Responsiveness of swine divergently selected for feed efficiency to exogenous adrenocorticotropic hormone and glucose challenges

Colpoys, Jessica D.; Sambeek, Dana van; Bruns, Christina; Johnson, Anna K.; Dekkers, Jack C. M.; Dunshea, Frank R.; Gabler, Nicholas K.

doi:10.1016/j.domaniend.2018.12.007

Cited by 4 publications

(2 citation statements)

References 45 publications

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“…In agreement, it was well documented that pigs with high feed efficiency showed lower susceptibility to oxidative stress during production compared to pigs with low feed efficiency, resulting in lower inflammatory responses and lower growth impairment [26]. Moreover, a previous study in pigs indicated that genetic selection for low RFI (high feed efficiency) resulted in less stress responsiveness [27]. We further analyzed the KEGG pathways of DEGs, including 8 significantly enriched pathways.…”

Section: Functional Annotation and Biological Interpretation Of Degssupporting

confidence: 74%

Identification of key genes and pathways associated with feed efficiency of native chickens based on transcriptome data via bioinformatics analysis

Yang

Xiong

et al. 2020

BMC Genomics

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Background: Improving feed efficiency is one of the important breeding targets for poultry industry. The aim of current study was to investigate the breast muscle transcriptome data of native chickens divergent for feed efficiency. Residual feed intake (RFI) value was calculated for 1008 closely related chickens. The 5 most efficient (LRFI) and 5 least efficient (HRFI) birds were selected for further analysis. Transcriptomic data were generated from breast muscle collected post-slaughter. Results: The differently expressed genes (DEGs) analysis showed that 24 and 325 known genes were significantly up-and down-regulated in LRFI birds. An enrichment analysis of DEGs showed that the genes and pathways related to inflammatory response and immune response were up-regulated in HRFI chickens. Moreover, Gene Set Enrichment Analysis (GSEA) was also employed, which indicated that LRFI chickens increased expression of genes related to mitochondrial function. Furthermore, protein network interaction and function analyses revealed ND2, ND4, CYTB, RAC2, VCAM1, CTSS and TLR4 were key genes for feed efficiency. And the 'phagosome', 'cell adhesion molecules (CAMs)', 'citrate cycle (TCA cycle)' and 'oxidative phosphorylation' were key pathways contributing to the difference in feed efficiency. Conclusions: In summary, a series of key genes and pathways were identified via bioinformatics analysis. These key genes may influence feed efficiency through deep involvement in ROS production and inflammatory response. Our results suggested that LRFI chickens may synthesize ATP more efficiently and control reactive oxygen species (ROS) production more strictly by enhancing the mitochondrial function in skeletal muscle compared with HRFI chickens. These findings provide some clues for understanding the molecular mechanism of feed efficiency in birds and will be a useful reference data for native chicken breeding.

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Section: Functional Annotation and Biological Interpretation Of Degssupporting

confidence: 74%

Identification of key genes and pathways associated with feed efficiency of native chickens based on transcriptome data via bioinformatics analysis

Yang

Xiong

et al. 2020

BMC Genomics

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“…Therefore, apart from a domestication process based on selection on tameness/docility, differences in HPA axis activity and cortisol production were likely driven further by breeding for greater lean deposition as indicated for example by the observation that breeds showing greater adiposity, e.g., Chinese breeds, typically feature greater cortisol concentrations compared with elite commercial breeds [ 84 , 90 , 91 ]. However, while cortisol production is linked with a wide range of production traits (i.e., feed efficiency [ 92 ], piglet survival [ 93 , 94 ]), this relationship is quite complex and often ambiguous [ 95 , 96 ]. This exemplifies the limited explanatory power of individual endocrine biomarkers and hence requirement for a holistic approach integrating other parts of the signalling cascade.…”

Section: Genetics Of Stress Responsementioning

confidence: 99%

Omics Application in Animal Science—A Special Emphasis on Stress Response and Damaging Behaviour in Pigs

Kasper

Ribeiro

Almeida

et al. 2020

Genes

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Increasing stress resilience of livestock is important for ethical and profitable meat and dairy production. Susceptibility to stress can entail damaging behaviours, a common problem in pig production. Breeding animals with increased stress resilience is difficult for various reasons. First, studies on neuroendocrine and behavioural stress responses in farm animals are scarce, as it is difficult to record adequate phenotypes under field conditions. Second, damaging behaviours and stress susceptibility are complex traits, and their biology is not yet well understood. Dissecting complex traits into biologically better defined, heritable and easily measurable proxy traits and developing biomarkers will facilitate recording these traits in large numbers. High-throughput molecular technologies (“omics”) study the entirety of molecules and their interactions in a single analysis step. They can help to decipher the contributions of different physiological systems and identify candidate molecules that are representative of different physiological pathways. Here, we provide a general overview of different omics approaches and we give examples of how these techniques could be applied to discover biomarkers. We discuss the genetic dissection of the stress response by different omics techniques and we provide examples and outline potential applications of omics tools to understand and prevent outbreaks of damaging behaviours.

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Comparative analysis of signalling pathways in tissue protein metabolism in efficient and non-efficient beef cattle: acute response to an identical single meal size

Guarnido-Lopez,

Ortigues-Marty,

David

et al. 2023

animal

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Responsiveness of swine divergently selected for feed efficiency to exogenous adrenocorticotropic hormone and glucose challenges

Cited by 4 publications

References 45 publications

Identification of key genes and pathways associated with feed efficiency of native chickens based on transcriptome data via bioinformatics analysis

Identification of key genes and pathways associated with feed efficiency of native chickens based on transcriptome data via bioinformatics analysis

Omics Application in Animal Science—A Special Emphasis on Stress Response and Damaging Behaviour in Pigs

Comparative analysis of signalling pathways in tissue protein metabolism in efficient and non-efficient beef cattle: acute response to an identical single meal size

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