Responsiveness of EORTC QLQ-C30, QLQ-CR38 and FACT-C quality of life questionnaires in patients with colorectal cancer

Abstract

BackgroundThe aim of this study was to compare the responsiveness of the European Organization for Research and Treatment (EORTC) quality of life questionnaires (QLQ-C30, QLQ-CR38) and the Functional Assessment of Cancer Therapy-colorectal version 4 questionnaire (FACT-C).MethodThis prospective study included 127 patients with colorectal cancer: 71 undergoing chemotherapy and 56 radiation therapy. Responsiveness statistics included the Standardized Response Mean (SRM) and the Effect Size (ES). The patient's overall assessment of his/her change in state of health status was the reference criterion to evaluate the responsiveness of the QoL questionnaires.Results34 patients perceived their health as stable and 17 as improved between the first and the fourth courses of chemotherapy. 21 patients perceived their health as stable and 22 as improved between before and the last week of radiotherapy.The responsiveness of the 3 questionnaires differed according to treatments. The EORTC QLQ-C30 questionnaire was more responsive in patients receiving chemotherapy, particulary functional scales (SRM > 0.55). The QLQ-CR38 and the FACT-C questionnaires provided little clinically relevant information during chemotherapy or radiotherapy.ConclusionThe EORTC QLQ-C30 questionnaire appears to be more responsive in patients receiving chemotherapy.

Psychometric Validation of the Malaysian Chinese Version of the EORTC QLQ-C30 in Colorectal Cancer Patients

“…This questionnaire is frequently used in cancer of the colorectum (Hung et al, 2013;Smith et al, 2013). The questionnaire has been validated across many cultures and disease conditions and was found to have adequate acceptable psychometric properties (Schwenk et al, 2004;Huang et al, 2007;Jayasekara et al, 2008;Luckett et al, 2011;Uwer et al, 2011;Yakar and Pinar, 2013). Details of its application, interpretation and reference values for comparison among different groups of patients are readily available (King, 1996;Michelson et al, 2000;Fayers, 2001;Arraras Urdaniz et al, 2008;Finck et al, 2012).…”

Health-related quality of life and cost comparison of adjuvant capecitabine versus 5-fluorouracil/leucovorin in stage III colorectal cancer patients

“…These instruments have been previously validated for measuring cancer patient HRQoL in various multicultural clinical research settings [20][21][22][23]. Patients in both groups completed baseline data, self-administered QLQ-C30 and QLQ-CR38 questionnaires prior to adjuvant chemotherapy (baseline: week 0), during chemotherapy (week 12) and postchemotherapy (week 28).…”

The effect of hypnotherapy on the quality of life in women with breast cancer

“…The EORTC QLQ-C30 consists of 30 items, 24 of which are organized into 9 multi-item scales that represent various dimensions of quality of life: an overall scale; 5 functioning scales (physical, role, emotional, cognitive, and social); and 3 scales to measure symptoms (fatigue, pain, and nausea) (Aaronson et al, 1993). The EORTC QLQ-C30 is considered to be highly sensitive in detecting changes in well-being in cancer patients during chemotherapy (Uwer et al, 2011).…”