Resting heart rate is an independent predictor of advanced colorectal adenoma recurrence

Park, Jihye; Kim, Jae Hyun; Park, Yehyun; Park, Soo Jung; Cheon, Jae Hee; Park, Ji Soo; Jeon, Justin Y.; Kim, Tae Il

doi:10.1371/journal.pone.0193753

Cited by 21 publications

(23 citation statements)

References 37 publications

(35 reference statements)

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“…The association was stronger in low‐risk groups, and significant joint association was found between RHR and other known risk factors in respect to T2D risk. Taken together with accumulating evidence suggesting the usefulness of RHR as a diagnostic tool for several chronic diseases and a prognostic tool for patients, our findings suggest that RHR has a potential to be used independently, and in addition to other known risk factors, to predict future T2D in the clinical settings.…”

Section: Discussionmentioning

confidence: 99%

Resting heart rate and risk of type 2 diabetes: A prospective cohort study and meta‐analysis

Lee

Rezende

et al. 2018

Diabetes Metabolism Res

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Background Positive association between resting heart rate (RHR) and risk of type 2 diabetes (T2D) has been documented in several studies. However, whether RHR is an independent predictor of T2D and its potential interaction with other risk factors of T2D remain unclear. Methods We conducted a prospective cohort study of 31 156 men from the Health Professionals Follow‐up Study (1992‐2012). Cox proportional hazard model was used to examine the association between RHR and T2D risk. We further examined whether this association is modified by known risk factors. Lastly, we conducted a meta‐analysis of prospective cohort studies. Results During 505 380 person‐years of follow‐up, we identified 2338 incident T2D cases. The multivariable‐adjusted hazard ratio (HR) comparing the highest vs lowest categories of RHR was 1.69 (95% confidence interval [CI], 1.43‐2.01). Increase in 10 bpm of RHR was associated with 19% increased risk of T2D in the fully adjusted model (HR, 1.19; 95% CI, 1.14‐1.24). The HRs of T2D associated with RHR were stronger among those with normal weight or without hypertension (P interaction < 0.001). Moreover, RHR with other known risk factors cumulatively increased T2D risk. A meta‐analysis consistently showed a positive association between RHR and T2D risk (the summary relative risk [RR] for highest vs lowest RHR, 1.53; 95% CI, 1.26‐1.86, n = 12, the summary RR per 10 bpm increase, 1.17; 95% CI, 1.09‐1.26, n = 13). Conclusions High RHR was independently associated with increased risk of T2D. Our findings suggest that RHR, with other known risk factors, could be a useful tool to predict T2D risk.

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Section: Discussionmentioning

confidence: 99%

Resting heart rate and risk of type 2 diabetes: A prospective cohort study and meta‐analysis

Lee

Rezende

et al. 2018

Diabetes Metabolism Res

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“…In addition to radiotherapy, chemotherapy can also induce autonomic dysfunction: anthracyclines, trastuzumab, taxanes and cyclophosphamide are able to induce an increase in basal heart rate. The raised level of circulating catecholamine levels was demonstrated before a detectable reduction of EF [ 116 ]; obviously, the onset of overt HF can accentuate it. Additional conditions modulating the autonomic dysfunction are psychosocial stress, alterations in sleep patterns, weight gain (sarcopenic obesity) and low fitness.…”

Section: Exercise-induced Protective Effect On Radiotherapy Damagementioning

confidence: 99%

Oncology and Cardiac Rehabilitation: An Underrated Relationship

Venturini

Iannuzzo

D’Andrea

et al. 2020

JCM

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Cancer and cardiovascular diseases are globally the leading causes of mortality and morbidity. These conditions are closely related, beyond that of sharing many risk factors. The term bidirectional relationship indicates that cardiovascular diseases increase the likelihood of getting cancer and vice versa. The biological and biochemical pathways underlying this close relationship will be analyzed. In this new overlapping scenario, physical activity and exercise are proven protective behaviors against both cardiovascular diseases and cancer. Many observational studies link an increase in physical activity to a reduction in either the development or progression of cancer, as well as to a reduction in risk in cardiovascular diseases, a non-negligible cause of death for long-term cancer survivors. Exercise is an effective tool for improving cardio-respiratory fitness, quality of life, psychological wellbeing, reducing fatigue, anxiety and depression. Finally, it can counteract the toxic effects of cancer therapy. The protection obtained from physical activity and exercise will be discussed in the various stages of the cancer continuum, from diagnosis, to adjuvant therapy, and from the metastatic phase to long-term effects. Particular attention will be paid to the shelter against chemotherapy, radiotherapy, cardiovascular risk factors or new onset cardiovascular diseases. Cardio-Oncology Rehabilitation is an exercise-based multi-component intervention, starting from the model of Cardiac Rehabilitation, with few modifications, to improve care and the prognosis of a patient’s cancer. The network of professionals dedicated to Cardiac Rehabilitation is a ready-to-use resource, for implementing Cardio-Oncology Rehabilitation.

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“…This was confirmed in a large retrospective cohort of 4786 patients with breast cancer 58 . A recent analysis in 305 advanced colorectal adenoma patients suggested higher adenoma recurrence rates in those patients with higher heart rates 59 . These effects might be related to a sympathetic activation in some patients, like it has been shown for HF 60 .…”

Section: Cardiovascular Disease In Cancermentioning

confidence: 99%

Recent advances in cardio‐oncology: a report from the ‘Heart Failure Association 2019 and World Congress on Acute Heart Failure 2019’

et al. 2019

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While anti-cancer therapies, including chemotherapy, immunotherapy, radiotherapy, and targeted therapy, are constantly advancing, cardiovascular toxicity has become a major challenge for cardiologists and oncologists. This has led to an increasing demand of cardio-oncology units in Europe and a growing interest of clinicians and researchers. The Heart Failure 2019 meeting of the Heart Failure Association of the European Society of Cardiology in Athens has therefore created a scientific programme that included four dedicated sessions on the topic along with several additional lectures. The major points that were discussed at the congress included the implementation and delivery of a cardio-oncology service, the collaboration among cardio-oncology experts, and the risk stratification, prevention, and early recognition of cardiotoxicity. Furthermore, sessions addressed the numerous different anti-cancer therapies associated with cardiotoxic effects and provided guidance on how to treat cancer patients who develop cardiovascular disease before, during, and after treatment.

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Resting heart rate is an independent predictor of advanced colorectal adenoma recurrence

Cited by 21 publications

References 37 publications

Resting heart rate and risk of type 2 diabetes: A prospective cohort study and meta‐analysis

Resting heart rate and risk of type 2 diabetes: A prospective cohort study and meta‐analysis

Oncology and Cardiac Rehabilitation: An Underrated Relationship

Recent advances in cardio‐oncology: a report from the ‘Heart Failure Association 2019 and World Congress on Acute Heart Failure 2019’

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