Responses of total and free insulin‐like growth factor‐I and insulin‐like growth factor binding protein‐3 after resistance exercise and training in elderly subjects

Bermon, Stéphane; Ferrari, P.; Bernard, Patrice; Altare, S; Dolisi, C.

doi:10.1046/j.1365-201x.1999.00471.x

Cited by 77 publications

(55 citation statements)

References 29 publications

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“…Most IGF-I (∼80%) circulates in a 150-kDa, high-affinity complex, which also contains IGFBP-3 and an acid-labile subunit. Analogous to the present findings, studies have found no change in IGF-I and IGFBP-3 concentrations following 8 (Bermon et al 1999) and 12 weeks (Kraemer et al 1999) of resistance training in a similarly aged population. In contrast, a significant increase in plasma IGF-I concentrations following an acute exercise bout was reported in one of these studies (Bermon et al 1999).…”

Section: Molecular Background Of the Observed In Vivo Muscle Charactesupporting

confidence: 68%

“…Analogous to the present findings, studies have found no change in IGF-I and IGFBP-3 concentrations following 8 (Bermon et al 1999) and 12 weeks (Kraemer et al 1999) of resistance training in a similarly aged population. In contrast, a significant increase in plasma IGF-I concentrations following an acute exercise bout was reported in one of these studies (Bermon et al 1999). In endurance training studies, IGFBP-3 has been shown to be independent of IGF-I responses and potentially to have its own biological activity at the level of the cell (Jones and Clemmons 1995).…”

Section: Molecular Background Of the Observed In Vivo Muscle Charactesupporting

confidence: 68%

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Influence of exercise intensity in older persons with unchanged habitual nutritional intake: skeletal muscle and endocrine adaptations

Onambélé-Pearson

Breen

Stewart

2010

AGE

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Long-term adherence to training programmes is difficult to attain. Yet, the benefits of exercise to general health and well-being are undeniable. Any measure to demonstrate the minimum required exercise for maximal benefit to a person is a promising avenue towards increasing the uptake and adherence to physical activity for the general public. The purpose of this study was to compare the effects of two different intensities of resistance training in healthy older adults. We hypothesised that compared to high-intensity resistance exercise, relatively low training intensity could also improve in vivo markers of healthy physiologic and endocrine functions in previously sedentary older individuals. Thirty (out of a possible 34 recruited) older adults were randomly assigned to low (LowR, i.e. ∼40% one repetition maximum (1RM)) versus high-resistance training (HighR, i.e. ∼80% 1RM) for 12 weeks. Neither intervention significantly impacted upon body composition markers including: body mass index (BMI), waist/hip ratio and bioelectric impedance. Muscle strength data showed an advantage for the HighR protocol with 51±4% and 22.4±10.2% (P<0.05) improvements in 1RM strength and bilateral knee extension torque, respectively, compared with 17±1% and 10.3±4.7% (P<0.05) increments in 1RM strength and bilateral torque in the LowR group. Unilateral torque did not change significantly in either group. Quadriceps muscle thickness data also showed a significantly greater benefit of the HighR protocol (5.8±2.6% increase) compared with the LowR protocol (no change). Functional ability tests, including Get-up-and-go (GUG), Standing from lying and the 6-min walk, showed changes of −11.6 ± 4.8%, −15.6% and 8.5±1.7% (P<0.05), respectively, in HighR compared with only one significant improvement in the LowR, namely a −10.8±3% (P<0.05) improvement in the GUG test. Overnight fasting serum levels of IGFBP-3 increased, NPY decreased and TNF-α decreased significantly in the LowR group. Serum levels of glucose increased and NPY decreased significantly in HighR. Circulating levels of I, IL-6 and IGF-1 did not change with either intervention. In vivo physiologic changes show functional advantages for older persons carrying out AGE (2010) 32:139-153

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Section: Molecular Background Of the Observed In Vivo Muscle Charactesupporting

confidence: 68%

Section: Molecular Background Of the Observed In Vivo Muscle Charactesupporting

confidence: 68%

Influence of exercise intensity in older persons with unchanged habitual nutritional intake: skeletal muscle and endocrine adaptations

