We investigate the Higgs-Yukawa system with Majorana masses of a fermion within asymptotically safe quantum gravity. Using the functional renormalization group method we derive the beta functions of the Majorana masses and the Yukawa coupling constant and discuss the possibility of a non-trivial fixed point for the Yukawa coupling constant. In the gravitational sector we take into account higher derivative terms such as R 2 and Rµν R µν in addition to the Einstein-Hilbert term for our truncation. For a certain value of the gravitational coupling constants and the Majorana masses, the Yukawa coupling constant has a non-trivial fixed point value and becomes an irrelevant parameter being thus a prediction of the theory. We also discuss consequences due to the Majorana mass terms to the running of the quartic coupling constant in the scalar sector. * Electronic address: gpbrito@cbpf.br † Electronic address: yhamada@physics.uoc.gr ‡ Electronic address: adpjunior@id.uff.br § Electronic address: m.yamada@thphys.uni-heidelberg.de scale k. Several subsequent works, employing more sophisticated approximations provided compelling support for the existence of such the Reuter fixed point, see, e.g., . Remarkably, the existence of the UV fixed point has shown to be preserved against the introduction of Standard Model (SM) matter degrees of freedom, hinting to a fundamental theory of quantum gravity which is compatible with the observed SM particles, see [9,. Moreover, many different works have provided evidence for a saturation on the number of relevant directions associated to the Reuter fixed point, ensuring thus, predictivity [30,31,35,38,42,44,45,49,50,67,[79][80][81]. This underpins the quest for a quantum theory of gravity by using continuum quantum field theory methods.Within the asymptotic safety scenario, coupling matter degrees of freedom to (quantum) gravity is straightforward. This allows for a rich interplay between the effects of matter fluctuations into gravitational running couplings and the reverse. In particular, this opens the possibility to test whether quantum gravitational effects allow for the resolution of long-standing problems as, e.g., the triviality problem in the SM, see [82][83][84]. Having a fundamental theory of gravity and matter valid up to arbitrarily short distances also leads to an enhancement of predictivity. In fact, the fixed point structure as well as the assumption that the SM holds up all the way until the Planck scale leads to a prediction of the Higgs mass to be m H = 126 GeV for the top quark mass m t = 171 GeV, see [78,85]. This happens thanks to its quantum-gravity induced irrelevance, being thus a prediction and not a free parameter of the theory. Recent works [84,86,87] have managed to successfully explain observed quantities in the low energy regimes by assuming the existence of the asymptotically safe fixed point for gravity-matter systems. Furthermore, asymptotically safe quantum gravity might be able to provide solutions for important problems in both particle physics and c...