Responsiveness and minimal clinically important difference for the EQ-5D in chronic rhinosinusitis

Hoehle, Lloyd P.; Phillips, Katie; Speth, Marlene M.; Caradonna, David S.; Gray, Sarah; Sedaghat, Ahmad R.

doi:10.4193/rhin18.122

Cited by 32 publications

(71 citation statements)

References 33 publications

(61 reference statements)

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“…This study also had several limitations. Apart from the GRCQ, a disease-specific questionnaire was a commonly used anchor in previous studies [ 25 , 38 ]; however, we did not use a disease-specific questionnaire for CIN such as the Functional Assessment of Chronic Illness Therapy–Cervical Dysplasia, since there is no Chinese version [ 57 ]. Although the GRCQ has only one question, it is the accepted anchor for MCID estimation at this stage [ 17 ].…”

Section: Discussionmentioning

confidence: 99%

“…The anchor-based method used the GRCQ as an external anchor and regarded the transition rating corresponding to “a little” changes as the MCID. Since no patient responded to the anchor question as “worse” in this study, the MCID estimate was performed only for the transition rating “better.” Therefore, the MCID was defined as the difference of the mean change scores of the EQ-5D-5L between the transition ratings of GRCQ that were “a little better” and “about the same” [ 38 , 39 ].…”

Section: Methodsmentioning

confidence: 99%

“…Since no patient responded to the anchor question as "worse" in this study, the MCID estimate was performed only for the transition rating "better. " Therefore, the MCID was defined as the difference of the mean change scores of the EQ-5D-5L between the transition ratings of GRCQ that were "a little better" and "about the same" [38,39].…”

Section: Minimal Clinically Important Differencementioning

confidence: 99%

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Responsiveness and minimal clinically important difference of the EQ-5D-5L in cervical intraepithelial neoplasia: a longitudinal study

Jing

Zhang

et al. 2020

Health Qual Life Outcomes

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Background With the widespread clinical application of the five-level version of the EuroQol five-dimensional questionnaire (EQ-5D-5L), whether the questionnaire scores are responsive to changes in patients’ health and how much changes in questionnaire scores represent patients’ real health changes require consideration. Consequently, we assessed responsiveness and estimated the minimal clinically important difference (MCID) of the EQ-5D-5L in surgically treated patients with cervical intraepithelial neoplasia (CIN) to determine the relationship between MCID and minimal detectable change (MDC). Methods We conducted a longitudinal, observational study. Participants were patients with CIN from the gynecology inpatient department of a grade-A tertiary hospital in Shihezi, Xinjiang, China. Participants completed the EQ-5D-5L and the Global Rating of Change Questionnaire (GRCQ) at baseline and one month post-surgery. The Wilcoxon signed-rank test was used to compare EQ-5D-5L scores pre- and post-treatment. We calculated the effect size (ES) and the standardized response mean (SRM) to quantitatively assess responsiveness. Distribution-based, anchor-based, and instrument-defined methods were used to estimate MCID. MCID to MDC ratios at individual- and group-levels were also calculated. Results Fifty patients with CIN completed the follow-up investigation (mean age 44.76 ± 8.72 years; mean follow-up time 32.28 ± 1.43 days). The index value and EQ visual analogue scale (EQ VAS) of the EQ-5D-5L improved by 0.025 and 6.92 (all p < 0.05) at follow-up as compared to baseline respectively. The ES and the SRM of the index value were 0.47 and 0.42 respectively, indicating small responsiveness; while the ES and the SRM of EQ VAS were 0.50 and 0.49 respectively, indicating small to moderate responsiveness. The average (range) of MCIDs for index value and EQ VAS were 0.039 (0.023–0.064) and 5.35 (3.12–6.99) respectively. These values can only be used to determine whether patients have experienced clinically meaningful health improvements at the group level. Conclusions The EQ-5D-5L has only small to moderate responsiveness in post-surgical patients with CIN, and the MCIDs developed in this study can be used for group-level health assessment. However, further study is needed concerning health changes at the individual level.

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Minimal Clinically Important Differencementioning

confidence: 99%

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Responsiveness and minimal clinically important difference of the EQ-5D-5L in cervical intraepithelial neoplasia: a longitudinal study

Jing

Zhang

et al. 2020

Health Qual Life Outcomes

View full text Add to dashboard Cite

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“…This study also had several limitations. Apart from the GRCQ, a disease-speci c questionnaire was a commonly used anchor in previous studies [25,38]; however, we did not use a disease-speci c questionnaire for CIN, such as the Functional Assessment of Chronic Illness Therapy-Cervical Dysplasia, since there is no Chinese version [57]. Although the GRCQ has only one question, it is the accepted anchor for MCID estimation at this stage [17].…”

Section: Discussionmentioning

confidence: 99%

“…Since no patient responded to the anchor question as "worse" in this study, the MCID estimate was performed only for the transition rating "better." Therefore, the MCID de ned as the difference of the mean change scores of the EQ-5D-5L between transition rating of GRCQ that were "a little better" and "about the same" [38,39].…”

