Responsive and “smart” antibacterial surfaces: Common approaches and new developments (Review)

Cavallaro, Alex; Taheri, Shima; Vasilev, Krasimir

doi:10.1116/1.4866697

Cited by 59 publications

(41 citation statements)

References 126 publications

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“…Since medical device associated infections often begin with the attachment of a few individual planktonic bacteria to the surface of the device, a concept that has gained tremendous attention from researchers, industry and healthcare professionals is the prevention of the initial bacterial attachment by applying antibacterial coatings. The breadth of research activities in this area is enormous and has been reviewed by us and many other authors [2,[11][12][13]. In this invited feature article, the aim of the author is to summarise and place into perspective the research from our group on nanoengineered antibacterial surfaces and materials that was published over the last decade and is currently under development.…”

Section: Antibacterial Coatingsmentioning

confidence: 99%

Nanoengineered Antibacterial Coatings and Materials: A Perspective

Vasilev

2019

Coatings

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This feature article begins by outlining the problem of infection and its implication on healthcare. The initial introductory section is followed by a description of the four distinct classes of antibacterial coatings and materials, i.e., bacteria repealing, contact killing, releasing and responsive, that were developed over the years by our team and others. Specific examples of each individual class of antibacterial materials and a discussion on the pros and cons of each strategy are provided. The article contains a dedicated section focused on silver nanoparticle based coatings and materials, which have attracted tremendous interest from the scientific and medical communities. The article concludes with the author’s view regarding the future of the field.

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Section: Antibacterial Coatingsmentioning

confidence: 99%

Nanoengineered Antibacterial Coatings and Materials: A Perspective

Vasilev

2019

Coatings

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“…A major inherent drawback of bactericidal coatings is the accumulation of dead bacteria and other debris, which not only conceal the biocidal activity centers and decrease the biocidal efficacy against later‐adhering bacteria, but may also trigger immune responses or inflammation . It seems likely that the ideal antibacterial coating should have multiple functions that can be activated individually or in combination as required . It should be able to i) initiate biocidal activity when bacteria adhere to the surface while remaining “bioinert” in the absence of bacteria, ii) combine two or more killing mechanisms that act synergistically to enhance antibacterial efficacy, especially against MDR bacteria, and iii) remove dead bacteria and other debris, thereby recovering the “clean” surface and maintaining long‐term antibacterial activity.…”

Section: Introductionmentioning

confidence: 99%

Responsive and Synergistic Antibacterial Coatings: Fighting against Bacteria in a Smart and Effective Way

Wei

Chen

2019

Adv Healthcare Materials

302

207

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Antibacterial coatings that eliminate initial bacterial attachment and prevent subsequent biofilm formation are essential in a number of applications, especially implanted medical devices. Although various approaches, including bacteria‐repelling and bacteria‐killing mechanisms, have been developed, none of them have been entirely successful due to their inherent drawbacks. In recent years, antibacterial coatings that are responsive to the bacterial microenvironment, that possess two or more killing mechanisms, or that have triggered‐cleaning capability have emerged as promising solutions for bacterial infection and contamination problems. This review focuses on recent progress on three types of such responsive and synergistic antibacterial coatings, including i) self‐defensive antibacterial coatings, which can “turn on” biocidal activity in response to a bacteria‐containing microenvironment; ii) synergistic antibacterial coatings, which possess two or more killing mechanisms that interact synergistically to reinforce each other; and iii) smart “kill‐and‐release” antibacterial coatings, which can switch functionality between bacteria killing and bacteria releasing under a proper stimulus. The design principles and potential applications of these coatings are discussed and a brief perspective on remaining challenges and future research directions is presented.

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“…12,13 Additionally, the overuse of antimicrobial agents has contributed to the emergence of antibiotic-resistant pathogens. 14 As a result, new strategies for reducing surface fouling have shifted away from incorporation of toxic biocides towards more environmentally benign antifouling coatings, i.e. coatings that can minimise and prevent microbial interactions and adhesion.…”

Section: Introductionmentioning

confidence: 99%

Zwitterion Functionalized Silica Nanoparticle Coatings: The Effect of Particle Size on Protein, Bacteria, and Fungal Spore Adhesion

et al. 2018

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The negative impacts that arise from biological fouling of surfaces have driven the development of coatings with unique physical and chemical properties that are able to prevent interactions with fouling species. Here, we report on low-fouling hydrophilic coatings presenting nanoscaled features prepared from different size silica nanoparticles (SiNPs) functionalized with zwitterionic chemistries. Zwitterionic sulfobetaine siloxane (SB) was reacted to SiNPs ranging in size from 7 to 75 nm. Particle stability and grafting density were confirmed using dynamic light scattering and thermogravimetric analysis. Thin coatings of nanoparticles were prepared by spin-coating aqueous particle suspensions. The resulting coatings were characterized using scanning electron microscopy, atomic force microscopy, and contact angle goniometry. SB functionalized particle coatings displayed increased hydrophilicity compared to unmodified particle coating controls while increasing particle size correlated with increased coating roughness and increased surface area. Coatings of zwitterated particles demonstrated a high degree of nonspecific protein resistance, as measured by quartz crystal microgravimetry. Adsorption of bovine serum albumin and hydrophobin proteins were reduced by up to 91 and 94%, respectively. Adhesion of bacteria ( Escherichia coli) to zwitterion modified particle coatings were also significantly reduced over both short and long-term assays. Maximum reductions of 97% and 94% were achieved over 2 and 24 h assay periods, respectively. For unmodified particle coatings, protein adsorption and bacterial adhesion were generally reduced with increasing particle size. Adhesion of fungal spores to SB modified SiNP coatings was also reduced, however no clear trends in relation to particle size were demonstrated.

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Responsive and “smart” antibacterial surfaces: Common approaches and new developments (Review)

Cited by 59 publications

References 126 publications

Nanoengineered Antibacterial Coatings and Materials: A Perspective

Nanoengineered Antibacterial Coatings and Materials: A Perspective

Responsive and Synergistic Antibacterial Coatings: Fighting against Bacteria in a Smart and Effective Way

Zwitterion Functionalized Silica Nanoparticle Coatings: The Effect of Particle Size on Protein, Bacteria, and Fungal Spore Adhesion

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