Responses of Dogs to Hypothermia

Ventricular Function After Hypothermic Cardiac Arrest

“…This oxygen need of the myocardium may be still further reduced by hypothermia,4 which reduces the oxygen needs of most body tissues. 1,19 Since profound hypothermia of itself will cause cardiac arrest, it is natural that a variety of hypothermic techniques have been employed to secure a quiet, bloodless heart for experimental or clinical open cardiac surgery. There has been no definitive study of the relative advantages of these tech¬ niques, which vary from stopping the heart by perfusion of the coronary arteries with cold blood, to arrest achieved by profound total-body hypothermia.…”

Oxygen Consumption of Hyper- and Hypothermic Premature Infants

“…Adolph (1950), Bigelow et aL. (1950), Horvath et al (1953 and Spurr et al (1954) used deep anaesthesia for this purpose. We have used either hypothalamic lesions in adult rats or local heating of the thermoregulatory region of the hypothalamus in adult cats (Mestyain et al, 1959a;, but the animals in question were then examined in the absence of anaesthesia.…”

“…Although the changes in 02 consumption in homeothermic animals with impaired thermoregulation have usually been attributed to the consequential changes in body temperature, and although the Qlo so derived was 2-3 (Adolph, 1950;Bigelow, Lindsay, Harrison, Gordon and Greenwood, 1950;Horvath, Hutt, Spurr and Stevens, 1953;Spurr, Hutt and Horvath, 1954;Thauer, 1955;Behmann and Bontke, 1958), there are exceptions. Thus Balogh, Donhoffer, Mestyain, Pap and T6th (1952), Donhoffer, Mestyan, Obrincsaik-Pap, Pap and Toth (1953), and Donhoffer, Mestyan, Nagy and Szegvari (1957) found that the rise in 02 consumption of hyperthermic rats was not directly related to the increase in body temperature.…”