Responses of inferior colliculus neurons to harmonic and mistuned complex tones

Sinex, Donal G.; Sabes, Jennifer Henderson; Li, Hongzhe

doi:10.1016/s0378-5955(02)00366-0

Cited by 48 publications

(65 citation statements)

References 37 publications

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“…This speedy registration of inharmonicity is consistent with findings from a recent study by Dyson and Alain (2004), who found an effect of mistuning on auditory evoked potentials as early as 30 ms after sound onset. Evidence from animal studies also suggests that frequency periodicity is already coded in the auditory nerve (Palmer, 1990;Cariani and Delgutte, 1996) and inferior colliculus (Sinex et al, 2002;Sinex et al, 2005). Together, these findings suggest that segregation based on periodicity coding may be taking place in auditory pathways before the primary and/or associative auditory cortices.…”

Section: Discussionmentioning

confidence: 84%

Age-Related Differences in Neuromagnetic Brain Activity Underlying Concurrent Sound Perception

Alain¹,

McDonald²

2007

J. Neurosci.

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Deficits in parsing concurrent auditory events are believed to contribute to older adults' difficulties in understanding speech in adverse listening conditions (e.g., cocktail party). To explore the level at which aging impairs sound segregation, we measured auditory evoked fields (AEFs) using magnetoencephalography while young, middle-aged, and older adults were presented with complex sounds that either had all of their harmonics in tune or had the third harmonic mistuned by 4 or 16% of its original value. During the recording, participants were asked to ignore the stimuli and watch a muted subtitled movie of their choice. For each participant, the AEFs were modeled with a pair of dipoles in the superior temporal plane, and the effects of age and mistuning were examined on the amplitude and latency of the resulting source waveforms. Mistuned stimuli generated an early positivity (60 -100 ms), an object-related negativity (ORN) (140 -180 ms) that overlapped the N1 and P2 waves, and a positive displacement that peaked at ϳ230 ms (P230) after sound onset. The early mistuning-related enhancement was similar in all three age groups, whereas the subsequent modulations (ORN and P230) were reduced in older adults. These age differences in auditory cortical activity were associated with a reduced likelihood of hearing two sounds as a function of mistuning. The results reveal that inharmonicity is rapidly and automatically registered in all three age groups but that the perception of concurrent sounds declines with age.

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Section: Discussionmentioning

confidence: 84%

Age-Related Differences in Neuromagnetic Brain Activity Underlying Concurrent Sound Perception

Alain¹,

McDonald²

2007

J. Neurosci.

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“…A single harmonic tone was generated by summing the first 8 harmonics of 250 Hz. A mistuned tone was produced by shifting the frequency of a single component by 3-12% (Sinex et al 2002(Sinex et al , 2003Sinex 2005). A double harmonic tone was generated by summing the waveforms of two single harmonic tones with different f0s (Sinex and Li in press).…”

Section: Stimulimentioning

confidence: 99%

“…The 220-Hz component likely was produced by interactions between responses synchronized to Component 5, at 1250 Hz, and the mistuned Component 4, at 1030 Hz. The component at 30 Hz could be produced if response components at 220 and 250 Hz interact; we have previously referred to interactions of this type as second-order envelopes when describing the responses of IC neurons to mistuned tones (Sinex et al 2002. As in Fig.…”

Section: Representation Of Mistuned Tonesmentioning

confidence: 99%

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Responses of cochlear nucleus neurons to harmonic and mistuned complex tones

Sinex

2008

Hearing Research

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Preliminary measurements of the representation in the cochlear nucleus (CN) of harmonic tones, harmonic tones with mistuned components, and double harmonic tones are reported. These data indicate that, unlike auditory nerve fibers and IC neurons, neurons in the CN may exhibit one of several qualitatively-different response patterns when stimulated with mistuned tones. Primarylike neurons synchronized their discharges to 2-3 individual stimulus components, much like auditory nerve fibers do. Chopper neurons tended to respond with the periodicity of envelopes produced by interactions between adjacent stimulus components but exhibited little or no response synchronized to individual stimulus components. A small proportion of CN neurons exhibited complex slowlymodulated discharge patterns similar to those that are commonly observed in the inferior colliculus (IC). The patterns obtained from CN neurons with different pure-tone discharge patterns were generally consistent with expectations based on previous studies with other stimuli. The measurements provided additional insight into the hierarchical processing stages that result in the highly patterned responses of IC neurons to harmonic and mistuned tones.

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“…Neurophysiological research provides evidence that such envelope modulations are available in the auditory nerve [11], cochlear nucleus [10] and inferior colliculus [12] of chinchillas, the temporal discharge pattern of a single unit neuron stimulated by mistuned components were modulated by interactions between adjacent components. Mul- tiunit activity recordings from Monkey's primary auditory cortex also reflect "beats" in the stimuli generated by the interactions between a mistuned component and adjacent components [1].…”

Section: Introductionmentioning

confidence: 99%

Possible role of cochlear nonlinearity in the detection of mistuning of a harmonic component in a harmonic complex

Stoelinga

Heo

Lee

et al. 2015

AIP Conference Proceedings

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Abstract. The human auditory system has a remarkable ability to "hear out" a wanted sound (target) in the background of unwanted sounds. One important property of sound which helps us hear-out the target is inharmonicity. When a single harmonic component of a harmonic complex is slightly mistuned, that component is heard to separate from the rest. At high harmonic numbers, where components are unresolved, the harmonic segregation effect is thought to result from detection of modulation of the time envelope (roughness cue) resulting from the mistuning. Neurophysiological research provides evidence that such envelope modulations are represented early in the auditory system, at the level of the auditory nerve. When the mistuned harmonic is a low harmonic, where components are resolved, the harmonic segregation is attributed to more centrally-located auditory processes, leading harmonic components to form a perceptual group heard separately from the mistuned component. Here we consider an alternative explanation that attributes the harmonic segregation to detection of modulation when both high and low harmonic numbers are mistuned. Specifically, we evaluate the possibility that distortion products in the cochlea generated by the mistuned component introduce detectable beating patterns for both high and low harmonic numbers. Distortion product otoacoustic emissions (DPOAEs) were measured using 3, 7, or 12-tone harmonic complexes with a fundamental frequency (F0) of 200 or 400 Hz. One of two harmonic components was mistuned at each F0: one when harmonics are expected to be resulted and the other from unresolved harmonics. Many non-harmonic DPOAEs are present whenever a harmonic component is mistuned. These non-harmonic DPOAEs are often separated by the amount of the mistuning (ΔF). This small frequency difference will generate a slow beating pattern at ΔF, because this beating is only present when a harmonic component is mistuned, it could provide a cue for behavioral detection of harmonic complex mistuning and may also be associated with the modulation of auditory nerve responses.

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Responses of inferior colliculus neurons to harmonic and mistuned complex tones

Cited by 48 publications

References 37 publications

Age-Related Differences in Neuromagnetic Brain Activity Underlying Concurrent Sound Perception

Age-Related Differences in Neuromagnetic Brain Activity Underlying Concurrent Sound Perception

Responses of cochlear nucleus neurons to harmonic and mistuned complex tones

Possible role of cochlear nonlinearity in the detection of mistuning of a harmonic component in a harmonic complex

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