Responses of auditory nerve fibers to harmonic and mistuned complex tones

Sinex, Donal G.; Guzik, Heidi; Li, Hongzhe; Sabes, Jennifer Henderson

doi:10.1016/s0378-5955(03)00189-8

Cited by 35 publications

(37 citation statements)

References 28 publications

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“…10B) and normalized spike rate variations (Fig. 10C) would be analogous to F 0 amplitude and VS, respectively (Goldberg and Brown 1969;Young and Sachs 1979;Sachs and Young 1979;Sinex et al 2003). In fact, the trends with modeled level are consistent with the trends observed in the plots of Figures 3, 6, and 7.…”

Section: Modeled Responses To Sam Trainssupporting

confidence: 68%

“…Efficacy of VS and F 0 amplitude for assessing ANF responses to SAM pulse trains VS is a measure normalized to average discharge rate which has been widely used for assessing stimulussynchronized temporal discharge patterns throughout the auditory system (Goldberg and Brown 1969;Young and Sachs 1979;Sachs and Young 1979;Sinex et al 2003;Middlebrooks 2008). The measure of F 0 amplitude reflects the degree to which absolute spike rate variations follow the amplitude of the modulated stimulus.…”

Section: Modeled Responses To Sam Trainsmentioning

confidence: 99%

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Changes in Auditory Nerve Responses Across the Duration of Sinusoidally Amplitude-Modulated Electric Pulse-Train Stimuli

Miller

Abbas

et al. 2010

JARO

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Response rates of auditory nerve fibers (ANFs) to electric pulse trains change over time, reflecting substantial spike-rate adaptation that depends on stimulus parameters. We hypothesize that adaptation affects the representation of amplitude-modulated pulse trains used by cochlear prostheses to transmit speech information to the auditory system. We recorded cat ANF responses to sinusoidally amplitude-modulated (SAM) trains with 5,000 pulse/s carriers. Stimuli delivered by a monopolar intracochlear electrode had fixed modulation frequency (100 Hz) and depth (10%). ANF responses were assessed by spike-rate measures, while representation of modulation was evaluated by vector strength (VS) and the fundamental component of the fast Fourier transform (F 0 amplitude). These measures were assessed across the 400 ms duration of pulse-train stimuli, a duration relevant to speech stimuli. Different stimulus levels were explored and responses were categorized into four spike-rate groups to assess level effects across ANFs. The temporal pattern of rate adaptation to modulated trains was similar to that of unmodulated trains, but with less rate adaptation. VS to the modulator increased over time and tended to saturate at lower spike rates, while F 0 amplitude typically decreased over time for low driven rates and increased for higher driven rates. VS at moderate and high spike rates and degree of F 0 amplitude temporal changes at low and moderate spike rates were positively correlated with the degree of rate adaptation. Thus, high-rate carriers will modify the ANF representation of the modulator over time. As the VS and F 0 measures were sensitive to adaptation-related changes over different spike-rate ranges, there is value in assessing both measures.

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Section: Modeled Responses To Sam Trainssupporting

confidence: 68%

Section: Modeled Responses To Sam Trainsmentioning

confidence: 99%

Changes in Auditory Nerve Responses Across the Duration of Sinusoidally Amplitude-Modulated Electric Pulse-Train Stimuli

Miller

Abbas

et al. 2010

JARO

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“…We have previously studied the representation of harmonic and mistuned tones in the auditory nerve and the inferior colliculus (IC) of the chinchilla (Sinex et al 2002(Sinex et al , 2003Sinex 2005). We have also described the representation of pairs of harmonic tones with different fundamental frequencies in the IC (Sinex and Li in press).…”

Section: Introductionmentioning

confidence: 99%

“…In contrast, at the level of the auditory nerve, there is no qualitative difference between the representation of a purely-harmonic tone, and a tone with a mistuned component. Auditory nerve fibers represent individual components in the spectra of complex sounds in discharge synchrony (Sinex et al 2003). The particular stimulus components that are represented in the response do not depend on whether components are harmonically related.…”

