Responses of the nucleus accumbens following fornix/fimbria stimulation in the rat. Identification and long-term potentiation of mono- and polysynaptic pathways

Boeijinga, Peter H.; Mulder, A. H.; Pennartz, Cyriel M. A.; Manshanden, Ilonka; Silva, F.H. Lopes da

doi:10.1016/0306-4522(93)90488-2

Cited by 68 publications

(55 citation statements)

References 23 publications

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“…Based on experiments in which a single 2% solution of lidocaine was perfused (to test probe functioning), the onset of the effect was determined at 5 to 6 min after brain entrance (data not shown), similar to the onset observed during recordings with the concentration effect curve. Neuronal activity (partially) recovered after 30 min, which is in accordance with previous findings after local injections (Albert and Madryga, 1980;Boeijinga et al, 1993;Tehovnik and Sommer, 1997) or reverse dialysis (Boehnke and Rasmusson, 2001).…”

Section: Discussionsupporting

confidence: 91%

Pharmacological Manipulation of Neuronal Ensemble Activity by Reverse Microdialysis in Freely Moving Rats: A Comparative Study of the Effects of Tetrodotoxin, Lidocaine, and Muscimol

Duuren

Plasse²,

Blom³

et al. 2007

J Pharmacol Exp Ther

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To be able to address the question how neurotransmitters or pharmacological agents influence activity of neuronal populations in freely moving animals, the combidrive was developed. The combidrive combines an array of 12 tetrodes to perform ensemble recordings with a moveable and replaceable microdialysis probe to locally administer pharmacological agents. In this study, the effects of cumulative concentrations of tetrodotoxin, lidocaine, and muscimol on neuronal firing activity in the prefrontal cortex were examined and compared. These drugs are widely used in behavioral studies to transiently inactivate brain areas, but little is known about their effects on ensemble activity and the possible differences between them. The results show that the combidrive allows ensemble recordings simultaneously with reverse microdialysis in freely moving rats for periods at least up to 2 wk. All drugs reduced neuronal firing in a concentration dependent manner, but they differed in the extent to which firing activity of the population was decreased and the in speed and extent of recovery. At the highest concentration used, both muscimol and tetrodotoxin (TTX) caused an almost complete reduction of firing activity. Lidocaine showed the fastest recovery, but it resulted in a smaller reduction of firing activity of the population. From these results, it can be concluded that whenever during a behavioral experiment a longer lasting, reversible inactivation is required, muscimol is the drug of choice, because it inactivates neurons to a similar degree as TTX, but it does not, in contrast to TTX, affect fibers of passage. For a short-lasting but partial inactivation, lidocaine would be most suitable.Until recently, neurophysiological analysis of information processing in the brain was primarily based on the examination of firing activity of single cells during behavior, as measured with repetitive presentations of stimuli (Gerstein and Kiang, 1960). However, this could not provide an answer to the question of how information is represented by the pattern of activity distributed across a population of neurons. With the emergence of techniques to record large numbers of neurons simultaneously ("ensemble recordings"), it became possible to examine information coding at the level of cell populations (Wilson and McNaughton, 1993). However, an issue that has not been addressed thus far is how neurotransmitters influence the activity of these cell populations.To gain more insight in the interaction between neurotransmitters or pharmacological agents and neuronal firing activity, we sought to develop a method in which drugs could be locally administered while performing ensemble recordings in freely moving rats. Because drugs should ideally be delivered with a constant concentration throughout the experimental session within the entire recording area, reverse microdialysis is preferred over either local injections, because with injections additional fluid is introduced into the brain, causing a change in pressure; or iontophoresis,...

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Section: Discussionsupporting

confidence: 91%

Pharmacological Manipulation of Neuronal Ensemble Activity by Reverse Microdialysis in Freely Moving Rats: A Comparative Study of the Effects of Tetrodotoxin, Lidocaine, and Muscimol

Duuren

Plasse²,

Blom³

et al. 2007

J Pharmacol Exp Ther

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“…5) argues in favor of a close temporal and functional linkage. Furthermore, unit responses resembled firing patterns observed in VS after electrical stimulation of the fimbria-fornix or CA1-subiculum (Pennartz and Kitai, 1991;Boeijinga et al, 1993;Mulder et al, 1998). Recently, negative field potential shifts in rat hippocampus under anesthesia were shown to correlate to transitions to the "up" state in VS neurons (Goto and O'Donnell, 2001), also supporting a strong functional linkage.…”

