Responses to Exercise in Children With Sickle Cell Trait

Alpert, Bruce S.; Flood, Nadine L.; Strong, William B.; Blair, John R.; Walpert, J B.; Levy, Arden

doi:10.1001/archpedi.1982.03970470046013

Cited by 11 publications

(6 citation statements)

References 9 publications

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“…Francis & Bleakley (1980) reported that cardiac responses to exercise did not differ between SCT and control subjects. In contrast, Alpert et al (1982) found that 8AE3% of children with SCT had electrocardiographic (ECG) changes during exercise which were suggestive of ischaemia, compared with 2AE3% of the control subjects. Pearl et al (1994), by comparing ECG between SCT carriers and control subjects in resting condition and during exercise both at sea level and at altitude, found significant differences in six ECG variables, the resting ECGs at sea level showing the greatest differences.…”

Section: Introductionmentioning

confidence: 87%

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Nocturnal autonomic nervous system activity impairment in sickle cell trait carriers

Connes

Martin

Barthélémy³

et al. 2006

Clin Physio Funct Imaging

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Sickle cell trait (SCT) is a genetic disease affecting the synthesis of normal haemoglobin (Hb) and marked by the heterozygous presence of HbA and HbS. Some studies have suggested that SCT carriers might be prone to vascular alterations, cardiac ischaemia and arrhythmias leading, in some subjects, to sudden death. It is well known that a loss or a disequilibrium of autonomic activity are powerful predictors of sudden cardiac death. We hypothesized that SCT subjects might exhibit alterations in the activity of the autonomic nervous system that could constitute further risk factors for cardiac complications. Resting haemorheological parameters (eta(b), blood viscosity; eta(p), plasma viscosity; Hct, haematocrit; Tk, red blood cell rigidity), and sympathetic and parasympathetic indices of nocturnal autonomic activity (temporal and frequency analysis of heart rate variability) were thus compared between a group of nine SCT subjects and a group of nine control subjects. eta(b) was higher in the SCT group than in the control group while Hct, eta(p) and Tk were not different. Global variability (SDNN, SDNNIDX) and parasympathetic (PNN50, RMSSD, HF) indices were significantly lower in the SCT group compared with the control group, while the LF/HF ratio was highly increased, underlining a major sympathetic shift. The autonomic imbalance in SCT subjects was mainly related to lowered parasympathetic activity. Thus, our study suggests an additional global decrease and imbalance of autonomic nervous system activity to biological disorders of SCT carriers, that may constitute further risk factors for cardiac complications in this population.

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Section: Introductionmentioning

confidence: 87%

“…Francis & Bleakley (1980) reported that cardiac responses to exercise did not differ between SCT and control subjects. In contrast, Alpert et al. (1982) found that 8·3% of children with SCT had electrocardiographic (ECG) changes during exercise which were suggestive of ischaemia, compared with 2·3% of the control subjects.…”

Section: Introductionmentioning

confidence: 88%

Nocturnal autonomic nervous system activity impairment in sickle cell trait carriers

Connes

Martin

Barthélémy³

et al. 2006

Clin Physio Funct Imaging

View full text Add to dashboard Cite

show abstract

“…4) Studies on exercise tolerance in subjects with SCT. The cardiac responses to exercise in children (1) and in men and women with SCT (8) were similar to those of control subjects. Cardiopulmonary and gas exchange responses to acute strenuous exercise at low altitude (1,270 m;Ref.…”

mentioning

confidence: 57%

Point:Counterpoint: Sickle cell trait should/should not be considered asymptomatic and as a benign condition during physical activity

Gallais

Lonsdorfer²,

Bogui³

et al. 2007

Journal of Applied Physiology

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“…Le tracé de repos montre souvent des signes de nécrose myocardique transmurale onde Q en V1 V2 V3 antéroseptal ou de topographie latérale en D1 AVL sans valeur chez l'enfant ; l'épreuve d'effort les dépiste le seuil d'apparition des signes ischémiques est plus précoce dans l'anémie drépanocytaire que dans l'anémie chronique un sous décalage de -1 mm en V5 est suggestif d'ischémie myocardique chez le drépanocytaire. Alpert et al [8] retrouvent 15 % de test d'effort positif dans une population d'enfants drépano-cytaire.…”

Section: Dépister Systématiquement Les Signes D'ischémie Myocardiqueunclassified

Bloc auriculo-ventriculaire transitoire aigu dans la drépanocytose. Première série

Gacon

Jourdain²,

Heba

et al. 2014

Annales de Cardiologie et d'Angéiologie

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Responses to Exercise in Children With Sickle Cell Trait

Cited by 11 publications

References 9 publications

Nocturnal autonomic nervous system activity impairment in sickle cell trait carriers

Nocturnal autonomic nervous system activity impairment in sickle cell trait carriers

Point:Counterpoint: Sickle cell trait should/should not be considered asymptomatic and as a benign condition during physical activity

Bloc auriculo-ventriculaire transitoire aigu dans la drépanocytose. Première série

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