Responses of the Human Eccrine Sweat Duct to Controlled Injury

Isolation and Characterization of Sweat Gland Myoepithelial Cells from Human Skin

“…Lobitz et al (1954) suggested that "partial" sweat glands, in which the epidermal sweat duct unit was removed after superficial epidermal injury, regenerated the epidermal duct of sweat glands (Lobitz et al, 1954). The ability of sweat glands to regenerate the straight duct was supported by the observation that the residues of human sweat glands following dermal trauma regenerated the dermal duct of sweat glands (Lobitz et al, 1956).…”

Markers of Epidermal Stem Cell Subpopulations in Adult Mammalian Skin

“…However, in murine skin, sweat glands are restricted to non-hair-bearing areas such as the footpads. Work from the 1950s suggested that human sweat gland stem cells reside within the basal layer of the sweat duct close to where it becomes contiguous with the epidermis (Lobitz et al 1954). Later studies showed that human eccrine sweat gland stem cells are capable of reconstituting the entire epidermis on grafting (Biedermann et al 2010).…”

Cellular mechanisms of skin repair in humans and other mammals

“…The dramatic increase in mitotic activity in bodily eccrine sweat glands upon wounding noted above suggests that eccrine sweat gland stem cells also contribute progeny for reepithelialization. Eccrine sweat glands are able to repair their acrosyringium (intra-epidermal portion of the sweat gland) upon damage to the stratum corneum [shown in humans: (Lobitz et al 1954) and mice: (Lu et al 2012)]. In mice, epidermal scratch wound triggered a very minimal epidermal infiltration of sweat gland-derived cells after wounding (Lu et al 2012), suggesting that many regenerative cells of the hyper-proliferative epidermis originated from neighboring epidermis.…”

“…It is assumed that eccrine sweat glands are maintained by their own stem cell populations as well, although human bodily eccrine sweat glands are remarkably devoid of mitosis in basal conditions, suggesting an extremely low cell turnover [shown in humans: (Holyoke and Lobitz 1952;Lobitz et al 1954;Rittié et al 2013aRittié et al , 2016]. However, this turnover dramatically increases upon wounding [shown in humans: (Lobitz et al 1954;Rittié et al 2013aRittié et al , 2016] or in eccrine sweat glands of skin located near surgical sites (Morimoto and Saga 1995). These observations suggest the presence of adult stem cells in bodily eccrine sweat glands, as it is the case of paw stem cells in mice (Lu and Fuchs 2014).…”