Section: Introductionmentioning

confidence: 99%

Responses of cochlear nucleus neurons to harmonic and mistuned complex tones

Sinex

2008

Hearing Research

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Preliminary measurements of the representation in the cochlear nucleus (CN) of harmonic tones, harmonic tones with mistuned components, and double harmonic tones are reported. These data indicate that, unlike auditory nerve fibers and IC neurons, neurons in the CN may exhibit one of several qualitatively-different response patterns when stimulated with mistuned tones. Primarylike neurons synchronized their discharges to 2-3 individual stimulus components, much like auditory nerve fibers do. Chopper neurons tended to respond with the periodicity of envelopes produced by interactions between adjacent stimulus components but exhibited little or no response synchronized to individual stimulus components. A small proportion of CN neurons exhibited complex slowlymodulated discharge patterns similar to those that are commonly observed in the inferior colliculus (IC). The patterns obtained from CN neurons with different pure-tone discharge patterns were generally consistent with expectations based on previous studies with other stimuli. The measurements provided additional insight into the hierarchical processing stages that result in the highly patterned responses of IC neurons to harmonic and mistuned tones.

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“…Neurophysiological research provides evidence that such envelope modulations are available in the auditory nerve [11], cochlear nucleus [10] and inferior colliculus [12] of chinchillas, the temporal discharge pattern of a single unit neuron stimulated by mistuned components were modulated by interactions between adjacent components. Mul- tiunit activity recordings from Monkey's primary auditory cortex also reflect "beats" in the stimuli generated by the interactions between a mistuned component and adjacent components [1].…”

Section: Introductionmentioning

confidence: 99%

Possible role of cochlear nonlinearity in the detection of mistuning of a harmonic component in a harmonic complex

Stoelinga

Heo

Lee

et al. 2015

AIP Conference Proceedings

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Abstract. The human auditory system has a remarkable ability to "hear out" a wanted sound (target) in the background of unwanted sounds. One important property of sound which helps us hear-out the target is inharmonicity. When a single harmonic component of a harmonic complex is slightly mistuned, that component is heard to separate from the rest. At high harmonic numbers, where components are unresolved, the harmonic segregation effect is thought to result from detection of modulation of the time envelope (roughness cue) resulting from the mistuning. Neurophysiological research provides evidence that such envelope modulations are represented early in the auditory system, at the level of the auditory nerve. When the mistuned harmonic is a low harmonic, where components are resolved, the harmonic segregation is attributed to more centrally-located auditory processes, leading harmonic components to form a perceptual group heard separately from the mistuned component. Here we consider an alternative explanation that attributes the harmonic segregation to detection of modulation when both high and low harmonic numbers are mistuned. Specifically, we evaluate the possibility that distortion products in the cochlea generated by the mistuned component introduce detectable beating patterns for both high and low harmonic numbers. Distortion product otoacoustic emissions (DPOAEs) were measured using 3, 7, or 12-tone harmonic complexes with a fundamental frequency (F0) of 200 or 400 Hz. One of two harmonic components was mistuned at each F0: one when harmonics are expected to be resulted and the other from unresolved harmonics. Many non-harmonic DPOAEs are present whenever a harmonic component is mistuned. These non-harmonic DPOAEs are often separated by the amount of the mistuning (ΔF). This small frequency difference will generate a slow beating pattern at ΔF, because this beating is only present when a harmonic component is mistuned, it could provide a cue for behavioral detection of harmonic complex mistuning and may also be associated with the modulation of auditory nerve responses.

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Responses of auditory nerve fibers to harmonic and mistuned complex tones

Cited by 35 publications

References 28 publications

Changes in Auditory Nerve Responses Across the Duration of Sinusoidally Amplitude-Modulated Electric Pulse-Train Stimuli

Changes in Auditory Nerve Responses Across the Duration of Sinusoidally Amplitude-Modulated Electric Pulse-Train Stimuli

Responses of cochlear nucleus neurons to harmonic and mistuned complex tones

Possible role of cochlear nonlinearity in the detection of mistuning of a harmonic component in a harmonic complex

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