Section: Statistical Analysesmentioning

confidence: 99%

Responsiveness and minimal clinically important difference of the EQ-5D-5L in cervical intraepithelial neoplasia: a longitudinal study

Jing

Zhang

et al. 2020

Preprint

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Background: With the widespread clinical application of the five-level version of the EuroQol five-dimensional questionnaire (EQ-5D-5L), whether the questionnaire scores are responsive to changes in patients’ health and how much changes in questionnaire scores represent patients’ real health changes require consideration. Consequently, we assessed responsiveness and estimated the minimal clinically important difference (MCID) of the EQ-5D-5L in surgically treated patients with cervical intraepithelial neoplasia (CIN) to determine the relationship between MCID and minimum detectable change (MDC).Methods: This was a longitudinal, observational study. Participants were patients with CIN from the gynecology inpatient department of a grade-A tertiary hospital in Shihezi, Xinjiang, China. Participants completed the EQ-5D-5L and the Global Rating of Change Questionnaire (GRCQ) at baseline and one month post-surgery. The Wilcoxon signed-rank test was used to compare EQ-5D-5L scores pre- and post-treatment. We calculated effect size (ES) and standardized response mean (SRM) to quantitatively assess responsiveness. Distribution-based, anchor-based, and instrument-defined methods were used to estimate MCID. MCID to MDC ratios at individual- and group-levels were also calculated.Results: Fifty patients with CIN completed the follow-up investigation (mean age 44.76 ± 8.72 years; mean follow-up time 32.28 ± 1.43 days). The index value and EQ visual analogue scale (EQ VAS) of the EQ-5D-5L improved by 0.025 and 6.92 (all p < 0.05) at follow-up as compared to baseline, respectively. ES and SRM of the index value were 0.47 and 0.42, respectively, indicating small responsiveness; while ES and SRM of EQ VAS were 0.50 and 0.49, respectively, indicating small to moderate responsiveness. The average (range) of MCIDs for index value and EQ VAS were 0.039 (0.023–0.064) and 5.35 (3.12–6.99), respectively, which can only be used for determining whether patients have experienced clinically meaningful health improvements at the group level. Conclusions: The EQ-5D-5L has only small to moderate responsiveness in post-surgical patients with CIN, and the MCIDs developed in this study can be used for group-level health assessment. However, further study is needed concerning health changes at the individual level. Keywords Responsiveness; MCID; EQ-5D-5L; CIN; MDC

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Effect of Collaborative Telerehabilitation on Functional Impairment and Pain Among Patients With Advanced-Stage Cancer

Cheville

Moynihan

Herrin³

et al. 2019

JAMA Oncol

106

135

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IMPORTANCE Most patients with advanced-stage cancer develop impairment and pain-driven functional losses that jeopardize their independence. OBJECTIVE To determine whether collaborative telerehabilitation and pharmacological pain management improve function, lessen pain, and reduce requirements for inpatient care. DESIGN, SETTING, AND PATIENTS The Collaborative Care to Preserve Performance in Cancer (COPE) study was a 3-arm randomized clinical trial conducted at 3 academic medical centers within 1 health care system. Patient recruitment began in March 2013 and follow-up concluded in October 2016. Participants (N = 516) were low-level community or household ambulators with stage IIIC or IV solid or hematologic cancer. INTERVENTIONS Participants were randomly assigned to the (1) control arm, (2) telerehabilitation arm, or (3) telerehabilitation with pharmacological pain management arm. All patients underwent automated function and pain monitoring with data reporting to their care teams. Participants in arms 2 and 3 received 6 months of centralized telerehabilitation provided by a physical therapist-physician team. Those in arm 3 also received nurse-coordinated pharmacological pain management. MAIN OUTCOMES AND MEASURES Blinded assessment of function using the Activity Measure for Postacute Care computer adaptive test, pain interference and average intensity using the Brief Pain Inventory, and quality of life using the EQ-5D-3L was performed at baseline and months 3 and 6. Hospitalizations and discharges to postacute care facilities were recorded. RESULTS The study included 516 participants (257 women and 259 men; mean [SD] age, 65.6 [11.1] years), with 172 randomized to 1 of 3 arms. Compared with the control group, the telerehabilitation arm 2 had improved function (difference, 1.3; 95% CI, 0.08-2.35; P = .03) and quality of life (difference, 0.04; 95% CI, 0.004-0.071; P = .01), while both telerehabilitation arms 2 and 3 had reduced pain interference (arm 2, −0.

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Responsiveness and minimal clinically important difference for the EQ-5D in chronic rhinosinusitis

Cited by 32 publications

References 33 publications

Responsiveness and minimal clinically important difference of the EQ-5D-5L in cervical intraepithelial neoplasia: a longitudinal study

Responsiveness and minimal clinically important difference of the EQ-5D-5L in cervical intraepithelial neoplasia: a longitudinal study

Responsiveness and minimal clinically important difference of the EQ-5D-5L in cervical intraepithelial neoplasia: a longitudinal study

Effect of Collaborative Telerehabilitation on Functional Impairment and Pain Among Patients With Advanced-Stage Cancer

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