Responses and functions of dopamine in nucleus accumbens core during social behaviors

Dai, Bing; Sun, Fangmiao; Tong, Xiaoyu; Ding, Yizhuo; Kuang, Amy; Osakada, Takuya; Li, Yulong; Lin, Dayu

doi:10.1016/j.celrep.2022.111246

Cited by 86 publications

(54 citation statements)

References 102 publications

(125 reference statements)

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“…Across species, dopamine plays an important role in navigating social relationships. Dopamine is released in the nucleus accumbens during social interaction, and manipulations that increase or decrease dopaminergic system activity within this region promote or impair social interactions, respectively ( 1 – 3 ). Yet studies to date have examined realtime dopamine dynamics exclusively in laboratory mice ( 1, 2 ) and rats ( 4 ), species that exhibit affiliation but do not form selective attachments.…”

Section: Introductionmentioning

confidence: 99%

Nucleus accumbens dopamine release reflects the selective nature of pair bonds

Pierce

Protter

Chapel

et al. 2022

Preprint

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In monogamous species, prosocial behaviors directed towards partners are dramatically different from those directed towards unknown individuals and potential threats. Dopamine release in the nucleus accumbens plays an important role in guiding social behavior, however, its role in real time social decision making in a monogamous species remains largely unknown. We used monogamous prairie voles to investigate how dopamine release differs in voles when seeking and interacting with a pair bonded partner or a novel vole. Employing the sub-second temporal resolution of the fluorescent biosensor, GRABDA, during a social operant task, we found that partner seeking, anticipation, and interaction resulted in more dopamine release than the same events directed towards a novel vole. Furthermore, partner-elicited dopamine release decreases after prolonged partner separation. Thus, differences in partner- and novel-elicited dopamine release reflect the selective nature of pair bonds and may drive the social behaviors that reinforce and cement bonds over time, eroding after partner loss to facilitate new bond formation.

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Section: Introductionmentioning

confidence: 99%

Nucleus accumbens dopamine release reflects the selective nature of pair bonds

Pierce

Protter

Chapel

et al. 2022

Preprint

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“…Here, we found the MeA Esr1 cells were rapidly and specifically activated during social investigation, especially towards females, but not object investigation, suggesting a potential social-specific role. Interestingly, in comparison to MeAp, MeAa projects more densely to the ventral striatum and ventral tegmental area, regions essential for moment-to-moment social interest (Dai et al, 2022;Gunaydin et al, 2014;Pardo-Bellver et al, 2012).…”

Section: The Overall Activation Pattern In the Expanded Sbn During Ma...mentioning

confidence: 99%

Neural dynamics in the limbic system during male social behaviors

Guo

Yin

Osakada

et al. 2023

Preprint

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Sexual and aggressive behaviors are two evolutionarily conserved social behaviors vital for an animal's survival and reproductive success. While an increasing number of brain regions in the limbic system have been identified as functionally relevant for these two types of behaviors, an understanding of how social cues are represented across brain regions and how social behaviors are generated via this network activity remains elusive. To gain a holistic view of the neural responses during social behaviors, we utilized multi-fiber photometry to simultaneously record Ca2+ signals of estrogen receptor alpha (Esr1)-expressing cells from 13 limbic brain regions in male mice during sexual and aggressive behaviors and compare the response magnitude and temporal patterns across regions. We find that conspecific sensory information, as well as social action initiation signals, are widely distributed in the limbic system and can be decoded from the network activity. Cross-region correlation analysis reveals striking increases in functional connectivity in the network during the action initiation phase of social behaviors whereas advanced copulation is accompanied by a "dissociated" network state. Based on the response patterns, we propose a mating-biased network (MBN) and an aggression-biased network (ABN) for mediating male sexual and aggressive behaviors, respectively.

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“…Dai et al used fiberoptic photometry to measure overall neuronal signaling levels (Dai et al, 2022; Nazempour et al, 2021; Sych et al, 2019); they examined DA responses and function in the nucleus accumbens during the approach, investigatory, and consummatory phases of several social behaviors. Zhu et al used single/multiphoton imaging at the individual neuron level (Bovetti et al, 2014; Zhang, Hernandez, et al, 2019; Zhang, Xiao, et al, 2019; Zhu et al, 2020) to demonstrate that Ach and monoamine diffuse within a single release site in the striatum.…”

Section: Biosensorsmentioning

confidence: 99%

“…Second, they can be used to achieve specific selective long-term expression in cells with anatomical junctions or unique molecular properties. Genetically encoded sensors can be used in combination with optical techniques to record freely moving and waking animals over the course of 2 weeks or longer after initial viral delivery of genes encoding the sensors; transgenic manipulation of animals even allows permanent expression (and therefore permanent capacity for measurement).Dai et al used fiberoptic photometry to measure overall neuronal signaling levels(Dai et al, 2022;Nazempour et al, 2021;Sych et al, 2019); they examined DA responses and function in the nucleus accumbens during the approach, investigatory, and consummatory phases of several social behaviors. Zhu et al used single/multiphoton imaging at the individual neuron level(Bovetti et al, 2014;Zhang, Hernandez, et al, 2019;Zhang, Xiao, et al, 2019;Zhu et al, 2020) toF I G U R E 3 (a,b) Representative design scaffolds (top) and cartoons showing neurotransmitter indicators based on (a) bacterial periplasmic binding protein (PBP) and (b) cognate G-protein-coupled receptor (GPCR).…”

mentioning

confidence: 99%

Analytical strategies in neurotransmitter measurements: A mini literature review

Zhu

Liu

Chen

et al. 2022

Biomedical Chromatography

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Neurotransmitters (NTs) are endogenous, polar, low‐molecular‐weight compounds that play multiple pivotal roles in the central nervous system. NTs are involved in communicating information, responding to stress, regulating motor coordination, and allowing interneuronal communication in living organisms. It is essential to determine the distribution of NTs in brain regions to better understand drug dependence and abuse, neurological disorders, psychological disorders, and aging. Monitoring NT levels is also important in diagnosing and avoiding serious illnesses. We here review chromatography‐based analytical techniques, including pretreatment methods (e.g., microdialysis and solid‐phase microextraction), as well as detection strategies (e.g., MS and electrochemistry), focusing on developments in these techniques over the past 5 years. We then highlight recent advances in electrochemical and fluorescence imaging methods in vivo and the disadvantages and advantages of such technologies, including high spatiotemporal resolution, polymer specificity, and high sensitivity. Finally, we summarize and compare the complementary advantages of chromatography‐based analytical techniques and biosensors and discuss trends in the development of NT detection technologies.

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Responses and functions of dopamine in nucleus accumbens core during social behaviors

Cited by 86 publications

References 102 publications

Nucleus accumbens dopamine release reflects the selective nature of pair bonds

Nucleus accumbens dopamine release reflects the selective nature of pair bonds

Neural dynamics in the limbic system during male social behaviors

Analytical strategies in neurotransmitter measurements: A mini literature review

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