Responsive block copolymers for drug delivery applications. Part 2: Exogenous stimuli-responsive drug-release systems

Johnson, Renjith P.; Preman, Namitha K.

doi:10.1016/b978-0-08-101997-9.00010-2

Cited by 5 publications

(5 citation statements)

References 65 publications

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“…Importantly, the use of appropriate polymers as reducing and stabilizing agents offers great advantages of simple and eco-friendly one-pot synthesis of AuNP in aqueous media with limited post-synthesis workup . Stimuli-responsive polymers demonstrate reversible–irreversible structural or physical property transformations in response to certain triggers like pH, − temperature, ionic strength, and light . Stimuli-responsive as well as charged (cationic or anionic) amphiphilic polymers offer excellent potential for the simultaneous protection, stabilization, and reduction of various metal salts to NPs .…”

Section: Resultsmentioning

confidence: 99%

“…38 Stimuli-responsive polymers demonstrate reversible−irreversible structural or physical property transformations in response to certain triggers like pH, 53−55 temperature, 56 ionic strength, and light. 57 Stimuli-responsive as well as charged (cationic or anionic) amphiphilic polymers offer excellent potential for the simultaneous protection, stabilization, and reduction of various metal salts to NPs. 58 Polymers with tertiary amine functionality are ideal for the simultaneous reduction and stabilization of metallic NPs in direct synthesis.…”

Section: Poly(pegema)-b-poly(dmaema)-mediated Direct Synthesis Of Aunpsmentioning

confidence: 99%

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Stimuli-Responsive Copolymer-Mediated Synthesis of Gold Nanoparticles for Nanozyme-Based Colorimetric Detection of Mercury(II) Ions

Preman

Jain

Antony

et al. 2023

ACS Appl. Polym. Mater.

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Mercury ion (Hg2+) is an extremely hazardous pollutant to humans, soil, and aquatic life. Nanozyme-based sensing approaches are promising for detecting toxic heavy metal ions. However, applying noble metal nanozymes in developing affordable and portable sensors remains largely unexplored. Herein, a gold nanoparticle (AuNP)-based colorimetric sensor was established for the ultra-trace detection of Hg2+ by capitalizing the inherent peroxidase-mimetic features of AuNPs for oxidizing the colorimetric indicator 3,3′,5,5′-tetramethylbenzidine (TMB) in the presence of hydrogen peroxide (H2O2). AuNPs of size less than 10 nm were directly prepared in aqueous media using a stimuli-responsive, poly(ethylene glycol methyl ether methacrylate)-b-poly(dimethylaminoethyl methacrylate (p(PEGEMA)-b-p(DMAEMA)) block copolymer, synthesized through RAFT polymerization. The block copolymers efficiently interacted with Au3+ ions toward the formation of stable, monodispersed AuNPs without additional reducing agents or stabilizers. Using TMB, H2O2, and the AuNP colorimetric system, the concentration of Hg2+ in aqueous media was quantitatively and selectively detected over those of other common interfering metal ions. The selective detection of Hg2+ was promoted by the Au-Hg amalgamation process, which is correlated with intensity of the colorimetric response. Colorimetrically, Hg2+ was linearly measured between 10 nM and 3.5 μM and achieved a detection limit of 0.4 nM. Subsequently, an on-field naked-eye sensing strategy was also developed by integrating the colorimetric sensor on a paper analytical device with a detection limit of 3.5 nM. The efficient colorimetric sensing platform for selective and trace detection of Hg2+ is promising for determining mercury contamination in different water and biological samples.

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Section: Resultsmentioning

confidence: 99%

Section: Poly(pegema)-b-poly(dmaema)-mediated Direct Synthesis Of Aunpsmentioning

confidence: 99%

Stimuli-Responsive Copolymer-Mediated Synthesis of Gold Nanoparticles for Nanozyme-Based Colorimetric Detection of Mercury(II) Ions

Preman

Jain

Antony

et al. 2023

ACS Appl. Polym. Mater.

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“…This ensures that the carriers can release the drug at the target site at the right time [115]. On the other hand, endogenous stimuli provide significant benefits for diseased tissues in the microenvironment, including pH variation, redox state, different levels of glutathione (GSH), blood glucose level, and specific enzyme triggers [114,116]. Therefore, endogenous stimuli-responsive drug delivery systems can reduce side effects, and serve as more effective therapeutics [117].…”

Section: Types Of Gating Structurementioning

confidence: 99%

Smart gating porous particles as new carriers for drug delivery

Thananukul

Kaewsaneha

Opaprakasit

et al. 2021

Advanced Drug Delivery Reviews

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“…Supramolecular structures that can undergo a reversible shape transformation are of great interest for the development of intelligent materials 1,2 and drug delivery approaches. [3][4][5][6] In particular, block copolymers (BCPs) are capable of creating a diverse array of nanostructures. [7][8][9] BCPs consist of two or more covalently-linked segments, whose chemical incompatibility results in microphase separation.…”

Section: Introductionmentioning

confidence: 99%

Photoresponsive block copolymer nanostructures through implementation of arylazopyrazoles

Ziegler,

Schlichter,

Post

et al. 2024

Preprint

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Responsive nanomaterials that can undergo reversible changes in morphology are interesting for the development of functional materials that interact with and respond to their environment. Amphiphilic block copolymers are well known for their ability to create a wide range of supramolecular nanostructures in solution. Arylazopyrazoles (AAPs) are versatile molecular photoswitches, which change their configuration and hydrophobicity via irradiation with UV light (365 nm, Z isomer, less hydrophobic) and green light (520 nm, E isomer, more hydrophobic). In this work, photoswitchable block copolymers containing arylazopyrazole tetraethylene glycol methacrylate (AAPMA) and oligo(ethylene glycol) methacrylate (OEGMA) forming amphiphilic POEGMA b PAAPMA with varying block lengths are prepared by RAFT polymerization. The photochemical properties of AAP persist in the polymers. Due to their amphiphilic structure, the polymers self-assemble into supramolecular morphologies in water. Remarkably, photoisomerization results in a reversible change in the self-assembly behavior. Specifically, spherical and cylindrical micelles are observed for POEGMA33-b-PAAPMA47 when illuminated under green or UV light during assembly. Furthermore, the morphology of assembled structures can be reversibly switched by subsequent irradiation with UV and green light.

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Responsive block copolymers for drug delivery applications. Part 2: Exogenous stimuli-responsive drug-release systems

Cited by 5 publications

References 65 publications

Stimuli-Responsive Copolymer-Mediated Synthesis of Gold Nanoparticles for Nanozyme-Based Colorimetric Detection of Mercury(II) Ions

Stimuli-Responsive Copolymer-Mediated Synthesis of Gold Nanoparticles for Nanozyme-Based Colorimetric Detection of Mercury(II) Ions

Smart gating porous particles as new carriers for drug delivery

Photoresponsive block copolymer nanostructures through implementation of arylazopyrazoles

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