Resting blood lactate in individuals with sickle cell disease

Abstract

Resting blood lactate in individuals with sickle cell diseaseBackground: The most common hereditary hemoglobin disorder, affecting 20 million individuals worldwide, is sickle cell disease. The vascular obstruction resulting from the sickling of cells in this disease can produce local hypoxemia, pain crises and infarction in several tissues, including the bones, spleen, kidneys and lungs. Objective: To determine red blood group genes in a Brazilian populations. Methods:The present study is characterized as a case control study, with the aim of identifying the baseline blood lactate concentration in individuals with hemoglobin SS and SC diseases. One-way ANOVA with the Tukey post-test was used to analyze the results and a p-value < 0.05 was considered significant. Calculations were made using the INSTAT statistical program. The graphs were generated using the ORING program. The study sample was composed of 31 men and women residing in the city of Santo Antônio de Jesus, Bahia, Brazil. The individuals were divided into two groups: Group GC of 16 subjects who did not present with any type of structural hemoglobinopathy; and Group GE composed of 15 individuals with ages between 2 and 35 years old, who had the SS and SC genotypes. Sample analyses were performed with 3 mL of blood during fasting. Results: The baseline blood lactate concentration of the SS and SC individuals was higher than that of the control group (p<0.001) with means of 4.86 ± 0.95; 3.30 ± 0.33; 1.31 ± 0.08 IU/L for SS, SC and controls, respectively. This corroborates the initial research hypothesis. Conclusion:The baseline blood lactate of SS and SC individuals is 3 to 4 times higher than that of healthy subjects, probably due to the fact that these patients have a metabolic deviation to the anaerobic pathway.

Functional capacity and quality of life in children and adolescents with sickle cell anemia

“…Cardiorespiratory morbidity of SCA HbSS genotype contributes to functionality decreasing. 25,26 This can be associated with anthropometric variables such as weight and height, which were worse in patients of the SCAG compared with the control group. Some studies have shown that the resting energy expenditure of these patients is up to 20% higher when compared to healthy individuals, this is due to erythropoiesis, increased cardiac work, chronic hemolysis, and hypoxia in tissues.…”

The miR‐17~92 cluster activates mTORC1 in mantle cell lymphoma by targeting multiple regulators in the STK11/AMPK/TSC/mTOR pathway

“…Proline build-up could be due to increased synthesis or decreased breakdown by the enzymes proline oxidase or proline dehydrogenase (PRODH), respectively. As the level of lactate, an inhibitor of PRODH, is elevated in SCD patients compared to control subjects following a shift towards anaerobic metabolism (Petto et al, 2011), high lactate levels may contribute to the development of albuminuria in SCD via increased proline levels.…”