Responses of neurons in nucleus supratrigeminalis to sinusoidal jaw movements in the cat

Miyazaki, Ryoko; Luschei, Erich S.

doi:10.1016/0014-4886(87)90176-2

Cited by 33 publications

(13 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…First, all the afferents intracellularly labeled in this study regularly responded to stretching of the jaw-elevator muscles, which is consistent with that previously reported for jaw-muscle spindle afferents (Appenteng et al, 1978;Inoue et al, 1981;Miyazaki and Luschei, 1987;Donga and Dessem, 1993;Dessem et al, 1997;Kato et al, 1999;Yoshida et al, 1999). Although the afferents responded to muscle stretch in the two basic patterns previously attributed to primary and secondary jawmuscle spindle afferents (Taylor et al, 1992;Dessem et al, 1997), no attempt was made in this study to selectively label individual afferent types.…”

Section: Jaw-muscle Spindle Afferentssupporting

confidence: 77%

“…Although jaw-muscle spindle afferent input to neurons in the supratrigeminal region has previously been reported (Miyazaki and Luschei, 1987;Shigenaga et al, 1988aShigenaga et al, , 1990Yabuta et al, 1996;Dessem et al, 1997;Kishimoto et al, 1998;Yoshida et al, 1999), it has not been shown that Vsup neurons which receive muscle spindle afferent input project to the trigeminal motor nucleus. Due to the close proximity of the Vsup to the HRP injection site, we were unable to clearly distinguish between retrogradely labeled, ipsilateral Vsup neurons and neurons which may have incorporated horseradish peroxidase directly from the injection site.…”

Section: Premotor Neurons Receiving Jaw-muscle Spindle Afferent Inputmentioning

confidence: 95%

“…Thus, we were only able to demonstrate a projection from jaw-muscle spindle afferents to contralateral Vsup premotor neurons. Previous studies (Jerge, 1963;Appenteng et al, 1978;Miyazaki and Luschei, 1987) have reported that neurons in the Vsup can be activated by stretching of the jaw-elevator muscles, a strong stimulus for the activation of muscle spindle afferents. Additional evidence for muscle spindle afferent input to Vsup neurons is provided by reports that these interneurons are activated by palpation of the jaw muscles, stimulation of jaw-muscle nerves, and succinylcholine infusion (Takata and Kawamura, 1970;Gura et al, 1972).…”

Section: Premotor Neurons Receiving Jaw-muscle Spindle Afferent Inputmentioning

confidence: 99%

See 2 more Smart Citations

Jaw‐muscle spindle afferent pathways to the trigeminal motor nucleus in the rat

Luo

Moritani

Dessem

2001

J of Comparative Neurology

View full text Add to dashboard Cite

Neural pathways conveying proprioceptive feedback from the jaw muscles were studied in rats by combining retrograde and intracellular neuronal labeling. Initially, horseradish peroxidase was iontophoresed unilaterally into the trigeminal motor nucleus (Vmo). Two days later, 1-5 jaw-muscle spindle afferent axons located in the mesencephalic trigeminal nucleus were physiologically identified and intracellularly stained with biotinamide. Stained mesencephalic trigeminal jaw-muscle spindle afferent axon collaterals and boutons were predominantly distributed in the supratrigeminal region (Vsup), Vmo, dorsomedial trigeminal principal sensory nucleus (Vpdm), parvicellular reticular formation (PCRt), alpha division of the parvicellular reticular formation (PCRtA), and dorsomedial portions of the spinal trigeminal subnuclei oralis (Vodm), and interpolaris (Vidm). Numerous neurons retrogradely labeled with horseradish peroxidase from the trigeminal motor nucleus were found bilaterally in the PCRt, PCRtA, Vodm, and Vidm. Retrogradely labeled neurons were also present contralaterally in the Vsup, Vpdm, Vmo, peritrigeminal zone, and bilaterally in the dorsal medullary reticular field. Putative contacts between intracellularly stained mesencephalic trigeminal jaw-muscle spindle afferent boutons and trigeminal premotor neurons retrogradely labeled with horseradish peroxidase were found in the ipsilateral Vodm, PCRtA, and PCRt, as well as the contralateral Vsup, Vmo, Vodm, PCRt, and PCRtA. Thus, multiple disynaptic jaw-muscle spindle afferent-motoneuron circuits exist. These pathways are likely to convey long-latency jaw-muscle stretch reflexes and may contribute to stiffness regulation of the masticatory muscles.

show abstract

Section: Jaw-muscle Spindle Afferentssupporting

confidence: 77%

Section: Premotor Neurons Receiving Jaw-muscle Spindle Afferent Inputmentioning

confidence: 95%

Section: Premotor Neurons Receiving Jaw-muscle Spindle Afferent Inputmentioning

confidence: 99%

See 1 more Smart Citation

Jaw‐muscle spindle afferent pathways to the trigeminal motor nucleus in the rat

Luo

Moritani

Dessem

2001

J of Comparative Neurology

View full text Add to dashboard Cite

show abstract

“…Neurons in the supratrigeminal region are important constituents controlling aspects of oral-motor activity because they (1) project to the trigeminal motor nucleus (Mizuno et al, 1983), (2) respond to oral-sensory stimulation (Goldberg and Namamura, 1968;Kidokoro et al, 1968), and (3) are rhythmically active during fictive mastication (Miyazaki and Luschei, 1987;Inoue et al, 1992). Clearly, they are in a unique position to integrate oral-motor sensory information with signals from oral-motor central pattern generators (CPGs).…”

