Responsiveness of plasma aldosterone to angiotensin II in patients with diabetes mellitus.

Morimoto, Shinji; Uchida, Keiji; Kigoshi, Toshikazu; Hosojima, Hiroyuki; Yamamoto, Ikuo; Azukizawa, Sadahide

doi:10.1507/endocrj1954.30.671

Cited by 8 publications

(2 citation statements)

References 29 publications

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“…The atrial natriuretic factor (ANF) is synthe-sized in the atria and stored in membrane-bound granules (2)(3)(4)(5). Because diabetic subjects show abnormalities in fluid and electrolyte balance (6,7) and perturbations in the reninangiotensin-aldosterone system and vasopressin levels (8,9), it could be postulated that in the diabetic condition, the ANF system may also show abnormalities. In addition to fluid, electrolyte, and hormonal alterations, diabetic patients also frequently show evidence of cardiomyopathy (10).…”

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Atrial Structure and Plasma ANF Levels in Rats With Chronic Diabetes Mellitus

Todd

Hebden²,

Gowen³

et al. 1990

Diabetes

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The effect of streptozocin-induced diabetes (STZ-D) on right atrial structure was investigated in male Wistar rats. STZ (55 mg/kg) or saline (1 ml/kg) was administered by intravenous injection 12 wk before the experimental studies. Tissue was sampled from four regions of the atrium, processed, and embedded in plastic. Quantitative stereological analysis indicated that in STZ-D rats, there was a significant diminution in size of the musculi pectinati (muscular ridges), which form a network making up the wall of the atrium. In addition, within the muscular ridges, there was a significant reduction in the relative proportion of cardiocytes within the cardiac tissue. The rest of the cardiac tissue consisted of interstitial regions, connective tissue, and blood vessels, which correspondingly increased. This suggests there was some form of cardiomyopathy. When atrial granularity was determined relative to cardiocyte volume density, a significant decrease (54%) was found in tissue from STZ-D rats. The blood pressure of conscious STZ-D rats was significantly lower than control rats, whereas right atrial pressure was not different. The level of resting plasma immunoreactive atrial natriuretic factor (ANF) in conscious STZ-D rats (98 +/- 5 pg/ml) was significantly higher than in control rats (52 +/- 7 pg/ml). The decreased atrial granularity could be related to the higher resting plasma ANF levels, suggesting a more rapid turnover or increased synthesis bypassing storage in the granular form.

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confidence: 99%

Atrial Structure and Plasma ANF Levels in Rats With Chronic Diabetes Mellitus

Todd

Hebden²,

Gowen³

et al. 1990

Diabetes

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“…have been observed in decompensated diabetes mellitus (1)(2)(3). Changes in the renin-angiotensinaldosterone system and vasopressin secretion have been shown both in patients with diabetes mellitus (4,5), and in rats treated with the diabetogenic agent, streptozotocin (STZ) (6)(7)(8). Atrial natriuretic hormone (ANH) is a hormone released by atrial myocytes in response to acute (9) and chronic (10) extracellular volume expansion.…”

Section: Disturbances Of Water and Electrolyte Metabolismmentioning

confidence: 99%

Effect of diabetes mellitus on levels of atrial natriuretic hormone in plasma and the right atrium in the non-obese diabetic mouse

Yano

Tanigawa²,

Suzuki³

et al. 1991

Acta Endocrinologica

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Abstract. Atrial natriuretic hormone (ANH) levels in plasma and the right atrium of non-bose diabetic mice in the decompensated diabetic state were investigated by radioimmunoassay and histological examination. Severely diabetic mice, with blood glucose levels over 33.6 mmol/l showed significantly higher hematocrit, plasma sodium and calculated plasma osmolarity than the age-matched normoglycemic mice. The plasma ANH levels in diabetic mice were significantly lower (17.5 pmol/l than those in normoglycemic mice (43.6 pmol/l). The ANH concentrations in the right atrium were 26.6 mg/g protein in the diabetic and 11.2 mg/g protein in the normoglycemic mice. The right atrium in the diabetic mice showed much wider immunohistochemical staining by anti-human ANH antiserum compared with the normoglycemic mice. An increase in the number of atrial specific granules in the diabetic mice was observed by transmission and scanning electron microscopy. Morphometrical analysis indicated that the number of granules increased to more than twice that in the normoglycemic mice. These findings indicate that plasma ANH decreases in diabetic mice. The store of right atrial ANH may be increased to compensate for the marked dehydration in severe diabetes.

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