (Finger Tapping Test, Purdue Pegboard Test, Line Copying Test, Neurological Evaluation Scale, Salpêtrière Retardation Rating Scale), clinical rating scales (Positive and Negative Syndrome Scale) and 24-hour actigraphy were administered to all participants. Results: Correlational analyses showed that motor activity levels were associated with avolition as well as clinically assessed psychomotor slowing. However, in a regression model, only avolition was found to be a significant predictor for motor activity levels in patients with schizophrenia; none of the psychomotor performance tests nor the severity of emotional expressivity deficits contributed to the model. Conclusion: Qualitative and quantitative psychomotor deficits seem to be independent phenomena in stabilized patients with schizophrenia. The diminishing in motor activity in patients with schizophrenia is related to a loss of drive and not to problems in the quality of movement execution.

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Section: Introductionmentioning

confidence: 99%

Quantitative Psychomotor Dysfunction in Schizophrenia: A Loss of Drive, Impaired Movement Execution or Both?

et al. 2013

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“…Impaired parahippocampal recruitment during visual-memory encoding has been reported in patients and their siblings 37 . In our review, two small studies with the same sample size found divergent results in this region: while Scheef et al 14 (N = 11) described increased rCBF in this brain region, Walther et al 35 (N = 11) found precisely the opposite. Again, evidence is not enough to determine the rCBF patterns in the parahippocampus of patients with schizophrenia.…”

Section: Divergent Resultsmentioning

confidence: 58%

“…Many studies report a variety of thalamic alterations in schizophrenia, but few have offered consistent findings 41 . Our review showed divergent results regarding the rCBF in the thalamus in schizophrenia, but the studies that found increased rCBF (Scheef et al 14 and Zhu et al 34 ), assessed a total of 111 patients against 30 patients assessed by Liu et al 42 and Walther et al 35 The evidence of increased rCBF in the thalamus of schizophrenia patients receives further support from a PET study 43 , but the discrepancies should be addressed by future research.…”

Section: Divergent Resultsmentioning

confidence: 73%

“…The assumption of an antipsychotic effect to explain these differences is tempting, but the answer remains elusive. Zhu et al 34 (N = 100) found increased rCBF in the left MTG, in contrast with Walther et al 35 (N = 11), who described a decrease in patients. It is possible that increased rCBF in the MTG of schizophrenia patients reflects greater effort to integrate various sensory cues, even passively while at rest.…”

Section: Divergent Resultsmentioning

confidence: 88%

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Arterial spin labeling in patients with schizophrenia: a systematic review

Guimarães¹,

Machado‐de‐Sousa²,

Crippa³

et al. 2016

Arch. Clin. Psychiatry (São Paulo)

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Background: Neuroimaging studies are an invaluable source of information about the physiopathology of schizophrenia. Arterial spin labeling (ASL) is a new magnetic resonance technique (MRI) that is able to effectively evaluate brain function without the use of radiation. Objective: To make a systematic review of studies using ASL to compare resting-state regional cerebral blood flow (rCBF) patterns in patients with schizophrenia and healthy controls. Methods: Original articles were searched for on PubMed, Scopus, Web of Science and PsycINFO electronic databases. The search terms used were 'arterial' , 'spin' , 'labeling' , and 'schizophrenia' . Only studies comparing resting-state rCBF were included, a qualitative synthesis was then performed. Results: Ten articles were included in the review among a total of 22. Decreased rCBF in schizophrenia patients was described in the anterior cingulate, cuneus, fusiform gyrus, frontal lobe, left middle frontal gyrus, inferior frontal gyrus, lingual gyrus, middle occipital gyrus, and parietal lobe. The putamen was the only region with increased rCBF in schizophrenia. Discussion: The evidence of the studies reviewed lends support to the concept of hipofrontality in schizophrenia. rCBF alterations were found in regions classically associated with schizophrenia. ASL seems to be valid, and reliable tool to assess schizophrenia.

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“…Depending on the disease subtype, psychopathology and medication, excessive motor agitation, reduced motor activity, even akinetic episodes are observed [6,[196][197][198][199][200]. Both the dopaminergic and the glutamatergic systems in the prefrontal and subcortical areas are involved in these abnormalities [201].…”

Section: Motor Activitymentioning

confidence: 99%

Development and characterization of chronic animal models of schizophrenia

Petrovszki¹

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Resting state cerebral blood flow and objective motor activity reveal basal ganglia dysfunction in schizophrenia

Cited by 106 publications

References 68 publications

Quantitative Psychomotor Dysfunction in Schizophrenia: A Loss of Drive, Impaired Movement Execution or Both?

Quantitative Psychomotor Dysfunction in Schizophrenia: A Loss of Drive, Impaired Movement Execution or Both?

Arterial spin labeling in patients with schizophrenia: a systematic review

Development and characterization of chronic animal models of schizophrenia

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