Response to the reply by C. J. Portier and P. Clausing, concerning our review “Glyphosate toxicity and carcinogenicity: a review of the scientific basis of the European Union assessment and its differences with IARC”

Tarazona, José V.; Court-Marques, Daniele; Tiramani, Manuela; Reich, Hermine; Pfeil, R.; Istace, Fréderique; Crivellente, Federica

doi:10.1007/s00204-017-2032-8

Cited by 14 publications

(5 citation statements)

References 7 publications

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“…The debate over glyphosate even caused the Netherlands to ban non-agricultural uses of glyphosate as of November, 2015, as well as a conflict between the EC and the European Parliament. The scientific background behind the risk assessment by EFSA and BfR was published in a research paper in 2017 (Tarazona et al, 2017a), and was immediately challenged and discussed in the same periodical (Portier et al, 2017;Tarazona et al, 2017b).…”

Section: Registration Of Glyphosate In the European Unionmentioning

confidence: 99%

Re-registration Challenges of Glyphosate in the European Union

Székacs

Darvas

2018

Front. Environ. Sci.

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Section: Registration Of Glyphosate In the European Unionmentioning

confidence: 99%

Re-registration Challenges of Glyphosate in the European Union

Székacs

Darvas

2018

Front. Environ. Sci.

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“…Indeed in 2015, glyphosate was classified as ‘probably carcinogenic for humans’ (Group 2A) by the International Agency for Research on Cancer, whereas the European Food Safety Authority and the European chemical agency concluded that glyphosate is not carcinogenic, mutagen or genotoxic for reproduction. The debate on the safety of glyphosate and glyphosate‐based herbicide in term of carcinogenicity is currently open …”

Section: Introductionmentioning

confidence: 99%

“…The debate on the safety of glyphosate and glyphosate-based herbicide in term of carcinogenicity is currently open. [14][15][16][17] More recently, an increasing number of studies suggest that GBH exposure might affect vertebrate development and physiology. [18][19][20] More precisely, several laboratories found that glyphosate exposure could alter brain physiology and behaviour, independently of its potential carcinogenic and mutagenic properties.…”

mentioning

confidence: 99%

Glyphosate and glyphosate‐based herbicide exposure during the peripartum period affects maternal brain plasticity, maternal behaviour and microbiome

Dechartres

Pawluski

Guéguen

et al. 2019

J Neuroendocrinology

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Glyphosate is found in a large array of non‐selective herbicides such as Roundup® (Monsanto, Creve Coeur, MO, USA) and is by far the most widely used herbicide. Recent work in rodent models suggests that glyphosate‐based herbicides during development can affect neuronal communication and result in altered behaviours, albeit through undefined mechanisms of action. To our knowledge, no study has investigated the effects glyphosate or its formulation in herbicide on maternal behaviour and physiology. In the present study, relatively low doses of glyphosate (5 mg kg‐1 d‐1), Roundup® (5 mg kg‐1 d‐1 glyphosate equivalent), or vehicle were administered by ingestion to Sprague‐Dawley rats from gestational day (GD) 10 to postpartum day (PD)22. The treatments significantly altered licking behaviour toward pups between PD2 and PD6. We also show in the dams at PD22 that Roundup exposure affected the maturation of doublecortin‐immunoreactive new neurones in the dorsal dentate gyrus of the hippocampus of the mother. In addition, the expression of synaptophysin was up‐regulated by glyphosate in the dorsal and ventral dentate gyrus and CA3 regions of the hippocampus, and down‐regulated in the cingulate gyrus. Although a direct effect of glyphosate alone or its formulation on the central nervous system is currently not clear, we show that gut microbiota is significantly altered by the exposure to the pesticides, with significant alteration of the phyla Bacteroidetes and Firmicutes. This is the first study to provide evidence that glyphosate alone or in formulation (Roundup) differentially affects maternal behaviour and modulates neuroplasticity and gut microbiota in the mother.

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“…Residues of glyphosate are detected in human and animal tissues [15,[34][35][36]. Studies have shown that excessive use of glyphosate causes stress to crops and non-target plants and that it is toxic to mammals, microorganisms, and invertebrates [37][38][39]. Some countries have limits on the concentration of glyphosate in drinking water.…”

Section: Properties Applications and Toxicity Of Glyphosatementioning

confidence: 99%

Ion chromatography for the analysis of glyphosate and its selected metabolites. A review

Michalski

Pecyna-Utylska

2023

J of Separation Science

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Among all known compounds with herbicide activity glyphosate, has been the most commercially successful one. Currently, it is under evaluation because of its possible cancerogenic properties. However, the question is-if it is possible to completely withdraw it from use. Before it can happen, it is important to be sure of all its benefits and limitations, and this requires further detailed research. Due to the extent and prevalence of its use, glyphosate ends up in the environment and then in food and our bodies. There are several methods used for their determination. One of them is ion chromatography. Taking into account its advantages and disadvantages, as well as its rapid development, their importance in this field can be expected to increase in the near future. This paper summarizes the literature data from the past 22 years. The applications of ion chromatography in the determination of glyphosate in various types of environmental, food, and other samples are described. Moreover, the methods used so far are compared with the possibilities offered by ion chromatography, which main advantages and benefits are easy availability, low operating costs, green chemistry aspects, and suitable validation parameters.

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Response to the reply by C. J. Portier and P. Clausing, concerning our review “Glyphosate toxicity and carcinogenicity: a review of the scientific basis of the European Union assessment and its differences with IARC”

Cited by 14 publications

References 7 publications

Re-registration Challenges of Glyphosate in the European Union

Re-registration Challenges of Glyphosate in the European Union

Glyphosate and glyphosate‐based herbicide exposure during the peripartum period affects maternal brain plasticity, maternal behaviour and microbiome

Ion chromatography for the analysis of glyphosate and its selected metabolites. A review

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