Responsiveness to methamphetamine in adulthood is altered by prenatal exposure in rats

Schutová, Barbora; Hrubá, Lenka; Pometlová, Marie; Rokyta, Richard; Šlamberová, Romana

doi:10.1016/j.physbeh.2009.12.004

Cited by 32 publications

(26 citation statements)

References 50 publications

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“…In the Laboras test, the data showing no effect of prenatal MA exposure on behaviour in male or female rats is in agreement with our previous study examining adult rats prenatally exposed to MA in the open field test (Schutová et al, 2010;Hrubá et al, 2012). Unlike other studies (Heyser et al, 1992;Gagin et al, 1997;Rocha et al, 2002;Estelles et al, 2006) our data did not show any sensitization effect of prenatal MA exposure, except of exploratory activity.…”

Section: Discussionsupporting

confidence: 92%

Effect of Amphetamine on Adult Male and Female Rats Prenatally Exposed to Methamphetamine

et al. 2014

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Abstract:The aim of the present study was to examine the cross-sensitization induced by prenatal methamphetamine (MA) exposure to adult amphetamine (AMP) treatment in male and female rats. Rat mothers received a daily injection of MA (5 mg/kg) or saline throughout the gestation period. Adult male and female offspring (prenatally MA-or saline-exposed) were administered with AMP (5 mg/kg) or saline (1 ml/kg) in adulthood. Behaviour in unknown environment was examined in open field test (Laboras), active drug-seeking behaviour in conditioned place preference test (CPP), spatial memory in the Morris water maze (MWM), and levels of corticosterone (CORT) were analyzed by enzyme immunoassay (EIA). Our data demonstrate that in Laboras test, AMP treatment in adulthood increased general locomotion (time and distance travelled) regardless of the prenatal exposure and sex, while AMP increased exploratory activity (rearing) only in prenatally MA-exposed animals. AMP induced sensitization only in male rats, but not in females when tested drug-seeking behaviour in the CPP test. In the spatial memory MWM test, AMP worsened the performance only in Prague Medical Report / Vol. 115 (2014) No. 1-2, p. 43-59 females, but not in males. On the other hand, males swam faster after chronic AMP treatment regardless of the prenatal drug exposure. EIA analysis of CORT levels demonstrated higher level in females in all measurement settings. In males, prenatal MA exposure and chronic adult AMP treatment decreased CORT levels. Thus, our data demonstrated that adult AMP treatment affects behaviour of adult rats, their spatial memory and stress response in sex-specific manner. The effect is also influenced by prenatal drug exposure. 44)

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Section: Discussionsupporting

confidence: 92%

Effect of Amphetamine on Adult Male and Female Rats Prenatally Exposed to Methamphetamine

et al. 2014

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“…In the EPM test, acute and chronic exposure to psychostimulants has been shown to have both anxiogenic [4,15,17,24,39] as well as anxiolytic effects [13,54]. In the SIT, psychostimulant drugs usually displayed anxiogenic effect in the form of decreased social interaction (SI) indicating increased anxiety [11,19,36,66], which was also observed in our previous studies [62,63] showing that MA administration impairs SI in dose-, stress condition-, and sexspecific manners.…”

Section: Introductionsupporting

confidence: 54%

“…one of the most commonly abused drugs among women, even during pregnancy [32]. Previous studies [1,53,54,64,70] demonstrated that prenatal MA (5 mg/kg) exposure changes behaviour in animals and reduces adaptability to new environments in adulthood. In addition, it has been shown that prenatal MA exposure increases sensitivity to the same drug in adulthood [53,54].…”

Section: Introductionmentioning

confidence: 99%

“…Previous studies [1,53,54,64,70] demonstrated that prenatal MA (5 mg/kg) exposure changes behaviour in animals and reduces adaptability to new environments in adulthood. In addition, it has been shown that prenatal MA exposure increases sensitivity to the same drug in adulthood [53,54]. Specifically, prenatally MA-exposed animals that received challenge doses of MA in adulthood displayed higher locomotion and exploratory rearing activity relative to control animals; this was found to correspond with dopamine levels in the nucleus accumbens [8].…”

Section: Introductionmentioning

confidence: 99%

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Do the effects of prenatal exposure and acute treatment of methamphetamine on anxiety vary depending on the animal model used?