Onambélé-Pearson

Breen

Stewart

2010

AGE

View full text Add to dashboard Cite

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“…This finding supports the hypothesis that local exercise-induced mobilization of tissue-bound IGF-I stores affects local levels of IGF-I in the exercising muscle. In previous exercise studies, circulating f-IGF-I has been determined in an antecubital vein and has been reported to be increased (51) or unchanged (52). In the present study, the quantity of f-IGF-I released was not sufficient to be detectable in the large pool of t-IGF-I in the circulation.…”

Section: Discussionmentioning

confidence: 54%

Interstitial IGF-I in exercising skeletal muscle in women

et al. 2007

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Objective: To study interstitial IGF-I concentrations in resting and exercising skeletal muscle in relation to the circulating components of the IGF-IGF binding protein (IGFBP) system. Design and methods: Seven women performed endurance exercise with 1 leg (Ex-leg) for 1 h. The resting leg (Rest-leg) served as a control. IGF-I was determined in microdialysate (MD) and was compared with veno-arterial (v-a) concentrations of circulating IGF-IGFBP components. Results: Median (range) basal MD-IGF-I was 0.87 (0.4-1.5) mg/l or 0.4 (0.2)% of total-IGF-I (t-IGF-I) determined in arterial serum and in the same concentration range as free dissociable IGF-I (f-IGF-I). Rest-leg MD-IGF-I decreased, reaching significance after exercise. Ex-leg MD-IGF-I was unchanged during exercise and declined after exercise at the level of significance (PZ0.05). There was a release of f-IGF-I from the Ex-leg into the circulation at the end of and shortly after exercise. A small but significant increase in circulating IGFBP-1 was detected at the end of exercise and IGFBP-1 increased further after exercise. Although interleukin-6 (IL-6) has been associated with IGFBP-3 proteolysis, the circulating molecular forms of IGFBP-3 remained unchanged in spite of an IL-6 release from the muscle compartment. Conclusions: Circulating IGFBP-1 is related to interstitial IGF-I in resting muscle although the temporal relationship may not be simple. Further studies should explore the role of local release of IGF-I and its impact on IGF-I activity during contraction.

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“…Effect of exercise on IGF-1 system is one aspect that has been investigated by many researchers [3][4][5][6]. Though, few studies showed concern in studying the response of IGF-1 system to resistance exercise [7,8]. Bermon et al [7] examined the impact of a single session of resistance exercise on the levels of IGF-1 in elderly subjects, and found an increase in IGF-1 concentrations after exercise with no significant change in insulin-like growth factor binding protein-3 (IGFBP3) levels.…”

Section: Introductionmentioning

confidence: 99%

Time course responses of serum GH, insulin, IGF-1, IGFBP1, and IGFBP3 concentrations after heavy resistance exercise in trained and untrained men

et al. 2011

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To investigate the effect of heavy resistance exercise on IGF-1 system, 19 healthy trained men and 15 healthy untrained men volunteered to participate in this study. The subjects were randomly divided into experimental and control groups. Subjects of experimental groups were forced to perform a heavy resistance exercise with the intensity of 70-80% of 1RM in selected movements. The blood samples were taken from all subjects four times; before (T1), immediately after (T2), 5 (T3), and 8 (T4) hours after exercise. Analysis of data showed that a session of heavy resistance exercise induced significant increase in GH at T2 (P < 0.05) and a significant decrease in insulin at T4 (P < 0.05) and a significant decrease in IGFBP3 at T4 (P < 0.05) in trained group. In untrained group, no significant change in any of the variables was observed. However, the procedure of response in variables was almost similar in two experimental groups. Although, the exercise did not appreciably affect IGF-1 levels, it decreased in all groups at length of time after exercise. In addition, the exercise did not have any notable effect on IGFBP1 levels over time. In conclusion, the findings of this study indicate that the intense resistance exercise can lead to changes in blood concentrations of IGF-1 system components which are observable in blood circulation over time and the amounts of changes depend on subjects' fitness levels and exercise variables.

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Responses of total and free insulin‐like growth factor‐I and insulin‐like growth factor binding protein‐3 after resistance exercise and training in elderly subjects

Cited by 77 publications

References 29 publications

Influence of exercise intensity in older persons with unchanged habitual nutritional intake: skeletal muscle and endocrine adaptations

Influence of exercise intensity in older persons with unchanged habitual nutritional intake: skeletal muscle and endocrine adaptations

Interstitial IGF-I in exercising skeletal muscle in women

Time course responses of serum GH, insulin, IGF-1, IGFBP1, and IGFBP3 concentrations after heavy resistance exercise in trained and untrained men

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