Responsiveness to Vasoactive Agents of Cerebral and Mesenteric Arteries Isolated From Control and Reserpine‐treated Dogs

Hayashi, Shigehiro; Miyazaki, Mizuo; Toda, Noboru

doi:10.1111/j.1476-5381.1980.tb14561.x

Cited by 12 publications

(2 citation statements)

References 19 publications

(20 reference statements)

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“…In addition, vascular responses to nicotine are abolished by bretylium or guanethidine (22,23) and pretreatment of animals with reserpine (24), and nicotine increases the 3H-overflow from isolated, superfused vasculature previously soaked in 3H-norepinephrine, as does electrical nerve stimulation (22). These findings strongly suggest that norepinephrine liberated from adrenergic nerves in the penile artery, corpus and penile vein in response to nicotine stimulates aladrenoceptors and elicits contraction.…”

Section: Histological Studymentioning

confidence: 99%

Comparison of Neurogenic Contraction and Relaxation in Canine Corpus Cavernosum and Penile Artery and Vein

Hayashida¹,

Fujimoto

Yoshida³

et al. 1996

Japanese Journal of Pharmacology

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ABSTRACT-Functional roles of autonomic efferent nerves were compared in the isolated canine corpus cavernosum, penile artery and penile vein that participate in the penile erection by changing blood distribution. Nicotine produced moderate contraction in the arterial strips, but only a slight or no contraction in the corpus and venous strips. The contraction was suppressed or reversed to a relaxation by prazosin. Under a,-adrenoceptor blockade, relaxations induced by nicotine were in the order of the corpus > artery >> vein. The response was abolished by 1V~-nitro-L-arginine (L-NA) and restored by L-arginine. The responses to nicotine and exogenous nitric oxide (NO) were abolished by oxyhemoglobin. The relaxant response to transmural electrical stimulation at 5 Hz was greater in the corpus than venous strips treated with prazosin, and it was abolished by L-NA. Contractions caused by nicotine under treatment with L-NA were greater in the artery than in the vein and corpus. Histochemical studies demonstrated nerve fibers containing NO synthase and tyrosine hydroxylase immunoreactivity in the corpus cavernosum, artery and vein. It is concluded that the canine corpus cavernosum, penile artery and penile vein are innervated by adrenergic, vasoconstrictor and nitroxidergic, vasodilator nerves; neurogenic vasodilatation is predominant in the corpus muscle, whereas neurogenic vasoconstriction predominates in the artery. Such a different functioning of the nerves may be responsible for the penile erection.

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Section: Histological Studymentioning

confidence: 99%

Comparison of Neurogenic Contraction and Relaxation in Canine Corpus Cavernosum and Penile Artery and Vein

Hayashida¹,

Fujimoto

Yoshida³

et al. 1996

Japanese Journal of Pharmacology

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“…Thirteen dogs were pretreated 20 to 24 hr before the start of experiments with intramuscular injections of 0.5 mg/kg reserpine; norepinephrine con tents in mesenteric and cerebral arteries are diminished by this pretreatment (12). The heart was removed.…”

Section: Methodsmentioning

confidence: 99%

Responses of isolated dog coronary arteries to tyramine.

Hayashi

Toda

1982

Jpn.J.Pharmacol

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Abstract-In isolated dog coronary arteries contracted with prostaglandin F20, tyramine in concentrations of 10-6 and 5 x 10-6 M caused relaxations, but it produced contractions at 2x10-5 M or higher. The relaxant response to tyramine was attenuated, but the contractile response was enhanced at the second trial as compared with the responses at the first. Relaxations induced by low concentrations of tyramine were reversed to contractions by treatment with propranolol (10-6 M) or sotalol (10-5 M), and were abolished by cocaine (3 x 10-6 M) or bretylium (2x10-5 M). In coronary arteries isolated from reserpine (0.5 mg/kg)-pretreated dogs, tyramine produced only a contraction. Under resting conditions, contractions induced by tyramine (5x10-6 to 2x10-3 M) were potentiated by cocaine and propranolol, and were inhibited by phentolamine. Norepinephrine produced a dose-dependent relaxation in the arteries contracted with prostaglandin Fem. In the presence of propranolol, the arteries under resting conditions were contracted by norepinephrine, the contraction being suppressed by treatment with phentolamine.It may be concluded that relaxations of dog coronary arteries induced by tyramine are mediated by liberation of norepinephrine from adrenergic nerves which stimulates beta adrenoceptors in the smooth muscle. It seems likely that the tyramine (2x10-5 M or higher) -induced contraction is not mediated by norepin ephrine released, but it is partly due to a direct action on alpha-adrenoceptors.

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Rauwolfia Alkaloids (Reserpine)

Howes¹,

Louis²

1990

Pharmacology of Antihypertensive Therapeutics

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Responsiveness to Vasoactive Agents of Cerebral and Mesenteric Arteries Isolated From Control and Reserpine‐treated Dogs

Cited by 12 publications

References 19 publications

Comparison of Neurogenic Contraction and Relaxation in Canine Corpus Cavernosum and Penile Artery and Vein

Comparison of Neurogenic Contraction and Relaxation in Canine Corpus Cavernosum and Penile Artery and Vein

Responses of isolated dog coronary arteries to tyramine.

Rauwolfia Alkaloids (Reserpine)

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