Šlamberová

Pometlová

Macúchová

et al. 2015

Behavioural Brain Research

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“…On the contrary, the corresponding values of IC 50 appeared to be increased in the striatum of previously sensitized rats, which supports the presence of different roles of mesolimbic and nigrostriatal dopaminergic pathways in drug abuse [16]. Our previous studies demonstrated that prenatal MA exposure sensitizes rats to the effect of MA in adulthood and that the increase in behavioural sensitivity was manifested differently in males and females [17][18][19]. In addition, the acute injection of MA in adulthood increased DA levels in the nucleus accumbens more markedly in prenatally exposed rats when compared to prenatally saline-exposed controls [20].…”

Section: Introductionmentioning

confidence: 56%

Sex-Dependent Changes in Striatal Dopamine Transport in Preadolescent Rats Exposed Prenatally and/or Postnatally to Methamphetamine

et al. 2016

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Methamphetamine (MA) is the most commonly used psychostimulant drug, the chronic abuse of which leads to neurodegenerative changes in the brain. The global use of MA is increasing, including in pregnant women. Since MA can cross both placental and haematoencephalic barriers and is also present in maternal milk, children of chronically abused mothers are exposed prenatally as well as postnatally. Women seem to be more vulnerable to some aspects of MA abuse than men. MA is thought to exert its effects among others via direct interactions with dopamine transporters (DATs) in the brain tissue. Sexual dimorphism of the DAT system could be a base of sex-dependent actions of MA observed in behavioural and neurochemical studies. Possible sex differences in the DATs of preadolescent offspring exposed to MA prenatally and/or postnatally have not yet been evaluated. We examined the striatal synaptosomal DATs (the activity and density of surface expressed DATs and total DAT expression) in preadolescent male and female Wistar rats (31-35-day old animals) exposed prenatally and/or postnatally to MA (daily 5 mg/kg, s.c. to mothers during pregnancy and lactation). To distinguish between specific and nonspecific effects of MA on DATs, we also evaluated the in vitro effects of lipophilic MA on the fluidity of striatal membranes isolated from preadolescent and young adult rats of both sexes. We observed similar changes in the DATs of preadolescent rats exposed prenatally or postnatally (MA-mediated drop in the reserve pool but no alterations in surface-expressed DATs). However, prenatal exposure evoked significant changes in males and postnatal exposure in females. A significant decrease in the activity of surface-expressed DATs was found only in postnatally exposed females sensitized to MA via prenatal exposure. MA applied in vitro increased the fluidity of striatal membranes of preadolescent female but not male rats. In summary, DATs of preadolescent males are more sensitive to prenatal MA exposure via changes in the reserve pool and those of preadolescent females to postnatal MA exposure via the same mechanism. The combination of prenatal and postnatal MA exposure increases the risk of dopaminergic deficits via alterations in the activity of surface-expressed DATs especially in preadolescent females. MA-mediated changes in DATs of preadolescent females could be still enhanced via nonspecific disordering actions of MA on striatal membranes.

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Responsiveness to methamphetamine in adulthood is altered by prenatal exposure in rats

Cited by 32 publications

References 50 publications

Effect of Amphetamine on Adult Male and Female Rats Prenatally Exposed to Methamphetamine

Effect of Amphetamine on Adult Male and Female Rats Prenatally Exposed to Methamphetamine

Do the effects of prenatal exposure and acute treatment of methamphetamine on anxiety vary depending on the animal model used?

Sex-Dependent Changes in Striatal Dopamine Transport in Preadolescent Rats Exposed Prenatally and/or Postnatally to Methamphetamine

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