Restenosis: Repeat Narrowing of a Coronary Artery

Dangas, George; Kuepper, Frank

doi:10.1161/01.cir.0000019122.00032.df

Cited by 77 publications

(37 citation statements)

References 11 publications

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“…Postprocedure, restenosis due to neointimal proliferation of vascular smooth muscle cells represented another limiting factor most common in patients with diabetes and complex coronary artery disease (3)(4)(5).…”

Section: The Technique Was Limitedmentioning

confidence: 99%

Drug-eluting balloons with provisional bail-out or adjunctive stenting in de novo coronary artery lesions—a systematic review and meta-analysis

Patel

Svermova

Burke-Gaffney

et al. 2018

Cardiovasc. Diagn. Ther.

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Background: Efficacy of drug-eluting balloons (DEB) for treatment of de novo coronary lesions remains controversial. The present systematic review and meta-analysis of randomised controlled trials assessed DEB with bare-metal stents (BMS) and also DEB with provisional bail-out stents ('DEB-only' strategy), to other conventional options: plain-old balloon angioplasty (POBA), BMS and drug-eluting stents (DES). Conclusions:The results of this meta-analysis showed that whilst DEB with BMS is superior to BMS alone, the combination is inferior to DES for treatment of de novo coronary lesions. Thus, DEB + BMS should not be applied in de novo lesions unless in patients who have absolute contraindications to DES. DEB alone, however, should be considered for relative contraindications to DES such as small vessel disease and bifurcation lesions.

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Section: The Technique Was Limitedmentioning

confidence: 99%

Drug-eluting balloons with provisional bail-out or adjunctive stenting in de novo coronary artery lesions—a systematic review and meta-analysis

Patel

Svermova

Burke-Gaffney

et al. 2018

Cardiovasc. Diagn. Ther.

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“…The SMCs then undergo rapid proliferation which, in turn, results in re-narrowing of the artery or in-stent restenosis (ISR) [39][40][41][42][43][44]. On the other hand, thrombosis is induced by the activation of the intrinsic coagulation system and formation of blood clots on the stent surface, when plasma proteins and platelets adhere to the surface in the early period after stent deployment [45][46][47].…”

Section: Introductionmentioning

confidence: 99%

Electrochemical polishing as a 316L stainless steel surface treatment method: Towards the improvement of biocompatibility

et al. 2014

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“…However, restenosis after successful stent placement ranges from ~5–30% of total patients and increases the likelihood that patients will need further surgical procedures (Forte et al, 2009). Endothelial cell wasting is a significant problem that contributes to restenosis (Dangas et al, 2002). The morphology of the endothelium after stent placement typically reveals microinjuries and exposed basement membrane tissue (Oettgen et al, 2006).…”

Section: Discussionmentioning

confidence: 99%

Sry-type HMG box 18 contributes to the differentiation of bone marrow-derived mesenchymal stem cells to endothelial cells

2015

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Objective Mesenchymal stem cells (MSC) have shown therapeutic potential to engraft and either differentiate into or support differentiation of vascular endothelial cells (EC), smooth muscle cells and cardiomyocytes in animal models of ischemic heart disease. Following intracoronary or transendocardial delivery of MSCs, however, only a small fraction of cells engraft and the majority of those persist as an immature cell phenotype. The goal of the current study was to decipher the molecular pathways and mechanisms that control MSC differentiation into ECs. Vascular endothelial growth factor (VEGF-165) treatment is known to enhance in vitro differentiation of MSCs into ECs. We tested the possible involvement of the Sry-type HMG box (Sox) family of transcription factors in this process. Method and Results MSCs were isolated from the bone marrow of Yucatan microswine and underwent a 10 day differentiation protocol. VEGF-165 (50 ng/ml) treatment of MSCs in vitro induced a significant increase in the protein expression of VEGFR-2, Sox9 and Sox18, in addition to the EC markers PECAM-1, VE-cadherin and vWF, as determined by Western blot or flow cytometry. siRNA-mediated knockdown of Sox18, as opposed to Sox9, in MSCs prevented VEGF-165-mediated induction of EC markers and capillary tube formation. Inhibition of VEGFR-2 signaling (SC-202850) reduced Sox18 and reduced VEGF-165-induced differentiation of MSCs to ECs. Conclusion Here we demonstrate that VEGF-165 mediates MSC differentiation into ECs via VEGFR-2-dependent induction of Sox18, which ultimately coordinates the transcriptional upregulation of specific markers of the EC phenotype.

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Restenosis: Repeat Narrowing of a Coronary Artery

Cited by 77 publications

References 11 publications

Drug-eluting balloons with provisional bail-out or adjunctive stenting in de novo coronary artery lesions—a systematic review and meta-analysis

Drug-eluting balloons with provisional bail-out or adjunctive stenting in de novo coronary artery lesions—a systematic review and meta-analysis

Electrochemical polishing as a 316L stainless steel surface treatment method: Towards the improvement of biocompatibility

Sry-type HMG box 18 contributes to the differentiation of bone marrow-derived mesenchymal stem cells to endothelial cells

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