Resting Regional Cerebral Blood Flow and Gambling Task Performance in Cocaine-Dependent Subjects and Healthy Comparison Subjects

Abstract

Resting anterior cingulate and dorsolateral prefrontal cortex rCBF is significantly related to decision making, as assessed by the Gambling Task.

Impulsivity, Neural Deficits, and the Addictions

“…Tucker et al 102 also found a significant correlation between Gambling Task performance and anterior cingulate regional cerebral blood flow (rCBF) changes in cocainedependent subjects. Interestingly, however, the relationship was in the opposite direction as that reported by Adinoff et al, 100 i.e., increased anterior cingulate rCBF was correlated with poorer Gambling Task performance. Differences between these two studies may be explained by the testing of recently using cocaine-addicted subjects (last use 4.6 ± 3.1 days prior to testing) in the Adinoff et al study 100 vs. at least two weeks abstinence in the Tucker et al study.…”

“…Interestingly, however, the relationship was in the opposite direction as that reported by Adinoff et al, 100 i.e., increased anterior cingulate rCBF was correlated with poorer Gambling Task performance. Differences between these two studies may be explained by the testing of recently using cocaine-addicted subjects (last use 4.6 ± 3.1 days prior to testing) in the Adinoff et al study 100 vs. at least two weeks abstinence in the Tucker et al study. 102 Using fMRI, Paulus et al 120 demonstrated a relationship between anterior cingulate and DLPFC (among other regions) activity and outcome predictability during a two-choice decision task.…”

“…[92][93][94][95][96][97][98][99] Other groups, however, have not observed differences between substance use disordered patients and controls in Gambling Task performance. [100][101][102] In general, patients in the positive studies were typically studied shortly following active use and endorsed more than one drug of abuse. In contrast, the negative studies assessed abstinent, cocaine-addicted subjects.…”

“…Adinoff et al 100 have reported that performance on the Gambling Task was positively correlated with basal activity (by SPLCT) of the anterior cingulate and DLPFC in both cocaine-addicted and healthy control subjects. Using a similar paradigm.…”

Arterial Spin-Labeling in Routine Clinical Practice, Part 2: Hypoperfusion Patterns

“…[12][13][14] Certain antihypertensive agents and cocaine have also been shown to decrease resting cerebral perfusion, though recent studies have demonstrated preservation of CBF during short-and long-term treatment of moderate hypertension. 15,16 Brain Death. ASL is sensitive in demonstrating states of hypoperfusion.…”