Section: Ripple Modulation and Off-line Reactivation: A Hypothesismentioning

confidence: 61%

The Ventral Striatum in Off-Line Processing: Ensemble Reactivation during Sleep and Modulation by Hippocampal Ripples

et al. 2004

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Previously it has been shown that the hippocampus and neocortex can spontaneously reactivate ensemble activity patterns during post-behavioral sleep and rest periods. Here we examined whether such reactivation also occurs in a subcortical structure, the ventral striatum, which receives a direct input from the hippocampal formation and has been implicated in guidance of consummatory and conditioned behaviors. During a reward-searching task on a T-maze, flanked by sleep and rest periods, parallel recordings were made from ventral striatal ensembles while EEG signals were derived from the hippocampus. Statistical measures indicated a significant amount of reactivation in the ventral striatum. In line with hippocampal data, reactivation was especially prominent during postbehavioral slow-wave sleep, but unlike the hippocampus, no decay in pattern recurrence was visible in the ventral striatum across the first 40 min of post-behavioral rest. We next studied the relationship between ensemble firing patterns in ventral striatum and hippocampal ripples-sharp waves, which have been implicated in pattern replay. Firing rates were significantly modulated in close temporal association with hippocampal ripples in 25% of the units, showing a marked transient enhancement in the average response profile. Strikingly, ripple-modulated neurons in ventral striatum showed a clear reactivation, whereas nonmodulated cells did not. These data suggest, first, the occurrence of pattern replay in a subcortical structure implied in the processing and prediction of reward and, second, a functional linkage between ventral striatal reactivation and a specific type of high-frequency population activity associated with hippocampal replay.

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“…1), which have been described previously (Boeijinga et al, 1993;Mulder et al, 1997). In short, the EFP consisted of two positive synaptic components: the latency of the first one was 10 msec on average (P10, monosynaptically driven), and the latency of the second one was 25 msec (P25, polysynaptically driven) ( Fig.…”

Section: Evoked Field Potentialsmentioning

confidence: 99%

Electrophysiology of the Hippocampal and Amygdaloid Projections to the Nucleus Accumbens of the Rat: Convergence, Segregation, and Interaction of Inputs

1998

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The nucleus accumbens (Nacb) receives inputs from hippocampus and amygdala but it is still unclear how these inputs are functionally organized and may interact. The interplay between these input pathways was examined using electrophysiological tools in the rat, in vivo, under halothane anesthesia. After fornix/fimbria stimulation (Fo/Fi, subicular projection fibers to the Nacb), mono-and polysynaptically driven single units were recorded in the medial shell/core regions of the Nacb and in the ventromedial caudate putamen. Monosynaptically driven neurons by basolateral amygdala (BLA) stimulation were found in the medial shell/core and in the ventrolateral shell/core regions. In the areas of convergence (medial shell/core), paired activation of BLA followed by that of Fo/Fi resulted in an enhancement of the Fo/Fi response, whereas stimulation in the reverse order, Fo/Fi followed by BLA, led to a depression of the BLA response. In addition to these patterns of interactions, the tetanization of the Fo/Fi to Nacb pathway caused a homosynaptic decremental (long-term) potentiation in the Nacb, accompanied by a heterosynaptic (long-term) depression of the nontetanized BLA to Nacb pathway. We postulate that the hippocampal inputs may close a "gate" for the amygdala inputs, whereas the gate is opened for the hippocampus inputs by previous amygdalar activity. These opposite effects on the Nacb neuronal populations should be taken into account when interpreting behavioral phenomena, particularly with respect to the contrasting effects of the amygdala and the hippocampus in locomotion and place learning.

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Responses of the nucleus accumbens following fornix/fimbria stimulation in the rat. Identification and long-term potentiation of mono- and polysynaptic pathways

Cited by 68 publications

References 23 publications

Pharmacological Manipulation of Neuronal Ensemble Activity by Reverse Microdialysis in Freely Moving Rats: A Comparative Study of the Effects of Tetrodotoxin, Lidocaine, and Muscimol

Pharmacological Manipulation of Neuronal Ensemble Activity by Reverse Microdialysis in Freely Moving Rats: A Comparative Study of the Effects of Tetrodotoxin, Lidocaine, and Muscimol

The Ventral Striatum in Off-Line Processing: Ensemble Reactivation during Sleep and Modulation by Hippocampal Ripples

Electrophysiology of the Hippocampal and Amygdaloid Projections to the Nucleus Accumbens of the Rat: Convergence, Segregation, and Interaction of Inputs

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