Responses of neurons of canine area postrema to neurotransmitters and peptides

Abstract

Captain "'Lomas E. Dayton (USAFSAM/RZV) was the Laboratory Project ScienZis-n-Cnarge.-When Government drawing: , pejecifications, or other data are used for any purpose other than in connection with a definitely Government-related procurement, tie United States Government incurs no responsibility or any obligation whatsoever. The fact that the Government may have formulated or in any way supplied the said drawings, specifications, or other data, is not to be regarded by implication, or otherwise in any manner construed, as lIcensing the holder, or any other person or corporation; or as conveying any rights o," permission to manufacture, use, or sell any patented invention that may in at. way be related the-'reto. The animals involved in this study were procured, maintaired, and used in accordance with the Animal Welfare Act and the "Guide for the Care and

Chemotherapy agent cisplatin induces 48-h Fos expression in the brain of a vomiting species, the house musk shrew (Suncus murinus)

“…For example, systemic injection of cisplatin increases plasma levels of substance P and 5-HT (23,41), possibly derived from release of these factors from enteroendocrine cells of the gut. Direct application of 5-HT and substance P can activate neurons in the AP, and intracerebroventricular injection of cisplatin in the cat can produce emesis (11,67).…”

Evidence for a Re-Evaluation of the Neurochemical and Anatomical Bases of Chemotherapy-Induced Vomiting

“…43 Other sources of 5-HT to the dorsal vagal complex region include the medullary raphe nuclei 136 and putative serotonergic cell bodies in the dorsal vagal complex such as the mNTS. 137 Not only are neurons within the AP region excited by 5-HT, 138 but postsynaptic serotonergic receptors (5-HT 1A , 5-HT 2A , 5-HT 3 , Figure 3. Biosynthesis of serotonin.…”

Presynaptically mediated effects of cholecystokinin-8 on the excitability of area postrema neurons in rat brain slices

“…Neurons in the area postrema play an important role in the regulation of feeding behavior (Edwards and Ritter, 1981;Ritter and Edwards, 1984;South and Ritter, 1983). Previous studies have shown the chemosensitivity of area postrema neurons to several kinds of intestine peptide hormones that contribute to the feeding regulation, including CCK, which is known as a hunger suppressant (Carpenter et al, 1983;Funahashi and Adachi, 1993;Sun and Ferguson, 1997). It has been shown that systemic infusion of CCK induced cFos expression in the area postrema, indicates that it is a receptive site for circulating CCK (Luckman et al, 1993).…”