Response to “Unusually low plasma concentrations of lipopolysaccharide following 160-km race”

Davis, J. Mark; Nieman, David C.; Murphy, E. Angela

doi:10.1016/j.bbi.2007.03.003

Cited by 3 publications

(2 citation statements)

References 5 publications

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“…In animals, Kupffer cells are a major source of circulating TNF-a after LPS challenge (16), making the liver a possible source of fhe running-specific increase in TNF-a. However, TNF-a concentrations are unchanged after a triathlon despite increased LPS (15), while even fhe presence of increased LPS concentrations during exereise in humans remains contentious (7).…”

Section: Discussionmentioning

confidence: 99%

Effect of Exercise Intensity on the Cytokine Response to an Acute Bout of Running

Scott

Sale

Greeves³

et al. 2011

Medicine &Amp; Science in Sports &Amp; Exercise

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Section: Discussionmentioning

confidence: 99%

Effect of Exercise Intensity on the Cytokine Response to an Acute Bout of Running

Scott

Sale

Greeves³

et al. 2011

Medicine &Amp; Science in Sports &Amp; Exercise

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“…62 Doubts exist concerning the specificity of laboratory methods used to measure plasma lipopolysaccharide concentration. 63…”

Section: Exercise Heat Stress and Immune Cell Functionmentioning

confidence: 99%

Heat, Athletes, and Immunity

Peake

2010

American Journal of Lifestyle Medicine

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During exercise, body temperature rises as a result of increased energy metabolism and heat absorbed from the environment. In response to this rise in body temperature, blood flow increases and stress hormones are released. Together, blood flow and stress hormones stimulate increases in the number of circulating leukocytes and alterations in various aspects of immune function, including cytokine production. The extent of changes in leukocyte numbers, cytokine concentrations, and immune cell function depends on how high body temperature rises and the intensity and duration of exercise. In general, increases in body temperature of ≤ 1.8° F (1° C) induce mild changes in immune function, and such changes are unlikely to increase the risk of illness in athletes, firefighters, and military personnel who regularly exercise in hot conditions. More severe immune disturbances during exercise in extreme heat (≥ 106° F or 41° C) may contribute to classical symptoms of heatstroke.

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Cytokine response to acute running in recreationally-active and endurance-trained men

Scott

Sale

Greeves³

et al. 2013

Eur J Appl Physiol

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To compare the cytokine response to exhaustive running in recreationally-active (RA) and endurance-trained (ET) men. Eleven RA men (VO2max 55 ± 7 mL·min(-1)·kg(-1)) and 10 ET men (VO₂max 68 ± 7 mL·min(-1)·kg(-1)) followed a controlled diet and refrained from volitional exercise for 8 days. On the fourth day, participants completed 60 min of treadmill running (65 % VO₂max), followed by intermittent running to exhaustion (70 % VO₂max). Fasting blood was obtained at baseline, after 20, 40 and 60 min of exercise, at the end of intermittent exercise, during 2 h of recovery and on four follow-up days (FU1-FU4). Tumour necrosis factor-alpha (TNF-α), interleukin-1β (IL-1β), interleukin-6 (IL-6), interleukin-1 receptor antagonist (IL-1ra) and creatine kinase (CK) were measured. Exercise increased the concentrations of all cytokines and CK, but there were no significant differences between groups. IL-1β increased (2.2-2.5-fold, P < 0.001) during exercise, while TNF-α was increased (1.6-2.0-fold, P < 0.001) during exercise and for 2 h post-exercise. IL-6 (71-84-fold, P < 0.001) and IL-1ra (52-64-fold, P < 0.001) were increased throughout exercise and up to FU1, peaking immediately after exercise and at 1.5-2 h post-exercise, respectively. CK concentrations were increased (P < 0.001) throughout exercise and up to FU4, peaking at FU1, but were not associated with changes in any cytokines. Exhaustive running resulted in modest and transient increases in TNF-α and IL-1β, and more marked and prolonged increases in IL-6 and IL-1ra, but improved training status did not affect this response. Increased CK might indicate either exercise-induced muscle cell disruption or increased cell permeability, although neither appears to have contributed to the increased cytokine concentrations.

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Response to “Unusually low plasma concentrations of lipopolysaccharide following 160-km race”

Cited by 3 publications

References 5 publications

Effect of Exercise Intensity on the Cytokine Response to an Acute Bout of Running

Effect of Exercise Intensity on the Cytokine Response to an Acute Bout of Running

Heat, Athletes, and Immunity

Cytokine response to acute running in recreationally-active and endurance-trained men

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