Resting cortical PET metabolic changes in psychogenic non-epileptic seizures (PNES)

Abstract

NCT00484523.

Neuroimaging studies in patients with psychogenic non-epileptic seizures: A systematic meta-review

“… Arthuis et al (2015) used interictal 18 FDG - PET to examine resting state brain metabolic alterations in PNES patients. 18 FDG or fludeoxyglucose F 18 is a radiopharmaceutical used in PET to assess tissue uptake of glucose, and can provide an indirect measure of brain metabolic function/activation.…”

White matter diffusion abnormalities in patients with psychogenic non-epileptic seizures

“…In the majority of cases SPECT results were negative, and in some cases a positive result was found, though the locations were not consistent across studies (Biraben et al, 1999;Ettinger et al, 1998;Neiman et al, 2009;Spanaki et al, 1999;Varma et al, 1996). Another study reported that group analysis of patients with PNES revealed significant PET hypometabolism within the right inferior parietal and central area, and within the bilateral anterior cingulate cortex (Arthuis et al, 2014). While making a direct correlation between these findings and the results of the present study is challenging, these reports are nonetheless supportive of the notion that differences between patients with PNES and HCs exist and may be observable with imaging.…”

Biological underpinnings of psychogenic nonepileptic seizures: directions for future research

“…Abnormal connectivity in patients with PNES may provide a neurophysiological correlate for the underlying dissociation mechanisms, allowing emotion to influence executive control and resulting in altered motor function (i.e., seizure-like episodes) [15]. Although recent imaging studies of the pathophysiology of PNES have included only small numbers of patients, even these small populations have shown statistically significant deviations compared to healthy controls [7][8][9][10][11][12][13][14][15][16][17][18]. Many of these studies reproduced similar findings.…”

“…However, recent evidences, including advanced EEG and imaging techniques, reveal that patients have specific neurobiological dysfunctions, specifically functional and structural brain connectivity abnormalities [6][7][8][9][10][11][12][13][14][15][16][17][18][19]. For example, functional imaging studies have shown evidence of altered functional and structural connectivity of brain networks in patients with PNES [20].…”