Responses of serum neurotrophic factors to exercise in pregnant and postpartum women

Vega, Sandra Rojas; Kleinert, Jens; Sulprizio, Marion; Hollmann, W; Bloch, Wilhelm; Strüder, Heiko K.

doi:10.1016/j.psyneuen.2010.07.012

Cited by 48 publications

(11 citation statements)

References 49 publications

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“…Furthermore, several studies have reported a high BDNF concentration at rest after acute exercise [ 8 , 25 ]. The results for the high intensity aerobic exercise group in the present study showed a similar trend as other recently conducted studies that have reported an increase in serum BDNF concentration at rest after the long-term endurance training [ 6 – 9 ].…”

Section: Discussionmentioning

confidence: 99%

The effect of exercise intensity on brain derived neurotrophic factor and memory in adolescents

Jeon

2017

Environ Health Prev Med

128

115

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BackgroundBrain derived neurotrophic factor (BDNF) seems to serve as an important regulatory mechanism in the growth and development of neurons in many areas of the brain.Insulin-like growth factor 1 (IGF-1) is related to neurogenesis and regulation of the BDNF gene and is involved in the growth and differentiation of neurons.Cortisol is released in response to stimuli such as psychological oppression, anxiety, and fear. Stress also induces changes in BDNF. The purpose of this study was thus to examine the effects of varying intensities of aerobic exercise on resting serum BDNF, IGF-1 concentrations, cortisol, and memory of adolescents.MethodsForty male students with no history of physical illness from the middle school by participated in this study. Participants were randomly assigned to low, moderate, or high intensity treadmill exercise group, or a stretching (control) group. Exercise was performed 4 times per week for 12 weeks. Body composition, brain derived neurotrophic factor levels, insulin-like growth factor 1 levels, cortisol levels, and working memory were assessed.ResultsThe high intensity exercise group showed a significant increase in brain derived neurotrophic factor at rest, concentration level of insulin-like growth factor 1, cortisol, and working memory. For resting brain derived neurotrophic factor, the high intensity exercise group showed a more significant increase compared to the low intensity aerobic and stretching groups. The change in the working memory significantly increased for the high intensity exercise group compared to the low intensity aerobic group, moderate intensity exercise group, and stretching group.ConclusionsIn adolescents, whose brains are still developing, aerobic exercise of moderate to high intensity levels seems to have a positive effect on levels of serum brain derived neurotrophic factor at rest and on cognitive functioning.Trial registration EHPM-D-16-00107R2. ICMJE. 12 July 2016.

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Section: Discussionmentioning

confidence: 99%

The effect of exercise intensity on brain derived neurotrophic factor and memory in adolescents

Jeon

2017

Environ Health Prev Med

128

115

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“… 62 BDNF can pass the placental barrier. 65 Its plasma concentrations are higher among active than sedentary women, 66 and this may affect fetal cerebral development. All of these mechanisms remain to be confirmed in humans.…”

Section: Commented Resultsmentioning

confidence: 99%

Beneficial Effects of Maternal Physical Activity during Pregnancy on Fetal, Newborn, and Child Health: Guidelines for Interventions during the Perinatal Period from the French National College of Midwives

Guinhouya¹,

Duclos

Enéa

et al. 2022

J Midwife Womens Health

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The objective of this work is to synthesize current knowledge about the effects of maternal physical activity during pregnancy on children's health. During the prenatal and postnatal periods, maternal physical activity has protective effects against the risks of macrosomia, obesity, and other associated cardiometabolic disorders. Even though longitudinal studies in humans are still necessary to validate them, these effects have been consistently observed in animal studies. A remarkable effect of maternal physical activity is its positive role on neurogenesis, language development, memory, and other cognitive functions related to learning.

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“…High levels of leisure-time physical activity (e.g., jogging, aerobics, yoga, weight-lifting) during pregnancy are associated with increased vocabulary in offspring [74]. Exercise increases the plasma levels of IGF1 and BDNF with maternal hormonal changes in pregnancy [75]. The level of IGFBP-2, an inhibitory factor of IGF, is increased [76, 77], while insulin and IGF1 responsiveness are reduced in the AD patients [78].…”

Section: Discussionmentioning

confidence: 99%

Enriched gestation activates the IGF pathway to evoke embryo-adult benefits to prevent Alzheimer’s disease

Liu

Zhou

Xie

et al. 2019

Transl Neurodegener

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Background Building brain reserves before dementia onset could represent a promising strategy to prevent Alzheimer’s disease (AD), while how to initiate early cognitive stimulation is unclear. Given that the immature brain is more sensitive to environmental stimuli and that brain dynamics decrease with ageing, we reasoned that it would be effective to initiate cognitive stimulation against AD as early as the fetal period. Methods After conception, maternal AD transgenic mice (3 × Tg AD) were exposed to gestational environment enrichment (GEE) until the day of delivery. The cognitive capacity of the offspring was assessed by the Morris water maze and contextual fear-conditioning tests when the offspring were raised in a standard environment to 7 months of age. Western blotting, immunohistochemistry, real-time PCR, immunoprecipitation, chromatin immunoprecipitation (ChIP) assay, electrophysiology, Golgi staining, activity assays and sandwich ELISA were employed to gain insight into the mechanisms underlying the beneficial effects of GEE on embryos and 7–10-month-old adult offspring. Results We found that GEE markedly preserved synaptic plasticity and memory capacity with amelioration of hallmark pathologies in 7–10-m-old AD offspring. The beneficial effects of GEE were accompanied by global histone hyperacetylation, including those at bdnf promoter-binding regions, with robust BDNF mRNA and protein expression in both embryo and progeny hippocampus. GEE increased insulin-like growth factor 1 (IGF1) and activated its receptor (IGF1R), which phosphorylates Ca 2+ /calmodulin-dependent kinase IV (CaMKIV) at tyrosine sites and triggers its nuclear translocation, subsequently upregulating histone acetyltransferase (HAT) and BDNF transcription. The upregulation of IGF1 mimicked the effects of GEE, while IGF1R or HAT inhibition during pregnancy abolished the GEE-induced CaMKIV-dependent histone hyperacetylation and BDNF upregulation. Conclusions These findings suggest that activation of IGF1R/CaMKIV/HAT/BDNF signaling by gestational environment enrichment may serve as a promising strategy to delay AD progression. Electronic supplementary material The online version of this article (10.1186/s40035-019-0149-9) contains supplementary material, which is available to authorized users.

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Responses of serum neurotrophic factors to exercise in pregnant and postpartum women

Cited by 48 publications

References 49 publications

The effect of exercise intensity on brain derived neurotrophic factor and memory in adolescents

The effect of exercise intensity on brain derived neurotrophic factor and memory in adolescents

Beneficial Effects of Maternal Physical Activity during Pregnancy on Fetal, Newborn, and Child Health: Guidelines for Interventions during the Perinatal Period from the French National College of Midwives

Enriched gestation activates the IGF pathway to evoke embryo-adult benefits to prevent Alzheimer’s disease

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