Resting energy expenditure in lung and colon cancer

Nixon, Daniel W.; Kutner, Michael; Heymsfield, Steven B.; Foltz, Ann T.; Carty, Chandra; Seitz, Susan; Casper, Katie; Evans, William K.; Jeejeebhoy, Khursheed N.; Daly, J.M.; Heber, David; Poppendiek, H.F.; Hoffman, Freddie Ann

doi:10.1016/0026-0495(88)90068-6

Cited by 47 publications

(19 citation statements)

References 16 publications

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“…In comparison with control groups, patients with malignant disease have been reported to have reduced, normal or elevated energy expenditure. [17][18][19] The metabolic abnormalities caused by cancer are shown in Figure 1.…”

Section: Introductionmentioning

confidence: 99%

Cancer cachexia-anorexia syndrome and skeletal muscle wasting

Jurdana

2009

Radiology and Oncology

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Section: Introductionmentioning

confidence: 99%

Cancer cachexia-anorexia syndrome and skeletal muscle wasting

Jurdana

2009

Radiology and Oncology

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“…The hypermetabolic response as a prognostic biomarker has been investigated in several diseases, such as liver cirrhosis, cancer, or sepsis [10, 11, 21, 22]. However, information in HBV-ACLF patients is very limited.…”

Section: Discussionmentioning

confidence: 99%

Persistently Increased Resting Energy Expenditure Predicts Short-Term Mortality in Patients with Acute-on-Chronic Liver Failure

et al. 2018

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Objective: Hypermetabolism based on measurements of resting energy expenditure (REE) is suggested to be a potential biomarker for predicting the clinical outcomes of some diseases. We aimed to evaluate the potential value of hypermetabolism for predicting the short-term (28-day) mortality of patients with hepatitis B virus-related acute-on-chronic liver failure (HBV-ACLF). Methods: A total of 105 HBV-ACLF patients, 30 chronic hepatitis B (CHB) patients and 30 healthy controls (HCs) were included in this study. The REE was measured using indirect calorimetry in the morning after 8–10 h of fasting. The predicted REE (REEHB) was determined using Harris-Benedict equation. Persistent hypermetabolism was defined as the REE:REEHB ratio > 1.20 at day 1 and day 7 after admission. The severity of liver disease was estimated using the Model for End-Stage Liver Disease (MELD). Clinical and biochemical variables were determined using blood samples ordered upon admission. These variables were compared between nonsurviving and surviving patients who were classified according to the 28-day mortality. Results: The frequency of hypermetabolism at baseline was significantly higher in ACLF patients than that in HCs and CHB patients. Forty-six (43.8%) ACLF patients died within follow-up of 28 days. Persistent hypermetabolism (OR 2.10; 95% CI 1.15–3.69; p = 0.002) and MELD score (OR 1.93; 95% CI 1.47–3.51; p = 0.012) were independent predictive indicators of 28-day mortality. Furthermore, the performance of the 2 variables (persistent hypermetabolism and MELD) together with the area under the receiver operating curve (AUROC: 0.819) was significantly better than that of MELD alone (AUROC: 0.694) for prediction of short-term mortality (p = 0.014). Conclusion: These findings indicate that persistent hypermetabolism is predictive of short-term mortality in this small population.

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“…In many cases an elevation of REE would be a reasonable explanation al though normo-and even hypometabolism can be observed [2][3][4][5][6][7]. With regard to the relation between resting energy ex penditure and weight loss as well as cachexia in cancer patients Nixon et al [5] provided several possible hypotheses: T. eleva tion of REE is part of the tumor-host relationship preceding cachexia, which may be delayed by an increase in calory in take, 2. REE remains normal but becomes relatively elevated by declining body weight.…”

Section: Discussionmentioning

confidence: 99%

Perioperative Changes in Body Composition and Metabolism in Patients with Colorectal Cancer according to Tumor Stage

Weirnann¹,

Raab²,

Selberg³

et al. 1996

Oncol Res Treat

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Background: Reports about the influence of curative and palliative tumor resection on metabolism and resting energy expenditure (REE) in colorectal carcinoma are controversial. This study deals with a group of patients with colorectal cancer of all tumor stages undergoing surgery for the primary. Special attention was attributed to the question whether perioperative changes of REE and body composition depend on tumor stage. Patients and Methods: In a prospective study 32 colorectal cancer patients undergoing surgery were investigated in order to compare nutritional status, body composition and metabolism according to tumor stage. In 18 patients with UICC tumor stages I-III the tumors could be completely removed and in 14 patients with stage IV there was persisting tumor mass as liver metastases after resection of the primary. 10 days pre- and post-operatively bioelectrical body impedance analysis (B.I.A.), indirect calori-metry as well as serum and urine analysis were performed. Results: According to tumor stages no significant inter-group difference was observed in body mass index and preoperative weight loss. Significant increase of extracellular/body cell mass ratio indicating an increase of extracellular mass and decrease of body cell mass was preoperatively found in patients with metastatic colorectal cancer. Correlation between the percentage of preoperative weight loss and extracellular/body cell mass ratio was found in patients with tumor stages I-III. Preoperatively, resting energy expenditure, substrate oxidation rates, serum albumin and trans-ferrin as well as urine 3-methylhistidine excretion were without significant differences between the two groups. After resection of the primary no shift towards hypermetabolism was found in patients with unresected metastases compared to those with complete tumor removal. Taking into account the effects of the surgical trauma itself, postoperatively a further increase of extracellular mass and decrease of body cell mass was observed. These changes led to significantly higher ratios of extracellular/body cell mass and resting energy expenditure/body cell mass in patients with metastatic disease. Resting energy expenditure, substrate oxidation rates, serum albumin and transferrin and urine 3-methylhistidine excretion did not reveal significant inter-group differences postoperatively. Conclusion: No difference in body mass index, resting energy expenditure, protein oxidation and 3-methylhistidine urinary excretion can be found in patients with colorectal cancer without and with liver metastases before and after resection of the primary. However, there are indicators for a perioperative higher decrease of body cell mass in patients with liver metastases and palliative resection of the primary. This might be partially attributed to peripheral protein mobilization and protein retention and synthesis by the tumor itself.

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Resting energy expenditure in lung and colon cancer

Cited by 47 publications

References 16 publications

Cancer cachexia-anorexia syndrome and skeletal muscle wasting

Cancer cachexia-anorexia syndrome and skeletal muscle wasting

Persistently Increased Resting Energy Expenditure Predicts Short-Term Mortality in Patients with Acute-on-Chronic Liver Failure

Perioperative Changes in Body Composition and Metabolism in Patients with Colorectal Cancer according to Tumor Stage

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