Responsiveness to estradiol in central nervous system of aging female rats

Dudley, Susan D.

doi:10.1016/0149-7634(82)90005-7

Cited by 27 publications

(14 citation statements)

References 46 publications

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“…Generally, rats maintain their regular estrous cycles from 9 to 12 months of age, which is then followed by prolonged pseudopregnancy, or anestrous states, with concurrent alterations in endocrine function (Dudley 1982). Rats of 11 months of age were chosen for the study, and their estrous cycles were examined 2 weeks before treatment.…”

Section: Discussionmentioning

confidence: 99%

Effects of plant polyphenols on ovarian follicular reserve in aging ratsThis paper is one of a selection of papers published in this special issue entitled “Second International Symposium on Recent Advances in Basic, Clinical, and Social Medicine” and has undergone the Journal's usual peer review process.

Chen

Luo

et al. 2010

Biochem. Cell Biol.

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The pool of ovarian primordial follicles is established during embryonic development or at birth. During the development from primordial to primary, secondary, and antral follicles, only a small portion of follicles can mature and successfully ovulate; the others are destined to degenerate through apoptotic or atretic loss. As aging advances, females ultimately enter the cessation phase of the estrous cycle and are no longer capable of fertilization. The presumption is that if we can slow down the process of folliculogenesis or decrease follicle loss, females may have a larger ovarian follicular reserve and a longer reproductive lifespan. In our study, rats underwent intragastric administration with tea polyphenols, quercetin (meletin), genistein, or resveratrol, once a day for 4 months (from age 12 to 15 months), to test whether they have positive effects on follicular reserve or ovarian functions. The results showed that rats treated with tea polyphenols (27.8 +/- 3.2) and quercetin (36.5 +/- 4.1) had a comparable number of healthy follicles to those of controls (26.9 +/- 3.8), although significantly fewer atretic follicles were observed in the tea polyphenol group (43.4 +/- 5.9 vs 79.7 +/- 7.5; p < 0.001). Remarkably, both genistein- and resveratrol-treated rats had more healthy follicles (respectively, 42.8 +/- 3.9, p < 0.05; and 51.9 +/- 6.4, p < 0.001) and fewer atretic follicles (respectively, 58.4 +/- 8.0, p < 0.05; and 51.0 +/- 6.2, p < 0.01) than controls. These results indicate that genistein and resveratrol can increase the ovarian follicular reserve and prolong the ovarian lifespan in rats, and their positive effects may be not only due to their intervention in the transition from primordial to primary follicle, but also due to the inhibiting effect on follicular atresia.

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Section: Discussionmentioning

confidence: 99%

Effects of plant polyphenols on ovarian follicular reserve in aging ratsThis paper is one of a selection of papers published in this special issue entitled “Second International Symposium on Recent Advances in Basic, Clinical, and Social Medicine” and has undergone the Journal's usual peer review process.

Chen

Luo

et al. 2010

Biochem. Cell Biol.

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“…Prior to sacrifice, females underwent daily vaginal lavage in order to determine their estrous or estropausal status (as described in Markham & Juraska, 2002). Unlike menopausal women, estropausal rats continue to secrete moderate levels of ovarian hormones in one of two estropausal states (Dudley, 1982;Markham & Juraska, 2002). The middle and old age females had to remain in their estropausal state for 10 days to determine their classification.…”

Section: Methodsmentioning

confidence: 99%

Increases in size and myelination of the rat corpus callosum during adulthood are maintained into old age

Yates

Juraska

2007

Brain Research

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Although there are indications of growth in the size and myelination of the rat corpus callosum during adulthood, it is not known how long this growth continues. In addition, the potential for age-related changes in these measures to affect the sex differences seen in adulthood has not been examined. Here the size of callosal subregions and area occupied by myelin were examined in the genu and splenium of male and female rats in adulthood, middle-age, and old age. Our findings revealed increases both in size and in the area composed of myelin between adulthood and middle-age that were maintained into old age, with no indications of age-related loss in either the genu or splenium of the rat.

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“…We found that despite ovx and E 2 -replacement and aging (which can be associated with changes in response to E 2 [22] . Although these data were intriguing and suggest that there may be persistent effects of E 2 exposure/parity for these measures, it was not possible to compare these effects in age-matched nulliparous rats.…”

Section: Introductionmentioning

confidence: 94%

Parity and estrogen-administration alter affective behavior of ovariectomized rats

Walf

Frye

2008

Physiology & Behavior

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Evidence from clinical and basic research studies demonstrates that estradiol (E 2 ) reduces anxiety and/or depressive behavior; however, this effect is not observed in all studies. One factor that may mitigate differential responses to E 2 may be previous E 2 experience, i.e. parity. To investigate this, performance in tasks that are utilized to assess whether compounds, such as E 2 , can alter anxietylike behavior (elevated plus maze) and have anti-depressant-like effects (forced swim test) were determined. Performance of ovariectomized (ovx), young (3-6 months old) rats that had never had a litter (nulliparous) was compared to that of those that had several litters in their lifetime (multiparous) following 48 h of oil vehicle or E 2 (10 µg) administration. We predicted that E 2 would decrease anxiety-like behavior and increase anti-depressant-like effects of ovx rats and that this pattern may be influenced by parity. Multiparous rats, irrespective of E 2 -priming, had increased open arm time compared to nulliparous rats. Administration of E 2 to ovx, nulliparous or multiparous rats decreased immobility in the forced swim test compared to vehicle-administration. Together, these data suggest that E 2 can alter affective behavior and rats with greater reproductive experience have decreased anxiety-like behavior in the elevated plus maze, irrespective of E 2 -priming.

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Responsiveness to estradiol in central nervous system of aging female rats

Cited by 27 publications

References 46 publications

Increases in size and myelination of the rat corpus callosum during adulthood are maintained into old age

Parity and estrogen-administration alter affective behavior of ovariectomized rats

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