Ressecções gástricas menores com linfadenectomia modificada em câncer gástrico precoce com linfonodo sentinela negativo

Neto, Guilherme Pinto Bravo; Santos, Elizabeth Gomes dos; Loja, Carlos André Dos Santos; Victer, Felipe Carvalho; Neves, Marcelo Soares; Pinto, Márcia; Carvalho, Carlos Eduardo

doi:10.1590/s0100-69912012000300004

Cited by 5 publications

(3 citation statements)

References 31 publications

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“…From 2008 on, with the introduction of endoscopic ultrasonography in HUCFF-UFRJ, patients with early gastric lesions suggestive of cancer at endoscopy underwent endoscopic ultrasound to confirm the degree of tumor penetration of the gastric wall and evaluation of suspect perigastric nodes. Those with echoendoscopic confirmation of early tumor without perigastric lymphadenopathy were operated and submitted to sentinel nodes research, which, when negative, provided the realization of smaller gastric resections with modified D1 lymphadenectomy, as recommended by the Japanese Society of Gastric Cancer 9,10 . Patients with endoscopic ultrasound doubtful as to the degree of penetration of the tumor and/or suspect perigastric lymph nodes were treated for advanced tumors.…”

Section: Methods Methods Methods Methodsmentioning

confidence: 99%

“…Tumor size is another risk factor for the development of lymph node metastases. The greater the injury, the greater the risk of metastases [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16] . In our series, the incidence of metastasis in tumors larger than 2cm was greater than in tumors smaller than 2cm.…”

Section: T T T T Tmentioning

confidence: 99%

“…Kitagawa 29 . Most of these skip metastases concentrated on lymph node chains 7 and 8, which should therefore be included in the lymphadenectomy of patients with negative sentinel nodes undergoing minor gastric resection with modified D1 lymphadenectomy 10 .…”

Section: T T T T Tmentioning

confidence: 99%

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Lymph node metastasis in early gastric cancer

Neto

Santos

Victer

et al. 2014

Rev. Col. Bras. Cir.

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the incidence of lymph node metastases in patients was very high and suggests that one should keep the radicality of resection in early gastric cancer, particularly in relation to D2 lymphadenectomy, recommended for advanced gastric cancer. Conservative resections, with lymphadenectomies smaller than D2, should be performed only in selected cases, well-studied as for the risk factors of lymph node metastasis. Despite the small number of cases did not permit to relate the rate of lymph node metastasis to the risk factors considered, we noted a strong tendency for the occurrence of these metastases in the poorly differentiated, type III, larger than 2 cm tumors, and in the Lauren diffuse types.

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Section: Methods Methods Methods Methodsmentioning

confidence: 99%

Section: T T T T Tmentioning

confidence: 99%

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Lymph node metastasis in early gastric cancer

Neto

Santos

Victer

et al. 2014

Rev. Col. Bras. Cir.

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Integrating No.3 lymph nodes and primary tumor radiomics to predict lymph node metastasis in T1-2 gastric cancer

Wang

Fang

et al. 2021

BMC Med Imaging

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Background This study aimed to develope and validate a radiomics nomogram by integrating the quantitative radiomics characteristics of No.3 lymph nodes (LNs) and primary tumors to better predict preoperative lymph node metastasis (LNM) in T1-2 gastric cancer (GC) patients. Methods A total of 159 T1-2 GC patients who had undergone surgery with lymphadenectomy between March 2012 and November 2017 were retrospectively collected and divided into a training cohort (n = 80) and a testing cohort (n = 79). Radiomic features were extracted from both tumor region and No. 3 station LNs based on computed tomography (CT) images per patient. Then, key features were selected using minimum redundancy maximum relevance algorithm and fed into two radiomic signatures, respectively. Meanwhile, the predictive performance of clinical risk factors was studied. Finally, a nomogram was built by merging radiomic signatures and clinical risk factors and evaluated by the area under the receiver operator characteristic curve (AUC) as well as decision curve. Results Two radiomic signatures, reflecting phenotypes of the tumor and LNs respectively, were significantly associated with LN metastasis. A nomogram incorporating two radiomic signatures and CT-reported LN metastasis status showed good discrimination of LN metastasis in both the training cohort (AUC 0.915; 95% confidence interval [CI] 0.832–0.998) and testing cohort (AUC 0.908; 95% CI 0.814–1.000). The decision curve also indicated its potential clinical usefulness. Conclusions The nomogram received favorable predictive accuracy in predicting No.3 LNM in T1-2 GC, and the nomogram showed positive role in predicting LNM in No.4 LNs. The nomogram may be used to predict LNM in T1-2 GC and could assist the choice of therapy.

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Development and Validation a Nomogram for Predicting the Third Station Lymph Node Metastasis in Early Gastric Cancer

Wang

Liu

Fang

et al. 2021

Preprint

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Background:This study aimed to evaluate the value of radiomic nomogram in predicting lymph node metastasis in T1-2 gastric cancer according to the No. 3 station lymph nodes.Methods:A total of 159 T1-2 gastric cancer (GC) patients who had undergone surgery with lymphadenectomy between March 2012 and November 2017 were retrospectively collected and divided into a primary cohort (n = 80) and a validation cohort (n = 79). Radiomic features were extracted from both tumor region and No. 3 station lymph nodes (LN) based on computed tomography (CT) images per patient. Then, key features were selected using minimum redundancy maximum relevance algorithm and fed into two radiomic signatures, respectively. Meanwhile, the predictive performance of clinical risk factors was studied. Finally, a nomogram was built by merging radiomic signatures and clinical risk factors and evaluated by the area under the receiver operator characteristic curve (AUC) as well as decision curve.Results: Two radiomic signatures, reflecting phenotypes of the tumor and LN respectively, were significantly associated with LN metastasis. A nomogram incorporating two radiomic signatures and CT-reported LN metastasis status showed good discrimination of LN metastasis in both the primary cohort (AUC: 0.915; 95% confidence interval [CI]: 0.832-0.998) and validation cohort (AUC: 0.908; 95%CI: 0.814-1.000). The decision curve also indicated its potential clinical usefulness.Conclusions:The nomogram received favorable predictive accuracy in predicting No.3 station LN metastasis in T1-2 GC, and could assist the choice of therapy.

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Ressecções gástricas menores com linfadenectomia modificada em câncer gástrico precoce com linfonodo sentinela negativo

Cited by 5 publications

References 31 publications

Lymph node metastasis in early gastric cancer

Lymph node metastasis in early gastric cancer

Integrating No.3 lymph nodes and primary tumor radiomics to predict lymph node metastasis in T1-2 gastric cancer

Development and Validation a Nomogram for Predicting the Third Station Lymph Node Metastasis in Early Gastric Cancer

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