Resting Energy Expenditure and Metabolic Changes After Lung Volume Reduction Surgery for Emphysema

Mineo, Tommaso Claudio; Pompeo, Eugenio; Mineo, Davide; Ambrogi, Vincenzo; Ciarapica, Donatella; Polito, Angela

doi:10.1016/j.athoracsur.2006.05.030

Cited by 22 publications

(20 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…As previously reported, 13 the reduction in residual volume was significantly correlated with the increment of FFM ( ϭ Ϫ 0.49; p Ͻ 0.02) and FM ( ϭ Ϫ 0.55; p Ͻ 0.009). In addition, the reduction of residual volume was significantly correlated with the increase in ghrelin ( ϭ Ϫ 0.52; p Ͻ 0.01), with the reduction in leptin corrected for FM ( ϭ 0.50; p Ͻ 0.02), and only marginally with the decrease in the HOMA-IR ( ϭ 0.35; p ϭ 0.07).…”

Section: Correlation Analysissupporting

confidence: 68%

“…32 When compared to maximal medical and rehabilitation therapy, LVRS provides an immediate and prolonged improvement of functional indexes, static volumes, exercise capacity, nutritional status, and quality of life. 12,13 After LVRS, the amelioration of gas exchange capacity and the reduction of the oxygen cost of breathing were correlated with weight gain 33 and FFM recovery. 34,35 We also showed that improvements in body weight and composition, bone mineral density, and resting energy expenditure correlated with the surgical reduction of residual volume.…”

Section: Discussionmentioning

confidence: 99%

“…34,35 We also showed that improvements in body weight and composition, bone mineral density, and resting energy expenditure correlated with the surgical reduction of residual volume. 13,36,37 In this study, we evaluated whether LVRS could induce significant changes in glycolipidic hormone secretion, thus improving nutritional and clinical status. After LVRS, relevant changes in adipokine production were observed, suggesting a higher absolute secretion from the increased body fat content.…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Effects of Lung Volume Reduction Surgery for Emphysema on Glycolipidic Hormones*

Mineo

Ambrogi

Frasca

et al. 2008

Chest

Self Cite

View full text Add to dashboard Cite

services can be found online on the World Wide Web at:The online version of this article, along with updated information and Background: Pulmonary emphysema is associated with cachexia and disregulation of the hormones regulating the glycolipid metabolism, insulin resistance, and altered substrate utilization. This study aimed at identifying the effects of lung volume reduction surgery (LVRS) on glycolipidic hormones compared to respiratory rehabilitation (RR). Methods: Thirty-three patients with moderate-to-severe emphysema who were undergoing video-assisted thoracoscopic LVRS were compared to 31 similar patients who refused the operation and followed a standardized RR program. All patients were evaluated before and 12 months after treatment for respiratory function, body composition, glycolipidic hormones, metabolic parameters, and insulin resistance, which was calculated using the homeostatic model assessment index for insulin resistance (HOMA-IR). These groups were compared to a matched healthy control population.

show abstract

Section: Correlation Analysissupporting

confidence: 68%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Effects of Lung Volume Reduction Surgery for Emphysema on Glycolipidic Hormones*

Mineo

Ambrogi

Frasca

et al. 2008

Chest

Self Cite

View full text Add to dashboard Cite

show abstract

“…The LVRS patients continuing oral steroids experienced significant ameliorations compared with the RR patients, despite comparable dosage, as previously shown [13,15]; this observation persisted throughout the study period.…”

Section: Respiratory Evaluationsupporting

confidence: 63%

“…Respiratory muscles V9O 2 was calculated as the proportion of V9O 2 of respiratory muscles (V9O 2 ,Resp%) compared to total V9O 2 , using measured and predicted REE values. Measured REE and V9O 2 were then corrected for FFM [15].…”

Section: Energetic Metabolism Evaluationmentioning

confidence: 99%

Recovery of body composition improves long-term outcomes after lung volume reduction surgery for emphysema

Mineo

Ambrogi²,

Lauriola³

et al. 2010

European Respiratory Journal

View full text Add to dashboard Cite

Nutritional status deteriorates along with progression of emphysema, with the decline of body composition correlating with risk of disease-related events. Lung volume reduction surgery (LVRS), by improving respiratory function and recovering body composition, may influence long-term disease-related morbidity and mortality when compared to respiratory rehabilitation (RR).In this non-randomised study, 44 male patients with moderate-to-severe emphysema underwent LVRS, while 35 received RR. Respiratory parameters, body composition, number and time-tooccurrence of disease-related events were evaluated for 5 yrs.After LVRS, respiratory and nutritional parameters had significantly greater and longer lasting improvements than after RR. Disease-related events occurred later and less frequently after surgery than after rehabilitation, with better morbidity and mortality survival curves (p,0.01 and p,0.03, respectively). Body mass index (BMI) o23kg?m LVRS significantly and durably improved respiratory function and body composition over RR. Relationships among residual volume, BMI, FFMI and disease-related events suggest that recovery in respiratory dynamics improves nutritional status, thus significantly reducing longterm disease-related morbidity and mortality.

show abstract

Lung Transplantation and Lung Volume Reduction Surgery

Estenne

Fessler²,

DeCamp

2011

Comprehensive Physiology

View full text Add to dashboard Cite

Since the publication of the last edition of the Handbook of Physiology, lung transplantation has become widely available, via specialized centers, for a variety of end-stage lung diseases. Lung volume reduction surgery, a procedure for emphysema first conceptualized in the 1950s, electrified the pulmonary medicine community when it was rediscovered in the 1990s. In parallel with their technical and clinical refinement, extensive investigation has explored the unique physiology of these procedures. In the case of lung transplantation, relevant issues include the discrepant mechanical function of the donor lungs and recipient thorax, the effects of surgical denervation, acute and chronic rejection, respiratory, chest wall, and limb muscle function, and response to exercise. For lung volume reduction surgery, there have been new insights into the counterintuitive observation that lung function in severe emphysema can be improved by resecting the most diseased portions of the lungs. For both procedures, insights from physiology have fed back to clinicians to refine patient selection and to scientists to design clinical trials. This section will first provide an overview of the clinical aspects of these procedures, including patient selection, surgical techniques, complications, and outcomes. It then reviews the extensive data on lung and muscle function following transplantation and its complications. Finally, it reviews the insights from the last 15 years on the mechanisms whereby removal of lung from an emphysema patient can improve the function of the lung left behind.

show abstract

Resting Energy Expenditure and Metabolic Changes After Lung Volume Reduction Surgery for Emphysema

Cited by 22 publications

References 24 publications

Effects of Lung Volume Reduction Surgery for Emphysema on Glycolipidic Hormones*

Effects of Lung Volume Reduction Surgery for Emphysema on Glycolipidic Hormones*

Recovery of body composition improves long-term outcomes after lung volume reduction surgery for emphysema

Lung Transplantation and Lung Volume Reduction Surgery

Contact Info

Product

Resources

About