Section: Discussionmentioning

confidence: 98%

Intrinsic membrane properties and morphological characteristics of interneurons in the rat supratrigeminal region

Hsiao

Gougar

Asai

et al. 2007

J of Neuroscience Research

View full text Add to dashboard Cite

The membrane properties and morphological features of interneurons in the supratrigeminal area (SupV) were studied in rat brain slices using whole-cell patch clamp recording techniques. We classified three morphological types of neurons as fusiform, pyramidal, and multipolar and four physiological types of neurons according to their discharge pattern in response to a 1-sec depolarizing current pulse from -80 mV. Single-spike neurons responded with a single spike, phasic neurons showed an initial burst of spikes and were silent during the remainder of the stimulus, delayed-firing (DF) neurons exhibited a slow depolarization and delay to initial spike onset, and tonic (T) neurons showed maintained a discharge throughout the stimulus pulse. In a subpopulation of neurons (10%), membrane depolarization to around -44 mV produced a rhythmic burst discharge (RB) that was associated with voltage-dependent subthreshold membrane oscillations. Both these phenomena were blocked by the sodium channel blocker riluzole at a concentration that did not affect the fast transient spike. Low doses of 4-AP, which blocks low-threshold K+ currents, transformed bursting into low-frequency tonic discharge. In contrast, bursting occurred with exposure to cadium, a calcium-channel blocker. This suggests that persistent sodium currents and low-threshold K+ currents have a role in intrinsic burst generation. Importantly, RB cells were most often associated with multipolar neurons that exhibited either a DF or a T discharge. Thus, the SupV contains a variety of physiological cell types with unique morphologies and discharge characteristics. Intrinsic bursting neurons form a unique group in this region. .

show abstract

“…Neurons in Vsup are known to receive jaw-muscle spindle afferent input (Jerge, 1963;Takata and Kawamura, 1970;Miyazaki and Luschei, 1987;Luo et al, 1991a,b). Several previous studies have described neurons in Vp that respond to jaw movement (Eisenman et al, 1963;Azerad et al, 1982;Ro and Capra, 1994) and could be part of a trigeminothalamic spindle pathway from this region.…”

Section: Discussionmentioning

confidence: 99%

Inputs from identified jaw‐muscle spindle afferents to trigeminothalamic neurons in the rat: A double‐labeling study using retrograde HRP and intracellular biotinamide

Luo

Dessem

1995

J of Comparative Neurology

View full text Add to dashboard Cite

Projections from physiologically identified jaw-muscle spindle afferents onto trigeminothalamic neurons were studied in the rat. Trigeminothalamic neurons were identified by means of retrograde transport of horseradish peroxidase from the ventroposteromedial nucleus of the thalamus. Labeled neurons were found contralaterally in the supratrigeminal region (Vsup), the trigeminal principal sensory nucleus, the ventrolateral part of the trigeminal subnucleus oralis, the spinal trigeminal subnuclei interpolaris and caudalis, the reticular formation, and an area ventral to the trigeminal motor nucleus (Vmo) and medial to the trigeminal principal sensory nucleus (AVM). Jaw-muscle spindle afferents were physiologically identified by their increased firing during stretching of the jaw muscles and intracellularly injected with biotinamide. Axon collaterals and boutons from jaw-muscle spindle afferents were found in Vmo; Vsup; the dorsomedial part of the trigeminal principal sensory nucleus (Vpdm); the dorsomedial part of the spinal trigeminal subnuclei oralis, interpolaris (Vidm) and caudalis; the parvicellular reticular formation (PCRt); and the mesencephalic trigeminal nucleus. Trigeminothalamic neurons in Vsup, Vpdm, Vidm, PCRt, and AVM were associated with axon collaterals and boutons from intracellularly stained jaw-muscle spindle afferents. Trigeminothalamic neurons in Vsup, Vpdm, Vidm, and PCRt were closely apposed by one to 14 intracellularly labeled boutons from jaw-muscle spindle afferents, suggesting a powerful input to some trigeminothalamic neurons. These data demonstrate that muscle length and velocity feedback from jaw-muscle spindle afferents is projected to the contralateral thalamus via multiple regions of the trigeminal system and implicates these pathways in the projection of trigeminal proprioceptive information to the cerebral cortex.

show abstract

Responses of neurons in nucleus supratrigeminalis to sinusoidal jaw movements in the cat

Cited by 33 publications

References 23 publications

Jaw‐muscle spindle afferent pathways to the trigeminal motor nucleus in the rat

Jaw‐muscle spindle afferent pathways to the trigeminal motor nucleus in the rat

Intrinsic membrane properties and morphological characteristics of interneurons in the rat supratrigeminal region

Inputs from identified jaw‐muscle spindle afferents to trigeminothalamic neurons in the rat: A double‐labeling study using retrograde HRP and intracellular biotinamide

Contact Info

Product

Resources

About