Responses of hepatic biochemical markers in bream Abramis brama L. to dietary administered polychlorinated biphenyls

Abstract

An experimental study of the effects of dietary administered polychlorinated biphenyls (PCBs) on bream (Abramis brama L.) is reported in the present article. Responses of xenobiotic biotransformation sys tem (ethoxyresorufin O deethylase and glutathione S transferase activities), antioxidant system (superox ide dismutase and catalase activities), and lipid peroxidation system (levels of conjugated dienes and malonic dialdehyde) are investigated. A PCB dose of 2 mg/kg feed does not cause irreversible physiological transfor mations in bream after 14 days of administration. The defense systems appear to efficiently suppress the effects of the xenobiotic and maintain stable and low intensity of the destructive processes at the exposure conditions used.

The Action of Cox/Lox Inhibitors on Antioxidant System and Morphological State of Rat’s Colon Mucosa Under the Conditions of Stress

“…Lipids of cell and mitochondrial membranes are the most sensitive molecules to free radical oxidation [14]. The final product of their chemical transformation is malonic dialdehyde, which can bind with thiobarbituric acid (TBA) [15]. The contraction to the lipid peroxidation is provided by the antioxidant enzymes -superoxide dismutase (SOD), catalase, glutathione peroxidase [16] and in some way by myeloperoxidase (MPO), which transforms hydrogen peroxide by neutrophils, and is also a marker of neutrophil infiltration [17].…”