Cell Reports volume 4, issue 4, P791-802 2013 DOI: 10.1016/j.celrep.2013.07.038 View full text
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Mariana Fregoso Lomas, Fiona Hails, Jean-François Boisclair Lachance, Laura A. Nilson

Abstract: Spatially restricted epidermal growth factor receptor (EGFR) activity plays a central role in patterning the follicular epithelium of the Drosophila ovary. In midoogenesis, localized EGFR activation is achieved by the graded dorsal anterior localization of its ligand, Gurken. Graded EGFR activity determines multiple dorsal anterior fates along the dorsal-ventral axis but cannot explain the sharp posterior limit of this domain. Here, we show that posterior follicle cells express the T-box transcription factors …

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