Responses of olfactory receptor neurons in the spiny lobster to binary mixtures are predictable using a noncompetitive model that incorporates excitatory and inhibitory transduction pathways

Daniel, Peter C.; Burgess, Michele; Derby, Charles D.

doi:10.1007/bf00190182

Cited by 22 publications

(7 citation statements)

References 53 publications

(93 reference statements)

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“…However, recent modeling studies involving extracellular recordings from olfactory receptor neurons in the antennules of the spiny lobster have indicated that the components of binary mixtures may be processed independently (Daniel, Burgess, & Derby, 1996;Steullet & Derby, 1997). These results indicate that, at least for mixtures of two single chemical components, the pattern of activity across the population of peripheral neurons is similar to that expected from a combination of the components.…”

supporting

confidence: 58%

The influence of chemical complexity on the perception of multicomponent odor mixtures

Livermore

Laing

1998

Perception & Psychophysics

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The present study investigates the hypothesis that complex object odors (odors that emanate from flowers, foods, sewage, etc.) that consist of dozens of odorants are processed and encoded as discrete entities, as if each was a single chemical odor. To test this hypothesis, the capacity of trained subjects to discriminate and identify the components of stimuli consisting of one to eight object odors was determined. The results indicated that subjects could only identify up to four object odors in a mixture, which is similar to earlier findings with mixtures that contained only single chemical odors. The limited capacity was also reflected in the number of odors selected, regardless of whether the choices were correct or incorrect, in confidence ratings, and in decision times. The identification of a limited number of object odors in every mixture that was presented suggests that both associative (synthetic) and dissociative (analytic) processes are involved in the perceptual analysis of odor mixtures.

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supporting

confidence: 58%

The influence of chemical complexity on the perception of multicomponent odor mixtures

Livermore

Laing

1998

Perception & Psychophysics

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“…As assumed in lobsters (Ache, 1994), such a negative cooperation may be attributed to opposite effects of currents initiated by the two mixture components. Thus, as shown in lobsters and in newts, one odour could counteract the depolarizing current initiated by another excitatory chemical by hyperpolarizing the OSNs (McClintock & Ache, 1989; Michel et al ., 1991; Michel & Ache, 1992, 1994; Kurahashi et al ., 1994; Daniel et al ., 1996; Cromarty & Derby, 1997, 1998). However, given the few inhibitory responses observed in mammalian OSNs in this study, this type of mixture suppression cannot be considered to be preponderant.…”

Section: Discussionmentioning

confidence: 99%

Single olfactory sensory neurons simultaneously integrate the components of an odour mixture

Duchamp‐Viret

Duchamp

Chaput

2003

Eur J of Neuroscience

141

142

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Most odours are complex mixtures. However, the capacities of olfactory sensory neurons (OSNs) to process complex odour stimuli have never been explored in air-breathing vertebrates. To face this issue, the present study compares the electrical responses of single OSNs to two odour molecules, delivered singly and mixed together, in rats in vivo. This work is the first aimed at demonstrating that single OSNs simultaneously integrate several chemical signals and which, furthermore, attempts to describe such processes for the whole concentration range over which single OSNs can work. The results stress that complex interactions occur between components in odour mixtures and that OSN responses to such mixtures are not simply predictable from the responses to their components. Three types of interactions are described. They are termed suppression, hypoadditivity and synergy, in accord with psychophysical terminology. This allows us to draw links between peripheral odour reception and central odour coding. Indeed, events occurring in single OSNs may account for the dominating or even the masking effects of odour molecules in complex mixtures, i.e. for the prevailing action of a minor component in the final qualitative perception of a mixture. We conclude that our observations with binary mixtures anticipate the complexity of processes which may rise at the level of a single OSN in physiological conditions. Following this hypothesis, a natural odour would induce a multi-chemical integration at the level of single OSNs which may result in refining their individual odour-coding properties, leading them to play a crucial role in the final performance of the olfactory system.

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“…ORNs for which one component of a binary mixture is excitatory and the second is either neutral or inhibitory commonly can show mixture suppression (Derby et al, 1989;Ache, 1992, 1994;Daniel et al, 1994Daniel et al, , 1996Kang and Caprio, 1997). Such phenomena have been named mixture interactions (Laing et al, 1984).…”

Section: Discussionmentioning

confidence: 99%

“…The effectiveness of stimuli is assumed to be maximal in our experimental conditions, and this overlap would be limited with natural odor or mixtures, thanks to molecular interactions between components or competition at binding site levels and to the duality of the transduction pathways. Thus, a mixture would have its own unique quality that may arise from these mechanisms (Derby et al, 1989;Daniel et al, 1996).…”

Section: Discussionmentioning

confidence: 99%

Peripheral Odor Coding in the Rat and Frog: Quality and Intensity Specification

2000

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In mammals, two recent studies have shown recently that one odor molecule can be recognized by several molecular olfactory receptors (ORs), and a single OR can recognize multiple odor molecules. In addition, one olfactory receptor neuron (ORN) may respond to different stimuli chosen as representative of distinct odor qualities. The aim of the present study was to analyze quality and intensity coding abilities of rat single ORNs, comparing them with previous extensive data gathered in the frog to get insight into the generality of olfactory coding mechanisms over vertebrates. Response properties of 90 rat ORNs to different odors or to one odor at different concentrations were analyzed. In the rat and the frog, odor quality appears to be specified through the identity of activated ORNs. However, rat ORNs have higher response thresholds. This lower sensitivity may be interpreted as an increase in selectivity of rat ORNs for low or medium odor intensities. In these conditions, the lower proportion of activated ORNs could be counterbalanced by their number, as well as by their higher glomerular convergence ratio in the olfactory bulb. From amphibians to mammals, the olfactory system appears to use universal mechanisms based on a combinatorial-coding mode that may allow quasi-infinite possibilities of adaptation to various olfactory environments.

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Responses of olfactory receptor neurons in the spiny lobster to binary mixtures are predictable using a noncompetitive model that incorporates excitatory and inhibitory transduction pathways

Cited by 22 publications

References 53 publications

The influence of chemical complexity on the perception of multicomponent odor mixtures

The influence of chemical complexity on the perception of multicomponent odor mixtures

Single olfactory sensory neurons simultaneously integrate the components of an odour mixture

Peripheral Odor Coding in the Rat and Frog: Quality and Intensity Specification

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