Restenosis after Successful Ostial Stent Implantation:

Abstract

Despite the introduction of coronary stents and effective anticoagulation regimens, the treatment of ostial lesions is limited by high restenosis rates. Initial results have been published asserting that statin therapy is associated with a significant reduction in restenosis after stent deployment. However, no information is available about the effect of statins after ostial stenting. Between 1993 and 2000, 122 patients required ostial placement of coronary stents at the Royal Brompton Hospital in London, United Kingdom. Statin treatment was continued or begun in 52 patients with a documentated hypercholesterolemia. Follow-up was feasible in 97 patients undergoing successful stent implantation. Restenosis rate was lower in patients receiving statins, but did not differ significantly from the nonstatin group (34.6% as against 42.2%, P = 0.531).

Use of Self-Expanding Stents for the Treatment of Vertebral Artery Ostial Stenosis: a Single Center Experience

“…The reported ISR rates with bare-metal BESs are between 35 and 45% (7, 8, 12, 13, 18, 19), which is approximately 10-15% greater than the rate with bare metal stenting in the coronary arteries and much greater than that after carotid stenting. This is consistent with the stenting results seen in coronary ostial lesions, which show almost two-fold higher ISR rates than usual non-ostial lesions (20, 21, 36). Considering those study results, our follow-up study showed the best long-term patency rate and durability.…”

Comparison of Self-Expanding Stents With Distal Embolic Protection to Balloon-Expandable Stents Without a Protection Device in the Treatment of Symptomatic Vertebral Artery Origin Stenosis

“…[18][19][20] The Stenting of Symptomatic Atherosclerotic Lesions in the Vertebral or Intracranial Arteries (SSYLVIA) study and various case series have reported relatively high ISR rates (20%-50%) during follow-up. [21][22][23][24][25][26] DES are also accompanied by high ISR rates in addition to stent fractures and requirement for long-term dual antiplatelet therapy. Furthermore, data with DES are limited and long-term follow-up is sparse.…”

Outcomes after percutaneous coronary intervention of ostial lesions in the era of drug‐eluting stents

“…In previous studies, percutaneous balloon angioplasty alone has been associated with high restenosis rates of up to 60% for non aorto‐ostial lesions and 71% for aorto‐ostial lesions [1]. The advent of BMS was associated with a reduction of angiographic restenosis to rates of between 19–50% [9, 14–16], and the need for repeat revascularization at 1 year varied between 12–19% [5, 9, 17].…”