Responses to cadmium intoxication in the liver of the wall lizard Podarcis sicula

Simoniello, Palma; Filosa, Stefania; Riggio, Marilisa; Scudiero, Rosaria; Tammaro, S.; Trinchella, Francesca; Motta, Chiara Maria

doi:10.1016/j.cbpc.2009.10.005

Cited by 30 publications

(43 citation statements)

References 37 publications

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“…The increase in HM concentration in the cells stimulates the de novo synthesis of apothioneins that can bind metal cations in a non-toxic form, thus reducing their deleterious effects (Klaassen et al, 2009;Simoniello et al, 2010).…”

Section: Mts In Cladophora Treated With Different Pb Concentrationsmentioning

confidence: 99%

Effects of lead on tolerance, bioaccumulation, and antioxidative defense system of green algae, Cladophora

Cao

Shi

et al. 2015

Ecotoxicology and Environmental Safety

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Section: Mts In Cladophora Treated With Different Pb Concentrationsmentioning

confidence: 99%

Effects of lead on tolerance, bioaccumulation, and antioxidative defense system of green algae, Cladophora

Cao

Shi

et al. 2015

Ecotoxicology and Environmental Safety

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“…For histological analysis samples were fixed in 4% formaldehyde and processed as described. 13 Samples for protein extraction were acquired as well and were immediately placed on dry ice. After fixation, samples were wax embedded and cut with a microtome.…”

Section: Pathohistological Examinationmentioning

confidence: 99%

“…13,15 Used antibodies were anti-caspase 3, anti-poly ADP ribose polymerase (Cell Signaling), antitubuline (Sigma Aldrich), and horseradish peroxidase-conjugated secondary antibodies (GE Healthcare Life Sciences). Protein expression was visualized using enhanced chemiluminescence (ECL, Amersham Biosciences) and detected on films (ECL-Hyperfilm, Amersham Biosciences).…”

Section: Protein Extraction and Western Blottingmentioning

confidence: 99%

Atrioventricular Node Ablation in Langendorff-Perfused Porcine Hearts Using Carbon Ion Particle Therapy

Lehmann

Richter

Prokesch

et al. 2015

Circ: Arrhythmia and Electrophysiology

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Background— Particle therapy, with heavy ions such as carbon-12 ( 12 C), delivered to arrhythmogenic locations of the heart could be a promising new means for catheter-free ablation. As a first investigation, we tested the feasibility of in vivo atrioventricular node ablation, in Langendorff-perfused porcine hearts, using a scanned 12C beam. Methods and Results— Intact hearts were explanted from 4 (30–40 kg) pigs and were perfused in a Langendorff organ bath. Computed tomgraphic scans (1 mm voxel and slice spacing) were acquired and 12 C ion beam treatment planning (optimal accelerator energies, beam positions, and particle numbers) for atrioventricular node ablation was conducted. Orthogonal x-rays with matching of 4 implanted clips were used for positioning. Ten Gray treatment plans were repeatedly administered, using pencil beam scanning. After delivery, positron emission tomography-computed tomgraphic scans for detection of β + ( 11 C) activity were obtained. A 12 C beam with a full width at half maximum of 10 mm was delivered to the atrioventricular node. Delivery of 130 Gy caused disturbance of atrioventricular conduction with transition into complete heart block after 160 Gy. Positron emission computed tomgraphy demonstrated dose delivery into the intended area. Application did not induce arrhythmias. Macroscopic inspection did not reveal damage to myocardium. Immunostaining revealed strong γH2AX signals in the target region, whereas no γH2AX signals were detected in the unirradiated control heart. Conclusions— This is the first report of the application of a 12 C beam for ablation of cardiac tissue to treat arrhythmias. Catheter-free ablation using 12C beams is feasible and merits exploration in intact animal studies as an energy source for arrhythmia elimination.

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“…Couillard, Laplatte, & Pelletier, 2009;Dang & Wang, 2009;Horng, Lin, & Lee, 2010;Scholz et al, 2008) or other animals (e.g. Simoniello et al, 2010) are available in the literature and provide data on the toxicity mode of action that are very useful also for application to human toxicity. It is important to stress that some animals of relevance for ecotoxicology are widely studied also in other disciplines.…”

Section: Current Status Of Animal Testing For Food Contaminantsmentioning

confidence: 99%

New tools to assess toxicity, bioaccessibility and uptake of chemical contaminants in meat and seafood

Marques

Lourenço

Nunes

et al. 2011

Food Research International

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Responses to cadmium intoxication in the liver of the wall lizard Podarcis sicula

Cited by 30 publications

References 37 publications

Effects of lead on tolerance, bioaccumulation, and antioxidative defense system of green algae, Cladophora

Effects of lead on tolerance, bioaccumulation, and antioxidative defense system of green algae, Cladophora

Atrioventricular Node Ablation in Langendorff-Perfused Porcine Hearts Using Carbon Ion Particle Therapy

New tools to assess toxicity, bioaccessibility and uptake of chemical contaminants in meat and seafood

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