Responsive DNA G-quadruplex micelles

Cozzoli, Liliana; Gjonaj, Lorina; Stuart, Marc C. A.; Poolman, Bert; Roelfes, Gérard

doi:10.1039/c7cc07899d

Cited by 31 publications

(36 citation statements)

References 28 publications

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“…The loading approach based on the virus-like particles is probably to be utilized as a high-impact drug delivery system. Similar to the reported results [28,29], the DNA–lipid assemblies with G-quadruplex structures were stable enough in the presence of the serum albumin and the subsequent cellular uptake was achieved through DNA hybridization, which suggested these biocompatible DNA micelles as nanocarriers for cargo release in vivo applications.…”

Section: Small Molecules Modified Dnasupporting

confidence: 89%

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Amphiphilic DNA Organic Hybrids: Functional Materials in Nanoscience and Potential Application in Biomedicine

Zhao

Liang

et al. 2018

IJMS

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Due to the addressability and programmability, DNA has been applied not merely in constructing static elegant nanostructures such as two dimensional and three dimensional DNA nanostructures but also in designing dynamic nanodevices. Moreover, DNA could combine with hydrophobic organic molecules to be a new amphiphilic building block and then self-assemble into nanomaterials. Of particular note, a recent state-of-the-art research has turned our attention to the amphiphilic DNA organic hybrids including small molecule modified DNA (lipid-DNA, fluorescent molecule-DNA, etc.), DNA block copolymers, and DNA-dendron hybrids. This review focuses mainly on the development of their self-assembly behavior and their potential application in nanomaterial and biomedicine. The potential challenges regarding of the amphiphilic DNA organic hybrids are also briefly discussed, aiming to advance their practical applications in nanoscience and biomedicine.

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Section: Small Molecules Modified Dnasupporting

confidence: 89%

“…With a similar idea, Roelfes and coworkers recently achieved the fabrication DNA–lipid micelles with G-quadruplex structures. The micelles were disaggregated by hybridization with a complementary DNA sequence and lead to cargo release [29]. …”

Section: Small Molecules Modified Dnamentioning

confidence: 99%

Amphiphilic DNA Organic Hybrids: Functional Materials in Nanoscience and Potential Application in Biomedicine

Zhao

Liang

et al. 2018

IJMS

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“…Due to their amphipathic nature, oligonucleotide conjugates with lipophilic groups can self-assemble in aqueous solutions and form micelles [ 10 , 12 , 13 , 14 , 15 , 16 , 17 , 18 ] and their aggregates [ 10 , 11 , 14 ], vesicular assemblies [ 19 , 20 ], and more complex self-aggregation structures [ 2 , 11 , 21 ]. Generally, these structures are nearly spherical in shape [ 10 , 15 , 16 , 20 , 22 , 23 ].…”

Section: Introductionmentioning

confidence: 99%

Amphiphilic “Like-A-Brush” Oligonucleotide Conjugates with Three Dodecyl Chains: Self-Assembly Features of Novel Scaffold Compounds for Nucleic Acids Delivery

et al. 2020

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The conjugation of lipophilic groups to oligonucleotides is a promising approach for improving nucleic acid-based therapeutics’ intracellular delivery. Lipid oligonucleotide conjugates can self-aggregate in aqueous solution, which gains much attention due to the formation of micellar particles suitable for cell endocytosis. Here, we describe self-association features of novel “like-a-brush” oligonucleotide conjugates bearing three dodecyl chains. The self-assembly of the conjugates into 30–170 nm micellar particles with a high tendency to aggregate was shown using dynamic light scattering (DLS), atomic force (AFM), and transmission electron (TEM) microscopies. Fluorescently labeled conjugates demonstrated significant quenching of fluorescence intensity (up to 90%) under micelle formation conditions. The conjugates possess increased binding affinity to serum albumin as compared with free oligonucleotides. The dodecyl oligonucleotide conjugate and its duplex efficiently internalized and accumulated into HepG2 cells’ cytoplasm without any transfection agent. It was shown that the addition of serum albumin or fetal bovine serum to the medium decreased oligonucleotide uptake efficacy (by 22.5–36%) but did not completely inhibit cell penetration. The obtained results allow considering dodecyl-containing oligonucleotides as scaffold compounds for engineering nucleic acid delivery vehicles.

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“…In addition to the regular DNA duplex formation via the Watson–Crick base pairing, DNA strands can bind through other types of sequence‐specific or nonspecific interactions. Such unconventional DNA interactions, which include the intercalated motif (i‐motif) and G‐quadruplex, have been used for the dynamic structural control of DNA nanostructures. i‐motifs are quadruplex structures formed between cytosine‐rich DNA through the protonation of cytosine at an acidic pH and the cytosine‐protonated cytosine (CC + ) base pairing .…”

Section: Dna‐conjugated Organic Molecules and Polymersmentioning

confidence: 99%

Dynamic Nanostructures from DNA‐Coupled Molecules, Polymers, and Nanoparticles

Albert

Park

2019

Small

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Dynamic and reconfigurable systems that can sense and react to physical and chemical signals are ubiquitous in nature and are of great interest in diverse areas of science and technology. DNA is a powerful tool for fabricating such smart materials and devices due to its programmable and responsive molecular recognition properties. For the past couple of decades, DNA‐based self‐assembly is actively explored to fabricate various DNA–organic and DNA–inorganic hybrid nanostructures with high‐precision structural control. Building upon past development, researchers have recently begun to design and assemble dynamic nanostructures that can undergo an on‐demand transformation in the structure, properties, and motion in response to various external stimuli. In this Review, recent advances in dynamic DNA nanostructures, focusing on hybrid structures fabricated from DNA‐conjugated molecules, polymers, and nanoparticles, are introduced, and their potential applications and future perspectives are discussed.

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Responsive DNA G-quadruplex micelles

Cited by 31 publications

References 28 publications

Amphiphilic DNA Organic Hybrids: Functional Materials in Nanoscience and Potential Application in Biomedicine

Amphiphilic DNA Organic Hybrids: Functional Materials in Nanoscience and Potential Application in Biomedicine

Amphiphilic “Like-A-Brush” Oligonucleotide Conjugates with Three Dodecyl Chains: Self-Assembly Features of Novel Scaffold Compounds for Nucleic Acids Delivery

Dynamic Nanostructures from DNA‐Coupled Molecules, Polymers, and Nanoparticles

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