Responses of nerve fibers to pulpal inflammation and periapical lesions in rat molars demonstrated by calcitonin gene-related peptide immunocytochemistry

Khayat, Bertrand G.; Byers, Margaret R.; Taylor, Patrick E.; Mecifi, K B; Kimberly, Charles L.

doi:10.1016/s0099-2399(88)80054-2

Cited by 78 publications

(42 citation statements)

References 14 publications

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“…Distribution of CGRP-immunoreactive nerve fibers in the dental pulp of rat molars coincided with that reported in previous literature (HosHINO et al, 1987;KIMBERLY and BYERS, 1988;KHAYAT et al, 1988). CGRPimmunoteactive nerve fibers, beaded in profile, entered the dental pulp through the apical foramen.…”

Section: Light Microscopic Observation Of Cgrp-immunoreactive Nervessupporting

confidence: 89%

“…Accordingly, immunohistochemistry for CGRP has been applied to investigate the neurophysiology of dental pulp, and suggested a possible role of CGRP as a vasoregulator in the dental pulp (UDDMAN et al, 1986;WAKISAKA et al, 1987). Further, dynamic responses of CGRP-immunoreactive nerve fibers to external stimuli including dentinal injury have been demonstrated, suggesting CGRP involvement in tissue repair as well as in sensory and/or vascular regulation KHAYAT et al, 1988;TAYLOR et al, 1988;BYERS et al, 1990 …”

mentioning

confidence: 99%

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Immunoelectron Microscopic Observation of Calcitonin Gene-Related Peptide(CGRP)-positive Nerves in the Dental Pulp of Rat Molars.

Sato

Takeuchi-Maeno

Maeda

et al. 1992

Archives of Histology and Cytology

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Section: Light Microscopic Observation Of Cgrp-immunoreactive Nervessupporting

confidence: 89%

mentioning

confidence: 99%

Immunoelectron Microscopic Observation of Calcitonin Gene-Related Peptide(CGRP)-positive Nerves in the Dental Pulp of Rat Molars.

Sato

Takeuchi-Maeno

Maeda

et al. 1992

Archives of Histology and Cytology

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“…Bazı durumlarda periapikal enflamasyon pulpa tamamen nekroz olmadan başlar, bazı durumlarda ise kök kanalında vital doku varlığına rağmen periapikal radyolusensi görülmesi de olasıdır. 12,13 1. olgu sunumunda kronik travmaya bağlı, 2. olgu sunumunda ise akut diş travmasına bağlı olarak pulpa nekrozu görülmüştür. Her iki vakada da geniş ve birkaç dişi içeren lezyonlar olmasına rağmen tek dişe yapılan kanal tedavisiyle lezyonun iyileşmesi sağlanmıştır.…”

Section: Discussionunclassified

Endodonti̇k Tedavi̇si̇ Yapilmiş Geni̇ş Peri̇api̇kal Lezyonlu Di̇şleri̇n Uzun Dönem Radyografi̇k Taki̇bi̇: 2 Olgu Sunumu

Bayram¹,

Bayram²,

Eren³

2015

Atatürk Üniversitesi Diş Hekimliği Fakültesi Dergisi

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The aim of this paper is to report the healing of two large periapical lesions following non-surgical root canal treatment. The first case was a mandibular right lateral with periapical lesion of endodontic origin in a 40 year-old female patient with extra oral fistula and swelling. In the second case, a mandibular right central incisor was affected in a 22 year-old male patient. The root canals were prepared and filled with calcium hydroxide as an intra-canal medicament. The patients were recalled for clinical evaluation at intervals of 3 weeks. Root canals obturations were performed with gutta-percha and AH Plus sealer. The clinical and radiographic examination after 1 year revealed complete repair. This report confirms that large periapical lesions can respond favourably to nonsurgical treatment.

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“…Sensory nerve fibers play a possible role both in regulating the differentiation and proliferation of pulpal cells during the inflammation or healing processes following pulpal exposure or cavity preparation [1,3,9,10,13]. Sensory denervation showed a significant reduction in dentin formation at the pulp horn [8].…”

Section: Discussionmentioning

confidence: 99%

Immunoelectron Microscopic Study of CGRP-Immunoreactive Nerve Terminals in Wound Healing and Dentin Bridge Formation after Pulpotomy in Rat Molar

Zhang¹,

Fukuyama²,

Zhang

et al. 2003

Acta Histochem. Cytochem

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The purpose of the present study was to investigate the relationship between the neuropeptide calcitonin gene-related peptide-immunoreactive (CGRP-IR) nerves and the differentiation of undifferentiated mesenchymal cells into fibroblast-like cells and odontoblasts during the healing process after a pulpotomy. The first maxillary molars from 56-day-old Wistar rats (n=60) were used. The rats were sacrificed to undergo an immunoelectron microscopic examination at 1, 3, 7, 14, and 28 days, postoperatively. In 1 to 3 postoperative days, numerous unmyelinated degenerated CGRP-IR nerve terminals were observed. In 7 postoperative days, regenerated terminals were found to contain numerous large granular vesicles, small clear vesicles, a few mitochondria and a labeled organelle. Certain terminals were found to be attached with the cell bodies of fibroblast-like cells and their processes at the fibrous matrix layer of the dentin bridge during healing process following a pulpotomy. In 14 to 28 postoperative days, CGRP-IR nerve terminals had come into contact with the differentiating odontoblasts at the odontoblast layer of the dentin bridge. These findings demonstrate strong evidence that CGRP may be related to both the proliferation and cytodifferentiation process as well as to the active function of the renewed odontoblasts in dentin bridge formation.

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Responses of nerve fibers to pulpal inflammation and periapical lesions in rat molars demonstrated by calcitonin gene-related peptide immunocytochemistry

Cited by 78 publications

References 14 publications

Immunoelectron Microscopic Observation of Calcitonin Gene-Related Peptide(CGRP)-positive Nerves in the Dental Pulp of Rat Molars.

Immunoelectron Microscopic Observation of Calcitonin Gene-Related Peptide(CGRP)-positive Nerves in the Dental Pulp of Rat Molars.

Endodonti̇k Tedavi̇si̇ Yapilmiş Geni̇ş Peri̇api̇kal Lezyonlu Di̇şleri̇n Uzun Dönem Radyografi̇k Taki̇bi̇: 2 Olgu Sunumu

Immunoelectron Microscopic Study of CGRP-Immunoreactive Nerve Terminals in Wound Healing and Dentin Bridge Formation after Pulpotomy in Rat Molar

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