Responses of biomarkers belonging to different metabolic systems of rats following oral administration of aluminium nanoparticle

Canli, Esin G.; İla, Hasan Basri; Canli, Mustafa

doi:10.1016/j.etap.2019.04.002

Cited by 23 publications

(13 citation statements)

References 40 publications

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“…Moreover, oxidative stress was observed in several organs of rodents following acute and repeated intraperitoneal exposure [44,48]. Using doses of Al 2 O 3 NMs more consistent with daily human exposure (0.5 to 70 mg/kg bw), oxidative stress was detected in rat liver, kidney and erythrocytes after repeated daily oral exposure [39,45,49]. In vitro, some evidence that exposure to Al 2 O 3 NMs can induce oxidative stress has been also reported in various cell lines following 24 h exposure [18,33,44,46,47] that can be rapidly repaired depending on the concentration [47].…”

Section: Discussionmentioning

confidence: 99%

Genotoxicity of Aluminum and Aluminum Oxide Nanomaterials in Rats Following Oral Exposure

et al. 2020

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Due to several gaps remaining in the toxicological evaluation of nanomaterials (NMs), consumers and public health agencies have shown increasing concern for human health protection. In addition to aluminum (Al) microparticles, Al-containing nanomaterials (Al NMs) have been applied by food industry as additives and contact materials. Due to the limited amount of literature on the toxicity of Al NMs, this study aimed to evaluate the in vivo genotoxic potential of Al 0 and Al 2 O 3 NMs after acute oral exposure. Male Sprague-Dawley rats were administered three successive gavages at 6, 12.5 and 25 mg/kg bw. A comparison with AlCl 3 was done in order to assess the potential effect of dissolution into Al ions. Both DNA strand breaks and oxidative DNA damage were investigated in six organs/tissues (duodenum, liver, kidney, spleen, blood and bone marrow) with the alkaline and the Fpg-modified comet assays. Concomitantly, chromosomal damage was investigated in bone marrow and colon with the micronucleus assay. The comet assay only showed DNA damage with Al 2 O 3 NMs in bone marrow (BM), while AlCl 3 induced slight but non-significant oxidative DNA damage in blood. No increase of chromosomal mutations was observed after treatment with the two Al MNs either in the BM or in the colons of rats.

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Section: Discussionmentioning

confidence: 99%

Genotoxicity of Aluminum and Aluminum Oxide Nanomaterials in Rats Following Oral Exposure

et al. 2020

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“…At the cellular level, nanomaterials can affect normal cells through cytotoxicity [83], genotoxicity [84], or genetic regulation [85]. At the tissue level, different nanomaterials have different metabolic modes [86]. Moreover, they will accumulate in specific tissues and organs to produce toxicity.…”

Section: Discussionmentioning

confidence: 99%

Applications of Nanomaterials for Theranostics of Melanoma

Jin

Cheah

et al. 2020

JNT

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Melanoma is an aggressive form of skin cancer with a very high mortality rate. Early diagnosis of the disease, the utilization of more potent pharmacological agents, and more effective drug delivery systems are essential to achieve an optimal treatment plan. The applications of nanotechnology to improve therapeutic efficacy and early diagnosis for melanoma treatment have received great interest among researchers and clinicians. In this review, we summarize the recent progress of utilizing various nanomaterials for theranostics of melanoma. The key importance of using nanomaterials for theranostics of melanoma is to improve efficacy and reduce side effects, ensuring safe implementation in clinical use. As opposed to conventional in vitro diagnostic methods, in vivo medical imaging technologies have the advantages of being a type of non-invasive, real-time monitoring. Several common nanoparticles, including ultrasmall superparamagnetic iron oxide nanoparticles, silica nanoparticles, and carbon-based nanoparticles, have been applied to deliver chemotherapeutic agents for the theranostics of melanoma. The application of nanomaterials for theranostics in molecular imaging (MRI, PET, US, OI, etc.) plays an important role in targeting drug delivery of melanoma, by monitoring the distribution site of the molecular imaging probe and the therapeutic drug in the body in real-time. Hence, it is worthwhile to anticipate the approval of these nanomaterials for theranostics in molecular imaging by the US Food and Drug Administration in clinical trials.

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“…With their steady increase in output, it was expected that by 2020, the production of AlNPs would exceed 100,000 tons (Asztemborska, 2018). AlNPs are employed in a variety of applications, including food, agriculture, engineering, industry, pharmacy, medicine and others (Alshatwi et al, 2013;Canli et al, 2019b;Yousef et al, 2019b). AlNPs are used in heat transfer fluids, modification of polymers, and treatment of sewage.…”

Section: Introductionmentioning

confidence: 99%

Potential Toxic Effects of Aluminum Nanoparticles: An overview

Elkhadrawy¹,

Abou-Zeid²,

El-Borai³

et al. 2021

Journal of Current Veterinary Research

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Alumina (aluminum oxide) nanoparticles (AlNPs) have been categorized among the most important nano-metals, with wide applications in many fields as in food, agriculture, industry, engineering, pharmacy, medicine and others. The extensive use of AlNPs results in a massive release of them into the environment resulting in potential adverse impacts on animals and human health. Toxicokinetic studies demonstrated the rapid absorption and the systemic distribution of AlNPs to different organs. AlNPs mainly induced their toxic damage by induction of oxidative stress and mitochondrial dysfunction. Cellular accumulation of AlNPs resulted in interaction with cell components and binding with proteins and genetic materials (DNA and RNA) with producing other different chemical compounds resulting in cellular oxidative damage. Also, AlNPs induced cell death by disrupting the integrity of the mitochondrial membrane, depleting the mitochondrial thiols, activating apoptotic caspases (9 and 3) and generating more ROS. Previous in vivo and in vitro studies revealed hepato-, nephro-, myocardial, reproductive and neuro-toxic effects of AlNPs. Moreover, AlNPs exert inflammatory, apoptotic and geno-toxic effects. The aim here is to spot on previous studies demonstrating the toxic effects of AlNPs.

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Responses of biomarkers belonging to different metabolic systems of rats following oral administration of aluminium nanoparticle

Cited by 23 publications

References 40 publications

Genotoxicity of Aluminum and Aluminum Oxide Nanomaterials in Rats Following Oral Exposure

Genotoxicity of Aluminum and Aluminum Oxide Nanomaterials in Rats Following Oral Exposure

Applications of Nanomaterials for Theranostics of Melanoma

Potential Toxic Effects of Aluminum Nanoparticles: An overview

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